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| 1 | Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells显示文摘 | Yucui Dong Qinglian Han Yan Zou Zhenling Deng Xinliang Lu Xiaohua Wang Weihua Zhang Hua Jin Jun Su Tao Jiang Huan Ren | 2012 | Molecular and Cellular Biochemistry2012，，1： | 2 |
| 2 | High-throughput“read-on-ski”automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids显示文摘Organoid models are used to study kidney physiology,such as the assessment of nephrotoxicity and underlying disease processes.Personalized human pluripotent stem cell-derived kidney organoids are ideal models for compound toxicity studies,but there is a need to accelerate basic and translational research in the field.Here,we developed an automated continuous imaging setup with the“read-on-ski”law of control to maximize temporal resolution with minimum culture plate vibration.High-accuracy performance was achieved:organoid screening and imaging were performed at a spatial resolution of 1.1µm for the entire multi-well plate under 3 min.We used the in-house developed multi-well spinning device and cisplatin-induced nephrotoxicity model to evaluate the toxicity in kidney organoids using this system.The acquired images were processed via machine learning-based classification and segmentation algorithms,and the toxicity in kidney organoids was determined with 95%accuracy.The results obtained by the automated“read-on-ski”imaging device,combined with label-free and non-invasive algorithms for detection,were verified using conventional biological procedures.Taking advantage of the close-to-in vivo-kidney organoid model,this new development opens the door for further application of scaled-up screening using organoids in basic research and drug discovery. | Qizheng WANG Jun LU Ke FAN Yiwei XU Yucui XIONG Zhiyong SUN Man ZHAI Zhizhong ZHANG Sheng ZHANG Yan SONG Jianzhong LUO Mingliang YOU Meijin GUO Xiao ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，7： | 0 |
| 3 | Application of Rubidium in the Field of Medicine and Health显示文摘With the continuous development of science and technology,the role of rare and precious metal resources in medical treatment,economy and strategy has become increasingly prominent.This paper reviewed the application research of rare precious metal rubidium(Rb)in the field of medicine and health,mainly including the application significance of Rb in the field of medical and health,typical applications and problems in the field of medicine and health,and the important research significance of the research and development of medicine. | Lichun ZHAO Yucui LU Wenbin ZHANG Shilei DING Xiayun LIAO Jiaping PAN | 2021 | Agricultural Biotechnology2021，10，4： | 0 |
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