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| 1 | Polymorphism in the upstream regulatory region of human papilloma virus type 16 from the cervical cancer biopsies in Xinjiang Uygur women显示文摘To investigate the mutations in the upstream regulatory region (URR) of human papillomavirus type 16 (HPV-16) from the cervical cancer biopsies in Xinjiang Uygur women and its relationship to the high incidence of cervical cancer in the southern Xinjiang, the tissue DNA was extracted from the cervical cancer biopsies, and the URR segment of HPV-16 DNA was amplified, sequenced and analyzed. Thereafter, the polymorphism of URR in HPV-16 was then analyzed. It was demonstrated that the positive rate detected for the presence of URR in HPV-16 was 89.47% (17/19). Compared with the previously published sequence in URR of prototype HPV-16, some mutations were detected in the sequence of URR. The mutations in 17 URR fragments of HPV-16 could be divided into 11 patterns (XJU-1 to XJU-11) at nucleic acid level, in which each of XJU-1 and XJU-4 accounted for 23.53% (4/17), and other patterns of mutation accounted for 5.88% (1/17) . In comparison with the URR of prototype HPV-16, the DNA identity of these patterns was 98.50%-99.68% . In these 17 URR fragments, two point mutations occurred at position 7192 (G to T) and position 7520 (G to A) and they appeared to be constant in Xinjiang area. These two mutations were ubiquitous in the Asia-American type and conferred strong infection activity and carcinogenicity of this virus. In addition, the mutations at position 7729 (A to C), position 7843 (A to G) and position 7792 (C to T) could enhance its transcription activity considerably. It is concluded that some mutations occur in URR gene of HPV-16 in the cervical cancer biopsies taken from Uygur women in Xinjiang area, suggesting that certain relationship exists among the mutations in URR of HPV-16, the phylogeny of HPV-16 and the high incidence of cervical cancer in southern part of Xinjiang area. | MENG YU ZHENG HAI MA YAN PIN WANG XI DAN RE FU CHUN ZHANG | 2006 | Journal of Microbiology and Immunology2006，4，3： | 4 |
| 2 | Role of a STAT binding site in the regulation of the human perforin promoter显示文摘 | Yu CR Ortaldo JR Curiel RE | 1999 | J Immunol1999，162，5： | 1 |
| 3 | Host plant simulation of detoxifying enzymes in a phytophagous insect显示文摘 | YU SJ BERRY RE TERRIERE LC | 1979 | Pesticide Biochemistry and Physiology1979，12，： | 1 |
| 4 | Comparative epidemiology of cancers of the colon,rectum,prostate and breast in Shanghai, China versus the United States 显示文摘 | Yu H Harris RE Gao YT | 1991 | Int J Epidemiol1991，20，： | 1 |
| 5 | Salt - as- sisted acid hydrolysis of chitosan to oli- gomers under microwave irradiation 显示文摘 | Xing RE Liu S Yu HH | 2005 | Carbohydrate Research2005，340，13： | 1 |
| 6 | Biliary sterol secretion is notrequired for macrophage reverse cholesterol transport 显示文摘 | Temel RE Sawyer JK Yu L | 2010 | Cell Metab2010，12，1： | 1 |
| 7 | IL-4synergistically enhances both IL-2-and IL-12-induced IFN-γexpression in murine NK cells显示文摘 | Bream JH Curiel RE Yu CR | 2003 | Blood2003，102，： | 1 |
| 8 | Identification of essential amino acid residues in the functional activity of poliovirus 2A protease显示文摘 | Yu SF Lloyd RE | 1991 | Virology1991，182，2： | 1 |
| 9 | Oligodendroglial apoptosiss occurs along degeneration anons and and is associated with FAS and P75 expression following spinal cord inj ury显示文摘 | Casha Re Yu Wr Fehlings MG | 2001 | Neuroscience2001，103，： | 1 |
| 10 | Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors 显示文摘 | Yu YT Breitbart RE Smoot LB | 1992 | Genes Des1992，6，9： | 1 |
| 11 | miR-126 regulates angiogenic signaling and vascular integrity 显示文摘 | Fish JE Santoro MM Morton SU Yu S Yeh RE Wythe JD et ol | 2008 | Dev Cell2008，15，2： | 1 |
| 12 | Transcriptional repression of protein kinase C alpha via Spl by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation 显示文摘 | Zhan M Yu D Liu J Glazer RI Hannay J Pollock RE | 2005 | J Biol Chem2005，280，6： | 1 |
| 13 | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion显示文摘 | Yu L Hammer RE Li-Hawkins J | 2002 | Proc Natl Acad Sci U S A2002，99，16： | 1 |
| 14 | Design and biological evaluation of a series of thiophene-based 3-hydroxy-3-methyl glutaryl coenzyme a reductase inhibitors显示文摘 | COPPOLA GM DAMON RE YU H | 1997 | Bioorg Med Chem Lett1997，7，5： | 1 |
| 15 | Ocular component data in schoolchildren as a function of age and gender显示文摘 | Zadnik K Manny RE Yu JA ct al | 2003 | Optom Vis Sci2003，80，3： | 1 |
| 16 | Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors显示文摘 | Yu YT Breitbart RE Smoot LB | 1992 | Genes Dev1992，6，9： | 1 |
| 17 | Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol显示文摘 | Yu LQ Li-Hawkins J Hammer RE | 2002 | J Clin Inves2002，110，5： | 1 |
| 18 | Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol 显示文摘 | Yu L Li-Hawkins J Hammer RE | 2002 | J Clin Invest2002，110，5： | 1 |
| 19 | Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces frac- tional absorption of dietary cholesterol 显示文摘 | Yu L Li-Hawkins J Hammer RE | 2002 | J Clin Invest2002，110，5： | 1 |
| 20 | Promising therapeutic targets in neuroblastoma显示文摘 | Matthay KK George RE Yu AL | | 0，，10： | 1 |
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