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| 1 | Expenditure of hospital care on cancer in China, from 2011 to 2015显示文摘Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention.However, studies on economic burden of cancers in China are scant and the results are inconsistent.Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals.Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments(67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China.Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisioning, prevention strategies, research funding, and assessing whether the economic burden of cancer is affordable to the governments. | Yue Cai Ming Xue Wanqing Chen Maogui Hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，3： | 81 |
| 2 | Immunohistochemical study on p53,H-rasp21,c-erbB-2 protein and PCNA expression in HCC tissues of Hart and minority ethnic patients显示文摘AIM To find out the difference of humanprimary liver carcinogenesis between Han andminority ethnic patients in Xinjiang.METHODS Expression of p53,c-erbB-2,H-rasp21 protein and proliferating cell nuclearantigen(PCNA)in tumor tissues of 50 patients(Han 38,minority 12)with primary hepaticcarcinoma was detected byimmunohistochemistry(LSAB).RESULTS The positive frequency of p53,c-erbB-2,H-rasp21 and PCNA expression was46.0%(23/50),70.0%(35/50),68.0%(34/50)and 82.0%(41/50)in tumor tissues;4.0%(2/50),22.0%(11/50),64.0%(32/50)and 52.0%(26/ 50)in peritumors respectively and asignificant difference,except for H-rasp21,ofoncogene alteration was found(P<0.05)between tumor and non-tumorous tissues.Combined the three oncogenes alteration,26%(13/50)tumor tissues had positiveimmunoreactivity,but in peritumor and normallivers it was negative.The positive rate of p53,c-erbB-2 and H-rasp21 protein expression was39.5%(15/38),60.5%(23/38)and 39.5%(15/38)in tumors of Han patients;66.7%(8/12),100%(12/12)and 75.0%(9/12)in minoritiesrespectively,with statistical difference (P<0.05).CONCLUSION Overexpression of p53,c-erbB-2and H-rasp21 in human primary liver carcinoma isan important biomarker of genetic alteration.The different frequency of these oncogeneticchanges may reflect some environmental or/andethnic hereditary factors affecting the livercarcinogenesis.The special life style of Han,Uygur,Kazak and Mongolia nationalities inXinjiang may also be related to theetiopathogenesis of this disease. | Guo Yue Lin Zhao Lun Chen Cai Mo Lu Ying Li Xiao Jia Ping Rong Huang Department of Laboratory Medicine,Chinese PLA 474 Hospital,Urumqi 830011,Xinjiang Uygur Autonomic Region,China Department of Pathology,the 1st Teaching Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomic Region,China | 2000 | World Journal of Gastroenterology2000，6，2： | 40 |
| 3 | Colorectal cancer lymph node staining by activated carbon nanoparticles suspension in vivo or methylene blue in vitro显示文摘AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patients treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012.Seven patients refused to participate.Eventually,60 patients were included,and randomly assigned to three groups(20 in each group):ACNS group(group A),MB group(group B) and non-stained conventional surgical group(group C).In group A,patients received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass.In group B,the main artery of specimen was identified and isolated after the specimen was removed,and 2 mL MB was slowly injected into the isolated,stretched and fixed vessel.In group C,no ACNS and MB were injected.All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue.RESULTS:No difference was observed among the three groups in age,gender,tumor location,tumor diameter,T-stage,degree of differentiation,postoperative complications and peritoneal drainage retention time.The total number of detected lymph nodes was 535,476 and 223 in the three groups,respectively.The mean number of detected lymph nodes per patient was significantly higher in group A than in group C(26.8 ± 8.4 vs 12.2 ± 3.2,P < 0.001).Similarly,there were significantly more lymph nodes detected in group B than in group C(23.8 ± 6.9 vs 12.2 ± 3.2,P < 0.001).However,there was no significant difference between group A and group B.There were 50,46 and 32 metastatic lymph nodes dissected in 13 patients of group A,10 patients of group B and 11 patients of group C,without significant differences among the three groups.Eleven of the 60 patients had insufficient number of detected lymph nodes(< 12).Only one patient with T 4a rectal cancer had 10 lymph nodes detected in group B,the other 10 patients were all from group C.Based on the different diameter categories,the number of detected lymph nodes in groups A and B was significantly higher than in group C.However,there was no statistically significant difference between group A and group B.The metastatic lymph nodes were not significant different among the three groups.Similarly,tumor location,T stage and tumor differentiation did not affect the staining results.Body mass index was a minor influencing factor in the two different staining methods.The stained lymph nodes can easily be identified from the mesenteric adipose tissues,and the staining time for lymph nodes was not significantly different compared with unstained group.None of the patients in groups A and B had drug-related complications.CONCLUSION:Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer. | Hong-Ke Cai Hai-Fei He Wei Tian Mei-Qi Zhou Yue Hu Yong-Chuan Deng | 2012 | World Journal of Gastroenterology2012，18，42： | 39 |
| 4 | Constraining the stepwise migration of the eastern Tibetan Plateau margin by apatite fission track thermochronology显示文摘Granites sampled from Garzê-Litang thrust, Longmen Shan thrust, Garzê and Litang strike-slip faults in the eastern Tibetan Plateau have been analyzed with apatite fission track thermochronological method in this study. The measured fission track apparent ages, combined with the simulated annealing mod- eling of the thermal history, have been used to reconstruct the thermal evolutionary histories of the samples and interpret the active history of the thrusts and faults in these areas. Thermal history mod- eling shows that earlier tectonic cooling occurred in the Garzê-Litang thrust in Miocene (~20―16 Ma) whereas the later cooling occurred mainly in the Longmen Shan thrust since ~5 Ma. Our study sug- gests that the margin of eastern Tibetan Plateau was extended by stages: through strike-slip faults deformations and related thrusts, the upper crust formed the Garzê-Litang margin in the Miocene epoch and then moved to the Longmen Shan margin since ~5 Ma. During this process, the deformations of different phases in the eastern Tibetan Plateau were absorbed by the thrusts within them and conse- quently the tectonic events of long-distance slip and extrusion up to hundreds of kilometers have not been found. | LAI QingZhou DING Lin WANG HongWei YUE YaHui CAI FuLong | 2007 | Science China Earth Sciences2007，50，2： | 24 |
| 5 | Genome-wide analysis of the WRKY transcription factor gene family in Gossypium raimondii and the expression of orthologs in cultivated tetraploid cotton显示文摘WRKY proteins are members of a family of transcription factors in higher plants that function in plant responses to various physiological processes.We identified 120 candidate WRKY genes from Gossypium raimondii with corresponding expressed sequence tags in at least one of four cotton species,Gossypium hirsutum,Gossypium barbadense,Gossypium arboreum,and G.raimondii.These WRKY members were anchored on 13 chromosomes in G.raimondii with uneven distribution.Phylogenetic analysis showed that WRKY candidate genes can be classified into three groups,with 20 members in group I,88 in group II,and 12 in group III.The88 genes in group II were further classified into five subgroups,groups IIa–e,containing 7,16,37,15,and 13 members,respectively.We characterized diversity in amino acid residues in the WRKY domain and/or other zinc finger motif regions in the WRKY proteins.The expression patterns of WRKY genes revealed their important roles in diverse functions in cotton developmental stages of vegetative and reproductive growth and stress response.Structural and expression analyses show that WRKY proteins are a class of important regulators of growth and development and play key roles in response to stresses in cotton. | Caiping Cai Erli Niu Hao Du Liang Zhao Yue Feng Wangzhen Guo | 2014 | The Crop Journal2014，2，Z1： | 23 |
| 6 | Relationship between tumor necrosis factor-α and liver fibrosis显示文摘RelationshipbetweentumornecrosisfactorαandliverfibrosisWANGXin,CHENYueXiang,XUCaiFu,ZHAOGuoNing,HUANGYuXinandWANGQinLiD... | WANG Xin, CHEN Yue Xiang, XU Cai Fu, ZHAO Guo Ning, HUANG Yu Xin and WANG Qin Li Department of Gastroenterology, Tangdu Hospital, The Fourth Military Medical University, Xi′an 710038, Shaanxi Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 7 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 8 | TGF-β1 gene-modified,immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4^(+)Foxp3^(+)regulatory T cells显示文摘Inflammatory bowel disease(IBD)is caused by an uncontrolled immune response in the intestinal lumen,leading to inflammation in genetically predisposed individuals.Immunotherapy may be a promising approach to the treatment of IBD.Here,we show that transforming growth factor-β1(TGF-β1)gene-modified immature dendritic cells(imDCs)could enhance the inhibitory function of imDCs and delay the progress of IBD induced by dextran sodium sulfate in mice.The results of fluorescence-activated cell sorter(FACS)demonstrated that this protective effect is mediated partially by inducing CD4^(+)Foxp3^(+)regulatory T cells(Tregs)in mesentery lymph nodes to control inflammation.In vitro experiments also supported this hypothesis.In conclusion,we provide evidence that TGF-b1-modified bone marrow-derived imDCs may have a therapeutic effect to IBD. | Zhijian Cai Wei Zhang Min Li Yinpu Yue Fei Yang Lei Yu Xuetao Cao Jianli Wang | 2010 | Cellular & Molecular Immunology2010，7，1： | 18 |
| 9 | Current understanding of coronary artery calcification显示文摘冠的动脉石灰化(CAC ) 在有冠的心疾病(CHD ) 的病人是高度流行的并且与主要不利心血管的事件被联系。有 CAC— 的二种公认的类型;他们的内层、中间的石灰化,和各个有特定的风险因素。关于脉管的石灰化的机制的几个理论被提出了,并且我们当前相信脉管的石灰化是一个活跃、调整过程。CAC 能通常与严重 CHD,和这无征状的现象在病人被发现使 CAC 的早诊断重要。冠的计算 tomographic angiography 是主要 noninvasive 工具检测钙化的损害。由得分的冠的动脉石灰化的测量是为在在中间的风险的无征状的成年人的心血管的风险评价的一个合理度量标准。迄今为止, CAC 的有效医疗没被识别。经皮的冠的干预的几策略与 CAC,但是与不能令人满意的结果被用于 CHD 病人。CAC 的预后仍然是 CHD 病人的一个主要问题。因此,关于 CAC 的机制的更多的细节需要被阐明以便改进 CAC 的理解和治疗。 | Wei LIU Yue ZHANG Cheuk-Man YU Qing-Wei JI Meng CAI Ying-Xin ZHAO Yu-Jie ZHOU | 2015 | Journal of Geriatric Cardiology2015，12，6： | 15 |
| 10 | Clinical efficacy and safety of selective trans-cystic intra-operative cholangiography in primary suture following three-port laparoscopic common bile duct exploration显示文摘 | SUN Dong-lin ZHANG Feng CHEN Xue-min JIANG Hong-yuan YANG Chun SUN Ya-ping YANG Bo YANG Yue CAI Hui-hua WANG Cao-ye WU Xin-quan | 2012 | Chinese Medical Journal2012，，19： | 14 |
| 11 | Lie Bialgebras of Generalized Virasoro-like Type显示文摘In this paper,Lie bialgebra structures on generalized Virasoro-like algebras are studied.Itis proved that all such Lie bialgebras are triangular coboundary. | Yue Zhu WU Guang Ai SONG Yu Cai SU | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 13 |
| 12 | Comparisons of multiple characteristics between young and old lung cancer patients显示文摘 | JIANG Wei KANG Yue SHI Guang-yue ZHANG Hai-yu CAI Li SUN Xiu-wei SUN Li-chun SUI Guang-jie | 2012 | Chinese Medical Journal2012，，1： | 13 |
| 13 | The functional analysis of OsTDF1 reveals a conserved genetic pathway for tapetal development between rice and Arabidopsis显示文摘在花药开发期间, tapetum 为花粉开发提供材料和营养素。在 Arabidopsis,几个抄写因素被识别了为 tapetal 开发和功能形成一条基因小径(DYT1TDF1AMSMS188MS1 ) 。在 TAPETAL 开发和 FUNCTION1 (TDF1 ) 的有缺陷者是 R2R3 MYB 家庭的一个成员并且为在 Arabidopsis 的早 tapetum 开发是必要的。这里,我们在米饭描绘了 Arabidopsis TDF1 的 ortholog, OsTDF1 (LOC_Os03g18480 ) 。OsTDF1 分享 69 ? 有在 N 终端区域附近的通常认为的 MYB 领域的 AtTDF1 的 % 氨基酸顺序身份。RT-PCR 并且在 situ 杂交表演,那 OsTDF1 明确地在米饭花药的 tapetal 房间被表示。在 Arabidopsis tdf1 异种的 OsTDF1 的表达式恢复它的富饶,建议这个相当或相同的事物能完成在 Arabidopsis 的 TDF1 的正常函数。ostdf1 大美人异种展出男性无菌的显型。它的 tapetal 房间展出类似于 Arabidopsis tdf1 异种的 vacuolated 和 hypertrophic 显型。终端 deoxynucleotidyl 当为 tapetum 的一个必要管理者规划了房间死亡,把试金标记的调停 transferase 的 dUTP 刻痕结束揭示了 OsTDF1 行为。qRT-PCR 分析表明 OsTDF1 UDT1 下游地行动,建议为 tapetum 开发的基因小径通常在米饭和 Arabidopsis 之间被保存并且在米饭的 TDR, EAT1, OsMYB103 和 PTC1 在上游。 | Ci-Feng Cai Jun Zhu Yue Lou Zong-Li Guo Shuang-Xi Xiong Ke Wang Zhong-Nan Yang | 2015 | Science Bulletin2015，60，12： | 13 |
| 14 | Application and reliability analysis of DPM system in site investigation of HK weathered granite显示文摘A drilling process monitor (DPM) for ground characterization of weathered granite is presented. The monitor is portable and can be mounted on a hydraulic rotary drilling rig to record various drilling parameters in real time during normal subsurface in- vestigation. The identification method for dominative and subsidiary interfaces has been established. The study reveals that the monitored drilling parameters are dependent on geotechnical materials and can be further applied to characterize ground interfaces. The t-test between manual logging and DPM logging has been carried out. The results show that the DPM has high accuracy in inter- faces detection and well agreement with the manual logging. The findings show that the device and data analysis method are of po- tential application in subsurface drilling exploration in weathered granites. It also seems to have prospective uses in the determination of orebody boundary as well as in the detection of geohazards. | Zhuoying Tan Meifeng Cai Zhongqi Yue L.G. Tham C.F. Lee | 2005 | Journal of University of Science and Technology Beijing2005，12，6： | 12 |
| 15 | 2019 Chinese guideline for the management of hypertension in the elderly显示文摘Table of contents Preamble 1 Introduction 1.1 Class of recommendations and level of evidences 1.2 Definition and categories of hypertension in the elderly 1.3 Current status of epidemiology of hypertension in the elderly 1.4 The characteristics of hypertension in the elderly. | 无 Qi HUA Li FAN Jun CAI Lu-Yuan CHEN Wei-Wei CHEN Ping-Jin GAO Yi-Fang GUO Qing HE Jing LI Nan-Fang LI Wei-Min LI Yue LI Mei-Lin LIU Ning-Ling SUN Wen WANG Liang-Di XIE Jin-Gang YANG Hong YUAN | 2019 | Journal of Geriatric Cardiology2019，16，2： | 11 |
| 16 | Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective显示文摘Non-small cell lung cancer is a prevalent and rapidly-expanding challenge to modern medicine. While generalized medicine with traditional chemotherapy yielded comparatively poor response rates and treatment results, the cornerstone of personalized medicine using genetic profiling to direct treatment has exalted the successes seen in the field and raised the standard for patient treatment in lung and other cancers. Here, we discuss the current state and advances in the field of personalized medicine for lung cancer, reviewing several of the mutation-targeting strategies that are approved for clinical use and how they are guided by patient genetic information. These classes include inhibitors of tyrosine kinase(TKI), anaplastic lymphoma kinase(ALK), and monoclonal antibodies. Selecting from these treatment plans and determining the optimal dosage requires in-depth genetic guidance with consideration towards not only the underlying target genes but also other factors such as individual metabolic capability and presence of resistance-conferring mutations both directly on the target gene and along its cascade(s).Finally, we provide our viewpoints on the future of personalized medicine in lung cancer, including target-based drug combination, mutation-guided drug design and the necessity for data of population genetics, to provide rough guidance on treating patients who are unable to get genetic testing. | Wenxiao Jiang Guiqing Cai Peter C.Hu Yue Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 10 |
| 17 | DNA barcoding of 18 species of Bovidae显示文摘Genetic divergences of mitochondrial cytochrome c oxidase subunit I genes,known as DNA barcodes,have been used in species identification in the animal kingdom.Barcodes can assist field workers and taxonomists to determine groups in need of taxa analysis,and facilitate the recognition of appropriate populations and scales for conservation planning.In this study,18 species of Bovidae were selected to evaluate the effectiveness of DNA barcoding for species differentiation.The results showed that all but 2 species had unique DNA barcodes.The mean intraspecific variation was 0.63%,yielding a threshold of 6.3% for flagging putative species.The results supported the inference that barcode variation within species of mammals is somewhat higher than within other animal groups.The present study validated the effectiveness of barcoding for the identification of bovid species. | CAI YanSen ZHANG Liang SHEN FuJun ZHANG WenPing HOU Rong YUE BiSong LI Jing ZHANG ZhiHe | 2011 | Chinese Science Bulletin2011，56，2： | 10 |
| 18 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 19 | Analysis of inpatient payments of breast cancer patients with different medical insurance coverages in China(mainland) in 2011–2015显示文摘Objective: An understanding of the levels and trends of medical cost is made for breast cancer patients with different medical insurance coverages in China(mainland), in an attempt to offer a clue to further control the costs.Methods: The inpatient payments of 9,716,180 breast cancer patients spent in medical institutions of different types and grades during 2011–2015 were collected from the inpatient medical record home page(IMRHP) dataset.The data were then processed with SAS(Version 9.3; SAS Institute, Cary, NC, USA). Indicators like means,increase(decrease) percentages were used to descriptively analyze the average hospitalization expense of each time(AHEET) and its trends of breast cancer patients with different medical insurance coverages treated in medical institutions of different types and grades.Results:In 2011–2015,the AHEET borne by breast cancer patients in China had been constantly increasing.Specifically,the self-pay inpatients had the largest increase,inpatients covered by Urban Employee Basic Medical Insurance(UEBMI)and Urban Resident Basic Medical Insurance(URBMI)were the next,and those covered by New Rural Cooperative Medical System(NRCMS)had the least increase.Breast cancer inpatient treated in public hospitals had quite greater increase and higher expenditure level than those in private hospitals.The AHEET borne by the inpatients in Grade 3 hospitals had greater increase and higher cost than those in Grade 2 hospitals.Conclusions:The inpatient payments of breast cancer patients will be wisely controlled by reducing the number of self-pay inpatients,taking advantage of restriction mechanism of the medical insurances,and promoting healthy competition between private hospitals and public hospitals.The economic burden imposed on the society by breast cancer can be relieved through further control of inpatient payments of UEBMI-and URBMI-covered breast cancer patients and of Grade 3 hospitals. | Rui Li Liang Zhang Jinxia Yang Yue Cai Wanqing Chen Lan Lan Ming Xue Qun Meng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 9 |
| 20 | Radiofrequency Ablation versus Liver Resection for Colorectal Cancer Liver Metastasis: An Updated Systematic Review and Meta-analysis显示文摘 | Yue Han Dong Yan Fei Xu Xiao Li Jian-Qiang Cai | 2016 | Chinese Medical Journal2016，，24： | 9 |
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