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| 1 | Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through Sirt1显示文摘Perioperative hyperglycemia is a common metabolic disorder in clinic settings.Hyperglycemia leads to endothelial inflammation,endothelial cell apoptosis,and dysfunction,thus resulting in endothelial injury.Propofol(2,6-diisopropylphenol)is a widely used intravenous anesthetic in clinic settings.Our previous study indicated that propofol inhibits mitochondrial reactive oxygen species(ROS)production via down-regulation of phosphatase A2(PP2A)expression,inhibition of Ser36-p66shc dephosphorylation and mitochondrial translocation,thus improving high glucose-induced endothelial injury.The expression of p66shc was inhibited by propofol in hyperglycemic human umbilical vein endothelial cells(HUVECs).However,the mechanism by which propofol inhibits p66shc expression in hyperglycemic HUVECs is still obscure.In the present study,we mainly examined how propofol inhibited high glucose-induced p66shc expression in HUVECs.Compared with 5 mM glucose treatment,high glucose increased p66shc expression and decreased sirt1 expression,which was inhibited by propofol treatment.Moreover,EX527(a sirt1 inhibitor)reversed the effect of propofol against high glucose-induced p66shc expression.However,EX527 did not reverse the effects of propofol against high glucose-induced ROS accumulation,endothelial inflammation,and apoptosis.Furthermore,when cells were incubated with propofol,EX527,and FTY720(a PP2A activator)simultaneously,the effects of propofol against high glucose-induced ROS accumulation,inflammation,and apoptosis were reversed.Our results suggested that propofol inhibited high glucose-induced p66shc expression via upregulation of sirt1 expression in hyperglycemic HUVECs.Moreover,propofol protects against high glucose-mediated ROS accumulation and endothelial injury via both inhibition of p66shc expression and dephosphorylation of Ser36-p66shc. | Jing Wang Jie Qi Qichao Wu Hui Jiang Yuehao Yin Yan Huanx Yanjun Zhao Minmin Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 5 |
| 2 | Experimental demonstration of an Optical-Sectioning Compressive Sensing Microscope (CSM)显示文摘 | Yuehao Wu Peng Ye IftekharO Mirza | 2010 | OSA2010，18，24： | 1 |
| 3 | A combined interfacial and in-situ polymerization strategy to construct well-defined core-shell epoxy-containing SiO_(2) - based microcapsules with high encapsulation loading, super thermal stability and nonpolar solvent tolerance显示文摘SiO_(2)-based microcapsules containing hydrophobic molecules exhib-ited potential applications such as extrinsic self-healing,drug delivery,due to outstanding thermal and chemical stability of SiO_(2).However,to construct SiO_(2)-based microcapsules with both high encapsulation loading and long-term structural stability is still a troublesome issue,limiting their further utilization.We herein design asingle-batch route,a combined interfacial and in-situ polymerization strategy,to fabricate epoxy-containing SiO_(2)-based microcapsules with both high encapsu-lation loading and long-term structural stability.The final SiO_(2)-based microcapsules preserve high encapsulation loading of 85.7 wt% by controlling exclusively hydrolysis and condensed polymerization at oil/water interface in the initial interfacial polymerization step.In the subsequent in-situ polymerization step,the initial SiO_(2)-based microcapsules as seeds could efficiently harvest SiO_(2) precursors and primary SiO 2 particles to finely tune the SiO_(2) wall thickness,thereby enhancing long-term structural stability of the final SiO_(2)-based microcapsules including high thermal stability with almost no any weight loss until 250℃,and strong tolerance against nonpolar solvents such as CCl_(4) with almost unchanged core-shell structure and unchanged core weight after immersing into strong solvents for up to 5 days.These SiO_(2)-based microcapsules are extremely suited for processing them into anticorrosive coating in the presence of nonpolar solvents for self-healing application. | Yin Jia Haiyan Wang Kesong Tian Ruifei Li Zhaopeng Xu Jiao Jiao Ling Cao Yuehao Wu | 2016 | International Journal of Smart and Nano Materials2016，7，4： | 0 |
| 4 | Beam-focused SH wave transducer based on YSr_(3)(PO_(4))_(3)piezoelectric crystal for high temperature structural health monitoring显示文摘Guided-wave-based structural health monitoring(SHM)technology is of great importance for real-time inspection of high-temperature structures.The fundamental shear horizontal(SH_(0))wave is believed to be an ideal wave mode for developing SHM systems due to its nondispersive characteristics.However,currently very limited SH_(0)wave transducers can be used for SHM of high-temperature structures due to the limitation of materials.Herein,a novel YSr_(3)(PO_(4))_(3)(YSP)piezoelectric crystal in the space group I43d was grown.Experiments show that the face-shear piezoelectric coefficient d_(14)(d_(14)=d_(25)=d_(36))is 9.7 pC/N and varies little from 25 to 800℃.Then a beam-focused SH_(0)wave piezoelectric transducer is developed based on face-shear-mode YSP wafers.Both finite element simulations and experimental results indicate that the YSP-based transducer can excite pure SH_(0)wave and focus the wave energy along two opposite main directions.Especially,the obtained SH_(0)wave beam is highly concentrated with a small divergence angle of less than 30°,originating from the high working frequency range from 300 to 400 kHz.The excellent temperature stability of the as-grown YSP crystal makes the proposed SH_(0)wave piezoelectric transducer very suitable for SHM of high-temperature structures. | Yuehao Du Guangda Wu Fapeng Yu Hongchen Miao Xian Zhao | 2023 | Journal of Materiomics2023，9，3： | 0 |
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