|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 2 | Mapping the vegetation distribution of the permafrost zone on the Qinghai-Tibet Plateau显示文摘In this paper,an updated vegetation map of the permafrost zone in the Qinghai-Tibet Plateau(QTP) was delineated.The vegetation map model was extracted from vegetation sampling with remote sensing(RS) datasets by decision tree method.The spatial resolution of the map is 1 km×1 km,and in it the alpine swamp meadow is firstly distinguished in the high-altitude areas.The results showed that the total vegetated area in the permafrost zone of the QTP is 1,201,751 km^2.In the vegetated region,50,260 km^2 is the areas of alpine swamp meadow,583,909 km^2 for alpine meadow,332,754 km^2 for alpine steppe,and 234,828 km^2 for alpine desert.This updated vegetation map in permafrost zone of QTP could provide more details about the distribution of alpine vegetation types for studying the vegetation mechanisms in the land surface processes of highaltitude areas. | WANG Zhi-wei WANG Qian ZHAO Lin WU Xiao-dong YUE Guang-yang ZOU De-fu NAN Zhuo-tong LIU Guang-yue PANG Qiang-qiang FANG Hong-bing WU Tong-hua SHI Jian-zong JIAO Ke-qin ZHAO Yong-hua ZHANG Le-le | 2016 | Journal of Mountain Science2016，13，6： | 26 |
| 3 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 4 | Comparative analysis of twenty-five compounds in different parts of Astragalus membranaceus var.mongholicus and Astragalus membranaceus by UPLC-MS/MS显示文摘As a traditional Chinese medicine,the root of Astragalus membranaceus var.mongholicus(AMM)or A.membranaceus(AM)has been widely used in China and other Asian countries for thousands of years.Till now,the flavonoids,phenolic acids and saponins are considered as the main active components contributing to their therapeutic effect in these plants.In order to clarify the distribution and contents of these compounds in different organs of these plants,a rapid and sensitive analytical method for simultaneous determination of 25 active compounds including seven types(i.e.dihydroflavones,isoflavane,isoflavones,flavones,pterocarpans,phenolic acid and saponins)within 10 min was established using ultra-pressure liquid chromatography coupled with tandem mass spectrometry(UPLCeMS/MS).Then,the established method was fully validated and successfully applied to the determination of the contents of these analytes in different parts(root,rhizome,stem,leaf and flower)of AMM and AM.The results indicated that the contents of the same type of compounds in two different species plants were significantly different.Moreover,the obvious differences were also found for the distribution and contents of different type of compounds in five organs of the same species.The present study could provide necessary information for the rational development and utilization of AMM and AM resource. | Yuan Li Sheng Guo Yue Zhu Hui Yan Da-Wei Qian Han-Qing Wang Jian-Qiang Yu Jin-Ao Duan | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 23 |
| 5 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 6 | Performance of dithiocarbamate-type flocculant in treating simulated polymer flooding produced water显示文摘Produced water from polymer flooding is difficult to treat due to its high polymer concentration,high viscosity,and emulsified characteristics.The dithiocarbamate flocculant,DTC (T403),was prepared by the amine-terminated polyoxypropane-ether compound known as Jeffamine-T403.The product was characterized by IR spectra and elemental analysis.The DTC agent chelating with Fe 2+ produced a network polymer matrix,which captured and removed oil droplets efficiently.Oil removal by the flocculent on simulated produced water with 0,200,500,900 mg/L of partially hydrolyzed polyacrylamide (HPAM) was investigated for aspects of effectiveness of DTC (T403) dosage and concentrations of HPAM and Fe 2+ ions in the wastewater.Results showed that HPAM had a negative influence on oil removal efficiency when DTC (T403) dosage was lower than 20 mg/L.However,residual oil concentrations in tested samples with different concentrations of HPAM all decreased below 10 mg/L when DTC (T403) dosage reached 30 mg/L.The concentration of Fe 2+ in the initial wastewater had a slight effect on oil removal at the range of 2-12 mg/L.Results showed that Fe 3+ could not be used in place of Fe 2+ as Fe 3+ could not react with DTC under flocculated conditions.The effects of mineral salts ions were also investigated. | Baoyu Gao | 2011 | Journal of Environmental Sciences2011，23，1： | 18 |
| 7 | The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro显示文摘多重骨髓瘤(公里) 被恶意的血浆房间和倔强的同种细胞的增长描绘到传统的治疗。exosomes 涉及 modulating,这被显示出前进和通过 microRNAs (米尔) 的癌症的转移。Ceramide 是 sphingolipid 的一种类型;exosomal 分泌物的 ceramide 小径被显示了影响癌症房间的 apoptosis。但是在公里房间功能, exosome 功能和米尔规定的这条小径的角色仍然保持未知。在这研究,我们显示出那 C6 ceramide (外长的 ceramide 补充, 1.25-40 mol/L ) dose-dependently 禁止了增长并且在人的公里 OPM2 房间线支持了 apoptosis,它与提高的 caspase 3/9 和 PARP 劈开被联系。我们也发现 C6 ceramide (5-20 mol/L ) dose-dependently 刺激了 exosome 分泌物并且增加了肿瘤镇压的米尔的 exosomal 层次(米尔 202,米尔 16,米尔 29b 和米尔 15a ) 。笔记,从 C6 对待 ceramide 的 OPM2 房间的 exosomes 能影响接受者 OPM2 房间的增长和 apoptosis,它与增加的肿瘤镇压的 exosomal 米尔相关。相反, GW4869 (一个 ceramide 禁止者, 5-20 mol/L ) 在公里 exosomes 在公里功能, exosome 分泌物和米尔层次的规定上施加了相反的效果。然而,从对待 GW4869 的 OPM2 房间的 exosomes 没在这些米尔和指向的 OPM2 房间的幸存上有效果。一起拿,我们的调查结果表明 ceramide 小径调制公里幸存,可能直接经由 caspase 小径并且间接地经由 exosomal 米尔机制。 | Qian CHENG Xin LI Yue WANG Min DONG Feng-huang ZHAN Jing LIU | 2018 | Acta Pharmacologica Sinica2018，39，4： | 15 |
| 8 | Preoperative Corticosteroid Usage and Hypoalbuminemia Increase Occurrence of Short-term Postoperative Complications in Chinese Patients with Ulcerative Colitis显示文摘 | Ji Li Hong Lyu Hong Yang Yue Li Bei Tan Ming-Ming Wei Xi-Yu Sun Jing-Nan Li Bin Wu Jia-Ming Qian | 2016 | Chinese Medical Journal2016，，4： | 14 |
| 9 | Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive.Here we demonstrated that the SGLT2 inhibitor,Empagliflozin(EMPA),suppresses cardiomyocytes autosis(autophagic cell death)to confer cardioprotective effects.Using myocardial infarction(Ml)mouse models with and without diabetes mellitus,EMPA treatment significantly reduced infarct size,and myocardial fibrosis,thereby leading to improved cardiac function and survival.In the context of ischemia and nutritional glucose deprivation where autosis is already highly stimulated,EMPA directly inhibits the activity of the Na^(+)/H^(+)exchanger 1(NHE1)in the cardiomyocytes to regulate excessive autophagy.Knockdown of NHE1 significantly rescued glucose deprivation-induced autosis.In contrast,overexpression of NHE1 aggravated the cardiomyocytes death in response to starvation,which was effectively rescued by EMPA treatment.Furthermore,in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA s cardioprotective effects are at least in part through downregulation of autophagic flux.These findings provide new insights for drug development,specifically targeting NHE1 and autosis for ventricular remodeling and heart failure after Ml in both diabetic and non-diabetic patients. | Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang | 2022 | Protein & Cell2022，13，5： | 13 |
| 10 | Assessing the Dynamics of Grassland Net Primary Productivity in Response to Climate Change at the Global Scale显示文摘Understanding the net primary productivity(NPP) of grassland is crucial to evaluate the terrestrial carbon cycle. In this study, we investigated the spatial distribution and the area of global grassland across the globe. Then, we used the Carnegie-Ames-Stanford Approach(CASA) model to estimate global grassland NPP and explore the spatio-temporal variations of grassland NPP in response to climate change from 1982 to 2008. Results showed that the largest area of grassland distribution during the study period was in Asia(1737.23 × 104 km^2), while the grassland area in Europe was relatively small(202.83 × 10~4 km^2). Temporally, the total NPP increased with fluctuations from 1982 to 2008, with an annual increase rate of 0.03 Pg C/yr. The total NPP experienced a significant increasing trend from 1982 to 1995, while a decreasing trend was observed from 1996 to 2008. Spatially, the grassland NPP in South America and Africa were higher than the other regions, largely as a result of these regions are under warm and wet climatic conditions. The highest mean NPP was recorded for savannas(560.10 g C/(m^2·yr)), whereas the lowest was observed in open shrublands with an average NPP of 162.53 g C/(m^2·yr). The relationship between grassland NPP and annual mean temperature and annual precipitation(AMT, AP, respectively) varies with changes in AP, which indicates that, grassland NPP is more sensitive to precipitation than temperature. | LIU Yangyang YANG Yue WANG Qian KHALIFA Muhammad ZHANG Zhaoying TONG Linjing LI Jianlong SHI Aiping | 2019 | Chinese Geographical Science2019，29，5： | 12 |
| 11 | Discriminating Potential of Extraintestinal Systemic Manifestations and Colonoscopic Features in Chinese Patients with Intestinal Beh~:et's Disease and Crohn's Disease显示文摘 | Ji Li Pan Li Jing Bai Hong Lyu Yue Li Hong Yang Bo Shen Jia-Ming Qian | 2015 | Chinese Medical Journal2015，，2： | 12 |
| 12 | Effects and safety of Sinomenine in treatment of rheumatoid arthritis contrast to methotrexate: a systematic review and Meta-analysis显示文摘OBJECTIVE: To systematically evaluate the curative clinical efficacy and safety of sinomenine(SIN) in treatment of rheumatoid arthritis(RA) in comparison to methotrexate(MTX).METHODS: We searched the China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang Database, Pubmed and Cochrane Library electronically up to August 31,2015, without language limitation. Only randomized controlled trials(RCTs) were included. Software Review Manager 5.3 was used for Meta-analysis.RESULTS: A total of 16 eligible studies within 1500RA patients were included. The meta-analysis indicated that on basis of MTX, SIN was more effective in total effective rate(P < 0.000 01). Besides, SIN alone versus MTX also showed advantages in RA therapy(P = 0.04) Taken together, adverse events occurred less frequently in combination of SIN and MTX than MTX alone(P < 0.0001), especially in digestive system(P < 0.000 01),while occurred more in dermato mucosal system with SIN treatment versus MTX(P = 0.02), and were similar for both remedies in nervous system(P = 0.12) and hematological system(P = 0.25).CONCLUTION: Compared to MTX, SIN had better clinical efficacy and relatively fewer adverse events in treatment of RA, especially when it was used together with MTX. Due to the poor methodological quality, well-designed, multiple-center RCTs are still required to further confirm the findings. | Liu Weiwei Qian Xian Ji Wei Lu Yan Wei Gang Wang Yue | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 12 |
| 13 | Coagulation behavior and floc properties of compound bioflocculant–polyaluminum chloride dual-coagulants and polymeric aluminum in low temperature surface water treatment显示文摘This study was intended to compare coagulation behavior and floc properties of two dualcoagulants polyaluminum chloride–compound bioflocculant(PAC–CBF)(PAC dose first) and compound bioflocculant–polyaluminum chloride(CBF–PAC)(CBF dose first) with those of PAC alone in low temperature drinking water treatment. Results showed that dualcoagulants could improve DOC removal efficiency from 30% up to 34%. Moreover, CBF contributed to the increase of floc size and growth rate, especially those of PAC–CBF were almost twice bigger than those of PAC. However, dual-coagulants formed looser and weaker flocs with lower breakage factors in which fractal dimension of PAC–CBF flocs was low which indicates a looser floc structure. The floc recovery ability was in the following order:PAC–CBF > PAC alone > CBF–PAC. The flocculation mechanism of PAC was charge neutralization and enmeshment, meanwhile the negatively charged CBF added absorption and bridging effect. | Xin Huang Shenglei Sun Baoyu Gao Qinyan Yue Yan Wang Qian Li | 2015 | Journal of Environmental Sciences2015，27，4： | 11 |
| 14 | Optimal proportion of wind and PV capacity in provincial power systems based on bilevel optimization algorithm under low-carbon economy显示文摘In order to boost contributions of power systems to a low-carbon economy,the installed capacity of renewable power generation,such as wind and photovoltaic(PV)power generation should be well planned.A bilevel formulation is presented to optimize the proportion of wind and PV capacity in provincial power systems,in which,carbon emissions of generator units and features of renewable resources are taken into account.In the lowerlevel formulation,a time-sequence production simulation(TSPS)model that is suitable for actual power system has been adopted.In order to maximize benefits of energy conservation and emissions reduction resulting from renewable power generation,the commercial software called General Algebraic Modeling System(GAMS)is employed to optimize the annual operation of the power system.In the upper-level formulation,the optimal pattern search(OPS)algorithm is utilized to optimize the proportion of wind and PV capacity.The objective of the upper-level formulation is to maximize benefits of energy conservation and carbon emissions reductions optimized in the lowerlevel problem.Simulation results in practical provincial power systems validate the proposed model and corresponding solving algorithms.The optimization results can provide support to policy makers to make the polices related to renewable energy. | Yue YUAN Yang CAO Xinsong ZHANG Chun LIU Yuehui HUANG Peng LI Kejun QIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 11 |
| 15 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 16 | Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink显示文摘背景 Gingerol 是为在生姜的刺鼻的成分的通用术语,它被报导了为禁止有效呕吐。我们试图在 minks.Methods 在物质 P 和 NK_1 受体上调查 gingerol 和它的有效机制的 antiemetic 效果 gingerol 的 antiemetic 效果在 cisplatin 导致的水貂在一个呕吐模型上在 6 小时的观察期间被调查,(7.5mg/kg, intraperitoneal ) 。在区域 postrema 和回肠的物质 P 和 NK_1 受体的分发被 immunohistochemistry 测量,并且在区域 postrema 和回肠的 NK_1 受体的表示被 cisplatin 的频率导致了干呕并且呕吐的西方的 blotting.Results 测量被预告的处理显著地以一种剂量依赖者方式与 gingerol 减少( P < 0.05 )。物质 P-immunoreactive 主要位于回肠以及在区域 postrema 的神经原的 mucosa 和 submucosa。 NK_1 受体的 immunoreactive 生产主要位于肌肉发达并且回肠的 submucosa 和区域 postrema 的神经原, gingerol 显著地压制了 cisplatin 以一种剂量依赖者方式导致的物质 P 和 NK_1 受体的增加的 immunoreactivity ( P < 0.05 ),并且 dose-dependently 在回肠和区域 postrema 在 NK_1 受体的增加的表示层次上展出了有效抑制( P < 0.05 ) .Conclusions Gingerol 对 导致cisplatin 的 emes | QIAN Qiu-hai YUE Wang CHEN Wen-hui YANG Zhi-hong LIU Zhan-tao WANG Yao-xia | 2010 | Chinese Medical Journal2010，，4： | 11 |
| 17 | Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation显示文摘Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment. | YUE WenTao1, ZHAO XiaoTing1, ZHANG LiNa1, LIU ZhiDong2, MA Li1, JIA WenYun1, QIAN Zhe1, ZHANG ChunYan1, WANG Yue1, YANG XueHui1 & XU ShaoFa2 1 Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China 2 Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China | 2010 | Science China(Life Sciences)2010，53，4： | 10 |
| 18 | Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression显示文摘 | Zhi-feng WEI Xiao-lan JIAO Ting WANG Qian LU Yu-feng XIA Zheng-tao WANG Qing-long GUO Gui-xin CHOU Yue DAI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 10 |
| 19 | Clinical and pathological features and imaging manifestations of bronchial anthracofibrosis: the findings in 15 patients显示文摘 | HAN Feng-feng YANG Tian-yun SONG Lin ZHANG Yue LI Hui-min GUAN Wen-bin LIU Qian GUO Xue-jun | 2013 | Chinese Medical Journal2013，，14： | 10 |
| 20 | Emerging transporter-targeted nanoparticulate drug delivery systems显示文摘Transporter-targeted nanoparticulate drug delivery systems(nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed,focusing on the specific transporter-based targeting strategies. Recent developments in transportermediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS. | Hongyan Su Yan Wang Shuo Liu Yue Wang Qian Liu Guangxuan Liu Qin Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员