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| 1 | 欧洲呼吸病学会/美国胸科学会官方研究共识:自身免疫特征的间质性肺炎显示文摘在临床工作中,有一类患者被诊断为特发性间质性肺炎(idiopathic interstitial pneumonia,IIP),值得注意的是,实际上这类患者与真正的IIP有所差异,他们除了间质性肺炎的表现外,还具备一些或临床特征、或血清学特征、或影像学特征提示其存在潜在的自身免疫性紊乱,但这些表现又不足以达到某些已知结缔组织病(connective tisslie disease,CTD)的既定诊断标准。 | 宋宁 段林 Fischer A Antoniou KM Brown KK | 2015 | 临床荟萃2015，30，10： | 41 |
| 2 | 加拿大草原地区的残茬覆盖管理显示文摘加拿大草原地区旱地农作史开始于19世纪末期。由于草原干旱、强风条件的影响,以及土壤管理上的失误(如黑色夏休闲等),导致了本世纪30年代特大尘暴的发生,由此引起了40年代农作制的变革──领先推出残茬覆盖农作制,研制出残茬留量高的一类耕作机具,推动厂保持耕作的开展。加拿大半干旱草原50多年保持耕作实践,积累了较多的防止土壤侵蚀的残茬管理经验。 | 王小彬 Klein,KK | 1996 | 土壤肥料1996，，2： | 18 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 5 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 6 | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men显示文摘我们在中国人调查了前列腺特定的抗原(PSA ) 和 PSA 密度(PSAD ) 的表演特征。经历了 transrectal 的所有中国人到 2013 的从 2000 年的指导超声的前列腺活体检视(TRUS-PB ) 被包括。为 PSA 和 PSAD 操作特征(巨鸟) 曲线的接收装置被分析。敏感,特性,积极预兆的价值(PPV ) 和在不同截止层次的否定预兆的价值(NPV ) 是计算的。2606 个中国人的一个总数被包括。为 ROC,在曲线下面的区域为 PSA 是 0.770 (P <0.001 ) 并且 0.823 为 PSAD (P <0.001 ) 。4.5 ng ml −1 的 PSA 94.4% 的有的敏感, 14.1% 的特性, 29.5% 的 PPV,和 86.9% 的 NPV;0.12 ng ml −1 cc −1 的 PSAD 有 94.5% 的敏感, 26.6% 的特性, 32.8% 的 PPV,和 92.7% 的 NPV。在逻辑回归分析的 multivariate 上,在 4.5 ng ml −1 截止的 PSA (或 1.61, 95% CI 1.05-2.45, P = 0.029 ) 并且在 0.12 ng ml −1 cc 截止的 PSAD −1( 或 6.22, 95% CI 4.20-9.22, P <0.001 ) 是为 TRUS-PB 上的前列腺癌症察觉的重要预言者。在结论,在在中国人的不同截止层次的 PSA 和 PSAD 的表演与在白种人的那些很不同。4.5 ng ml −1 的 PSA 和 0.12 ng ml −1 cc −1 的 PSAD 在 95% 敏感附近有并且是在中国人的前列腺癌症察觉的重要预言者。 | Jeremv YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 13 |
| 7 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 8 | Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients:Incidence and risk factors显示文摘AIM: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma(HCC) in Chinese patients with primary biliary cirrhosis(PBC).METHODS: We reviewed the data of 52 PB Cassociated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence and characteristics between the two genders. The risk factors for PBC-associated HCC were analyzed via a case-control study comprising 20 PBC patients with HCC and 77 matched controls without HCC. The matched factors included gender, age, follow-up period and Child-Pugh scores. Conditional logistic regression was used to evaluate the odds ratios of potential risk factors for HCC development. A P < 0.05 was considered statistically significant. RESULTS: The incidence of HCC in Chinese PBC patients was 4.13%(52/1255) and was significantly higher in the males(9.52%) than in the females(3.31%). Among the 52 PBC patients with HCC, 55.76%(29/52) were diagnosed with HCC and PBC simultaneously, and 5.76%(3/52) were diagnosed with HCC before PBC. The males with PBC-associated HCCwere more likely than the females to have undergone blood transfusion(18.75% vs 8.33%, P = 0.043), consumed alcohol(31.25% vs 8.33%, P = 0.010), smoked(31.25% vs 8.33%, P = 0.010), had a family history of malignancy(25% vs 5.56%, P = 0.012), and had serious liver inflammation, as indicated by the elevated levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase(P < 0.05). Conditional logistic regression analysis revealed that body mass index(BMI) ≥ 25 [adjusted odds ratio(AOR) = 1.116, 95%CI: 1.002-1.244, P = 0.045] and history of alcohol intake(AOR = 10.294, 95%CI: 1.108-95.680, P = 0.040) were significantly associated with increased odds of HCC development in PBC patients. CONCLUSION: HCC is not rare in Chinese PBC patients. Risk factors for PBC-associated HCC include BMI ≥ 25 and a history of alcohol intake. In addition to regular monitoring, PBC patients may benefit from abstinence from alcohol and body weight control. | Xue-Xiu Zhang Li-Feng Wang Lei Jin Yuan-Yuan Li Shu-Li Hao Yan-Chao Shi Qing-Lei Zeng Zhi-Wei Li Zheng Zhang George KK Lau Fu-Sheng Wang | 2015 | World Journal of Gastroenterology2015，21，12： | 7 |
| 9 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 10 | 幽门螺杆菌寄居对胃功能及在肝硬化门脉高压性胃病中的发病率的影响显示文摘 | Bala.,KK | 1997 | 国外学者来访报告1997，17，4： | 5 |
| 11 | 近期无机(B,Al,Zn,Mg,Ca和Si)阻燃剂的进展显示文摘 | Shen,KK | 2000 | 阻燃材料与技术2000，，4： | 5 |
| 12 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 13 | 原发性低密度脂蛋白胆固醇≥4.94mmol/L的男性降低低密度脂蛋白胆固醇对心血管病的影响显示文摘原发性低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)≥4.94mmol/L(190mg/dL)的患者由于长期暴露在显著升高的LDL-C下,心血管动脉粥样硬化的风险更高。因此,对于这些患者通常建议采用他汀类药物治疗,但是缺少随机试验证据支持。在该研究中,研究者提供了一些降低LDL-C对心血管病影响的初级预防资料。 | Vallejo-Vaz AJ Robertson M Catapano AL Watts GF Kastelein JJ Packard CJ Ford I Ray KK 黄洁 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 5 |
| 14 | 上颌窦癌的术后放疗显示文摘副鼻窦癌在美国很少见,年发病率约为1/100000。由于发病隐匿,在诊断时往往已到中晚期。而副鼻窦又邻近重要器官,如眼眶、颅底、脑,彻底的肿瘤切除较为困难,满意的放疗设计也受到限制。所以,中晚期副鼻窦癌的治疗十分棘手。本文是回顾性分析,着重研究上颌窦癌的术后放疗。 | 蒋国樑 Ang KK Peters JL wendt CD Oswald MJ Ceopfer TH | 1991 | 中华放射肿瘤学杂志1991，0，3： | 5 |
| 15 | 急性心肌梗死桥血管病变急诊介入治疗的临床研究显示文摘目的评价梗死相关血管为静脉桥血管(SVBG)的急性心肌梗死(AMI)患者,进行急诊直接经皮冠状动脉介入治疗(PCI)的有效性及安全性。方法对≥70岁(213例)与<70岁(96例)两组AMI患者介入治疗的临床效果和不良事件进行比较。分析SVBG有效再通比例、住院期间死亡比例及短期临床预后。结果两组患者PCI的技术成功比例、急性再闭塞比例均未见显著差异。但在≥70岁组,PCI后发生慢血流和无血流现象明显为多、住院期间绝对死亡数为多(20vs4)。死亡病例分析显示,90%的死亡病例出现在发生慢血流无血流现象的病例;多次心肌梗死、SVBG连通优势冠状动脉血管、以及连通惟一剩存的SVBG时,发生无血流慢血流后,死亡危险较高。结论老年AMI患者的SVBG病变急诊介入治疗有明确的效果和高的技术成功率。 | 王禹 Hasse KK 盖鲁粤 杨庭树 沈洪 计达 陈练 孙志军 任艺红 | 2005 | 中华老年心脑血管病杂志2005，7，3： | 4 |
| 16 | Human immune repertoire in hepatitis B virus infection显示文摘Hepatitis B virus(HBV)infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis,liver failure,and hepatocellular carcinoma.The HBV antigen-induced adaptive immune response plays an important role in HBV clearance.Immune repertoire sequencing(IRS)has been used to investigate the molecular mechanisms behind the immune system,find novel ways to treat HBV infection,and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine.This review summarizes the human immune repertoire analysis methodology,and the application of the IRS in the prediction of HBV infection progression,treatment,and vaccination. | Qiao Zhan Jing-Hang Xu Yan-Yan Yu Emily Lo KK Felicianna Hani El-Nezami Zheng Zeng | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 17 | 经直肠超声引导下穿刺活检诊断前列腺癌与直肠指检和前列腺特异性抗原水平的关系:在中国人群中的情况如何?显示文摘我们分析了经直肠超声引导下穿刺活检后前列腺癌的检出率与直肠指检和前列腺特异性抗原水平的关系以及中国人群检出前列腺癌的危险因素。我们从数据库中检索了自2000年到2013年所有首次接受经直肠超声引导下前列腺穿刺活检的中国男性的数据。结合直肠指检的发现以及前列腺特异性抗原水平(〈 4, 4-10, 10.1-20,20.1-50 , 〉 50ng/ml)分析了前列腺癌的检出率。使用多因素Logistic回归研究了前列腺癌检出的潜在危险因素。共有2606中国男性人群纳入该研究。在直肠指检正常的患者中,不同前列腺特异性抗原水平(〈 4, 4-10,10.1-20, 20.1-50, 〉 50 ng/ml)患者前列腺癌的检出率分别为8.6%,13.4%,21.8%,41.7%和85.2%。在直肠指检异常的患者中,不同前列腺特异性抗原水平(〈 4, 4-10, 10.1-20, 20.1-50, 〉 50 ng/ml)患者前列腺癌的检出率分别为12.4%, 30.2%, 52.7%, 80.6%和96.4%。多因素Logistic回归分析提示:老龄、较小的前列腺体积、更多针数的穿刺活检、直肠指检异常发现、较高的PSA水平都与增大的前列腺癌检出风险相关(P 〈0.001)。与西方人群相比,中国男性人群的前列腺癌检出率较低。考虑到不同的危险因素,可以采用个体化的方式来决定是否采取经直肠超声引导下穿刺活检。 | Jeremy YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 18 | 加拿大农业的发展与环境及其持续性显示文摘加拿大农业的历史只有300多年,随着农业技术的进步和生产的发展,环境退化问题如土壤侵蚀、压实、盐渍化、有机质下降、水质污染等已引起了极大的关注。80年代中期直至90年代,农业的重点开始向持续性转移,持续农业是以确保农业生产高产和安全的同时以满足经济、社会以及环境的需求为目标。重点论述了加拿大农业生产中,尤其是半干旱草原地区土壤的环境问题,以及有关的农业持续性发展对策。 | 王小彬 Lein,KK | 1996 | 干旱地区农业研究1996，14，3： | 3 |
| 19 | Eph Receptors and Ephrins in Neuron-Astrocyte Communication at Synapses显示文摘神经元-胶质细胞间的相互作用对调节脑内突触联系有重要作用。星形胶质细胞对突触的发育、维持和可塑性有特别关键、复杂的作用。同样,神经元也对星形胶质细胞的生理功能产生影响。但是,神经元和星形胶质细胞之间相互作用的分子机制尚未完全阐明。近来研究表明,Eph受体酪氨酸激酶及轴突导向因子在突触间接触依赖性神经元-胶质细胞的相互作用中起重要作用。与配体结合后,这2个细胞表面相关蛋白家族成员激活双向信号通路,调节神经元和星形胶质细胞的结构和生理特征。本综述着重探讨Eph受体酪氨酸激酶及轴突导向因子在突触间神经元-胶质细胞的相互作用中扮演的角色,并讨论其在突触可塑性、行为及疾病中的潜在作用。 | Murai KK Pasquale EB | 2011 | 神经损伤与功能重建2011，6，6： | 3 |
| 20 | Impact of enclosure management on soil properties and microbial biomass in a restored semi-arid rangeland, Kenya显示文摘Rangeland degradation is a serious problem throughout sub-Saharan Africa and its restoration is a challenge for the management of arid and semi-arid areas. In Lake Baringo Basin of Kenya, communities and individual farmers are restoring indigenous vegetation inside enclosures in an effort to combat severe land degradation and address their livelihood problems. This study evaluated the impact of enclosure management on soil properties and microbial biomass, being key indicators of soil ecosystem health. Six reseeded communal enclosures using soil embankments as water-harvesting structures and strictly regulated access were selected, varying in age from 13 to 23 years. In six private enclosures, ranging from 3 to 17 years in age, individual farmers emulated the communal enclosure strategy and restored areas for their exclusive use. Significant decreases in bulk density, and increases in the soil organic carbon, total nitrogen and microbial biomass contents and stocks were found in the enclosures as compared with the degraded open rangeland. In the private enclosures, the impact of rehabilitation on the soil quality was variable, and soil quality was in general lower than that obtained under communal management. The significant increase of absolute stocks of carbon, nitrogen and microbial biomass compared to the degraded open rangeland indicates the potential for the restoration of soil quality through range rehabilitation. Over-sowing with indigenous legume fodder species could improve total nitrogen content in the soil and nutritional value of the pastures as well. | Stephen M MUREITHI Ann VERDOODT Charles KK GACHENE Jesse T NJOKA Vivian O WASONGA Stefaan De NEVE Elizabeth MEYERHOFF Eric Van RANST | 2014 | Journal of Arid Land2014，6，5： | 3 |
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