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| 1 | Interacting effects of multiple factors on the morphological evolution of the meandering reaches downstream the Three Gorges Dam显示文摘阐明河的过程上的水坝的影响能通知河保护和盆管理。然而,相对,很少研究集中了多重因素怎么交往影响蜿蜒地流的活动范围的词法进化。用水文学和地形学的数据,我们分析了下游地影响并且调整蜿蜒地流的活动范围的因素三个峡水坝(TGD ) 。我们的结论如下。(1 ) 蜿蜒地流的活动范围能在预先建水坝时期期间基于他们的进化被分类进二种类型:G1 活动范围,由侵蚀和凹面隧道免职(CECD ) ,和 G2 到达的凸的点酒吧描绘了,由凸的点酒吧免职和凹面隧道侵蚀(CDCE ) 描绘了。两种活动范围类型在水坝以后的时期期间展出了 CECD 特征。(2 ) 流动过程和沉积运输是引起了位于凸的点酒吧的低沙滩的严肃的侵蚀的因素。然而,在河政体,河边界和东廷·莱克的 jacking 的变化不对蜿蜒地流的活动范围的词法进化作为主要控制起作用。(3 ) 充满在凸的点酒吧的更大的侵蚀从 20,000 ~ 25,000 m 3/s 结果的分泌物。如果这些流动的持续时间,接近满满的分泌物,超过 20 天,点酒吧变得搜索。另外,在水流带来的碎石的减小引起在 water-falling 时期点酒吧 siltation 减少。(4 ) 在水坝以后的经期,洪水消退,分泌物从 20,000 ~ 25,000 m 3/s,的增加的持续时间和在沉积的重要减小期间,运输是引起了蜿蜒地流的活动范围显示出 CECD 特征的主要因素。在他们能通知估计河床变化,河管理策略和河保护的地方,我们的结果与另外的蜿蜒地流的活动范围相关。 | HAN Jianqiao ZHANG Wei FAN Yongyang YU Mengqing | 2017 | Journal of Geographical Sciences2017，27，10： | 3 |
| 2 | Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner显示文摘Although neoantigen-based cancer vaccines show great potential in cancer immunotherapy due to their ability to induce effective and long-lasting anti-tumor immunity,their development is hindered by the limitations of neoantigens identification,low immunogenicity,and weak immune response.Cyclophosphamide(CTX)not only directly kills tumors but also causes immunogenic cell death,providing a promising source of antigens for cancer vaccines.Herein,a combined immunotherapy strategy based on temperature-sensitive PLEL hydrogel is designed.First,CTX-loaded hydrogel is injected intratumorally into CT26 bearing mice to prime anti-tumor immunity,and then 3 days later,PLEL hydrogels loaded with CpG and tumor lysates are subcutaneously injected into both groins to further promote anti-tumor immune responses.The results confirm that this combined strategy reduces the toxicity of CTX,and produces the cytotoxic T lymphocyte response to effectively inhibit tumor growth,prolong survival,and significantly improve the tumor cure rate.Moreover,a long-lasting immune memory response is observed in the mice.About 90%of the cured mice survive for at least 60 days after being re-inoculated with tumors,and the distant tumor growth is also well inhibited.Hence,this PLEL-based combination therapy may provide a promising reference for the clinical promotion of chemotherapy combined with cancer vaccines. | Fan Yang Kun Shi Ying Hao Yanpeng Jia Qingya Liu Yu Chen Meng Pan Liping Yuan Yongyang Yu Zhiyong Qian | 2021 | Bioactive Materials2021，6，10： | 2 |
| 3 | Hydrogen -rich saline resusci- tation alleviates inflammation induced by severe burn with delayed resuscitation显示文摘 | Wang X Yu P YongYang | 2015 | Bums2015，41，2： | 1 |
| 4 | A new hybrid DCT-wiener based interpolation scheme for video intra frame up-sampling 显示文摘 | Wu Zhenyu Yu Yongyang CHEN Changwen | 2010 | IEEE Signal Pro- cessing Letters2010，17，10： | 1 |
| 5 | Patterns of neoplastic foci and lymph node micrometastasis within the mesorectum显示文摘 | Cun Wang Zongguang Zhou Zhao Wang Yangchun Zheng Gaoping Zhao Yongyang Yu Zhong Cheng Daiyun Chen Weiping Liu | 2005 | Langenbeck’s Archives of Surgery2005，，4： | 1 |
| 6 | Sustained co-delivery of 5-fluorouracil and cis-platinum via biodegradable thermo-sensitive hydrogel for intraoperative synergistic combination chemotherapy of gastric cancer显示文摘Gastric cancer is the fifth most common cancer and the third leading cause of cancer death worldwide,posing a severe threat to human health.Surgical resection remains the most preferred option for gastric cancer treatment.However,for advanced gastric cancer,the curative effect of surgical resection is usually limited by the local recurrence,peritoneal carcinomatosis,or distal metastasis.Intraoperative chemotherapy is an attractive in situ adjuvant treatment strategy to reduce the recurrence and metastasis after surgical resection.Here,we designed a 5-fluorouracil(5-FU)and cis-platinum(DDP)co-delivery system based on a biodegradable temperature-sensitive hydrogel(PDLLA-PEG-PDLLA,PLEL)for intraoperative adjuvant combination chemotherapy of gastric cancer.This 5-FU+DDP/PLEL hydrogel system characterized by a special sol-gel phase transition in response to physiological temperature and presented sustained drug release in vitro and in vivo.A strong synergistic cell proliferation inhibition and apoptosis promotion of 5-FU+DDP/PLEL were observed against gastric cancer MKN45-luc cells.After intraperitoneal injection,the dual-drug loaded hydrogel formulation showed superior anti-tumor effects than the single-drug carrying hydrogels and combination of free 5-FU and DDP on the gastric cancer peritoneal carcinomatosis model.The use of hydrogel for dual-drug delivery had benefited to fewer side effects as well.What’s more,we established a mouse model for postsurgical residual tumors and peritoneal carcinomatosis of gastric cancer,in which the intraoperative administration of 5-FU+DDP/PLEL also remarkably inhibited the local recurrence of the orthotopic tumors and the growth of the abdominal metastatic tumors,resulting in an extended lifetime.Hence,this developed dual-drug loaded hydrogel system has great potential in the intraoperative chemotherapy of gastric cancer,that suggests a clinically-relevant and valuable option for postsurgical management of gastric cancer. | Wen Chen Kun Shi Jie Liu Peipei Yang Ruxia Han Meng Pan Liping Yuan Chao Fang Yongyang Yu Zhiyong Qian | 2023 | Bioactive Materials2023，，5： | 0 |
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