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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Braking Performance of a Biomimetic Squid-Like Underwater Robot显示文摘 | Md. Mahbubar Rahman Sinpei Sugimori Hiroshi Miki Risa Yamamoto Yugo Sanada Yasuyuki Toda | 2013 | Journal of Bionic Engineering2013，10，3： | 13 |
| 3 | A 60 000-year loess-paleosol record of millennial-scale summer monsoon instability from Lanzhou, China显示文摘The 28-m high-resolution Shajinping loess section in Lanzhou on the Chinese western Loess Plateau records a detailed history of millennial Asian summer monsoon change since the earlier last glaciation. Summer monsoon proxies of soil magnetic susceptibility, carbonate content and soil color show that Asian summer monsoon experienced a series of rapid | Yugo Ono Hitoshi Fukusawa Keiichi Oi | 1999 | Chinese Science Bulletin1999，44，24： | 12 |
| 4 | Mitochondrial GPX1 silencing triggers differential photosynthesis impairment in response to salinity in rice plants显示文摘The physiological role of plant mitochondrial glutathione peroxidases is scarcely known. This study attempted to elucidate the role of a rice mitochondrial isoform(GPX1) in photosynthesis under normal growth and salinity conditions. GPX1 knockdown rice lines(GPX1s) were tested in absence and presence of 100 mM NaCl for 6 d.Growth reduction of GPX1 s line under non-stressful conditions, compared with non-transformed(NT) plants occurred in parallel to increased H_2O_2 and decreased GSH contents. These changes occurred concurrently with photosynthesis impairment, particularly in Calvin cycle's reactions, since photochemical efficiency did not change.Thus, GPX1 silencing and downstream molecular/metabolic changes modulated photosynthesis differentially. In contrast, salinity induced reduction in both phases of photosynthesis, which were more impaired in silenced plants.These changes were associated with root morphology alterations but not shoot growth. Both studied lines displayed increased GPX activity but H_2O_2 content did not change in response to salinity. Transformed plants exhibited lower photorespiration, water use efficiency and root growth, indicating that GPX1 could be important to salt tolerance. Growth reduction of GPX1 s line might be related to photosynthesis impairment, which in turn could have involved a cross talk mechanism between mitochondria and chloroplast originated from redox changes due to GPX1 deficiency. | Yugo Lima-Melo Fabricio E.L.Carvalho Márcio O.Martins Gisele Passaia Rachel H.V.Sousa Milton C.Lima Neto Márcia Margis-Pinheiro Joaquim A.G.Silveira | 2016 | Journal of Integrative Plant Biology2016，58，8： | 7 |
| 5 | 低排放柴油机燃烧的新概念显示文摘为了降低柴油机NO_x和颗粒排放,用数值模拟发动机试验和观察燃烧过程方法研究了柴油机燃烧的一种新概念。该概念(HiMICS:均质合理的多次喷射燃烧系统)为预混合压缩着火燃烧与多次喷射相结合的方式。用与标准的单次喷射和先导喷射的比较方法研究了HiMICS方式的燃烧特性。HiMICS方式要求在从进气行程早期到压缩行程中期这一时期内完成预先喷油形成预混合气。采用改进的KIVA-Ⅱ程序分析了每一种喷油模式对发动机性能和排放量的影响。模拟结果表明,HiMICS燃烧系统的燃油耗与NO_x排放量之间的折衷关系可获得显著的改进。为了证实模拟计算的结论,在一台装有共轨喷油系统的单缸试验机上完成了发动机试验。与模拟计算结论相反,试验表明,在正常喷油定时范围内,与标准喷油系统或先导喷油系统比较,HiMICS燃烧系统的NO_x和燃油耗之间以及NO_x和炭烟排放之间的折衷关系更为恶化。然而,从另一方面来说,当喷油定时相当大地推迟时,HiMICS燃烧系统在燃油耗和炭烟排放方面占优势,同时NO_x排放也相当低。需进一步解决的问题:预混合不够均匀,预混合气着火过早以及HC和CO排放量偏高。 | Haruyuki Yokota Yugo Kudo Hiroshi Naka jima 杨寿藏 | 1998 | 国外内燃机1998，30，3： | 5 |
| 6 | Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings显示文摘Basaloid squamous carcinoma(BSC)is a rare variant of esophageal cancer.There are very few reports of'early'BSC.Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy(NBI-ME).A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital.White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope.NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels.Iodine staining revealed a pale brown lesion.We performed endoscopic submucosal dissection for diagnostic treatment.Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320μm.The tumor cells formed solid nests and microcystic structures,containing an Alcian blue-positive mucoid matrix.The surface was covered with squamous epithelium without cellular atypia.Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium.Based on these findings together,we diagnosed the lesion as BSC.In this case,the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancerlike thick non-looped vessels.We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intraepithelial papilla and thick vessels around the tumor nests,respectively.These NBI-ME findings might be a feature of early esophageal BSC. | Yugo Kai Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Shinichiro Shinzaki Tsutomu Nishida Masahiko Tsujii Eiichi Morii Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 7 | Analysis of blasting damage in adjacent mining excavations显示文摘Following a small-scale wedge failure at Yukon Zinc's Wolverine Mine in Yukon, Canada, a vibration monitoring program was added to the existing rockbolt pull testing regime. The failure in the 1150 drift occurred after numerous successive blasts in an adjacent tunnel had loosened friction bolts passing through an unmapped fault. Analysis of blasting vibration revealed that support integrity is not compromised unless there is a geological structure to act as a failure plane. The peak particle velocity(PPV) rarely exceeded 250 mm/s with a frequency larger than 50 Hz. As expected, blasting more competent rock resulted in higher PPVs. In such cases, reducing the round length from 3.5 m to 2.0 m was an effective means of limiting potential rock mass and support damage. | Nick Yugo Woo Shin | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，3： | 3 |
| 8 | A high quality surface finish grinding process to produce total reflection mirror for x-ray fluorescence analysis显示文摘Total reflection x-ray fluorescence analysis is applied to trace element detection in liquid for effective environmental monitoring.This analytical approach requires x-ray total reflection mirrors.In order to achieve high sensitivity element detection,the mirrors require high surface quality for high x-ray reflectivity.Surface finishing for x-ray mirrors is typically conducted through a series of abrasive processes,such as grinding and polishing,and is thus time consuming.The purpose of this study is to streamline and enhance the surface finishing process based on unique high quality grinding techniques for the production of x-ray total reflection mirrors. | Hitoshi Ohmori Shinjiro Umezu Yunji Kim Yoshihiro Uehara Hiroshi Kasuga Teruko Kato Nobuhide Itoh Syuhei Kurokawa Takayuki Kusumi Yugo Sugawara Shinsuke Kunimura | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 9 | 地基多轴DOAS仪器的NO_2斜柱浓度对比研究显示文摘介绍了两台地基多轴DOAS仪器测量的NO2斜柱浓度的对比研究。利用日本海洋研究开发机构的一套多轴DOAS设备在2009年11月—12月31日期间16d的观测数据,与安光所自主研发的一套多轴DOAS设备测量的NO2差分斜柱浓度进行了对比。通过对比发现,采用自动调整积分时间的方法,与固定积分时间的设置相比仪器具有更高的信噪比;两套仪器的反演结果在小角度下具有比较好的一致性,相关系数高达0.995,但随着角度的增大相关性逐渐变差。在9点至16点时段内相对偏差较小,其中20°方向的结果最为接近,最小偏差仅有12%,但在9点前和16点后二者偏差增大。日方仪器在可见波段的反演结果明显好于紫外波段,反演中的剩余噪声减小了60%以上,同时在可见波段的差分斜柱浓度的计算结果与我们的多轴DOAS在紫外波段的计算结果在全天都具有非常好的一致性。 | 徐晋 谢品华 司福祺 李昂 窦科 刘文清 Yugo Kanaya Hitoshi Irie | 2012 | 光谱学与光谱分析2012，32，2： | 2 |
| 10 | Snowline elevation and eolian dust flux in the Japanese Islands during Isotope Stages 2 and 4显示文摘 | Yugo Ono Toshiro Naruse | 1996 | Quaternary International1996，，： | 1 |
| 11 | Hepatitis E Virus: Foodborne, Waterborne and Zoonotic Transmission显示文摘 | Yugo Danielle M Meng Xiang-Jin | 2013 | International Journal of Environmental Research and Public Health2013，，10： | 1 |
| 12 | Eco efficiency of Advanced Loop-closing Systems for Vehicles and Household Appliances in Hyogo Eco-town显示文摘 | Tohru Morioka Kiyotaka Tsumemi Yugo Yamamoto | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
| 13 | Eco-efficiency of Advanced Loop-closing Systems for Vehicles and Household Appliances In Hyogo Eco-town:A case Study of Solid Waste Management显示文摘 | TOHRU Morioka KIYOTAKA Tsunemi YUGO Yamamo-to | 2005 | Journal of In-dustrial Ecology2005，9，4： | 1 |
| 14 | RNA transcripts of full-length cDNA clones of rabbit hep- atitis E virus are infectious in rabbits 显示文摘 | COSSABOOM C M HUANG Y W YUGO D M | 2014 | J Gen Virol2014，，： | 1 |
| 15 | Characteristics of the synthesis of 15 - SiC by the implantation of carbon ions into silicon 显示文摘 | KIMUR T YUGO S KOMATSUBARA K F | 1982 | Thin Solid Films1982，94，6： | 1 |
| 16 | Cycle-closing product chain management with appropriate production site metabolism zero-emission in an industrial machinery corporation显示文摘 | Tohru Morioka Noboru Yoshida and Yugo Yamamoto | 2003 | Clean Technology Policy2003，，6： | 1 |
| 17 | 可见光驱动改性氮化碳无牺牲剂光催化析氢显示文摘载铂石墨氮化碳(g-C_(3)N_(4))是一种较好的可见光下催化析氢光催化剂.但催化水裂解需要牺牲电子供体,如三乙醇胺等.目前,无牺牲剂条件下g-C_(3)N_(4)的催化析氢仍是一个挑战.本文通过尿素热处理制备了氮化碳纳米片(NS-C_(3)N_(4)),并研究了其在可见光(λ>400 nm)下利用可逆电子给体无牺牲剂条件下析氢的光催化活性.在含有I−,Fe^(2+)或[Fe(CN)_(6)]^(4−)的水溶液中,负载铂的NS-C_(3)N_(4)上无H_(2)产生,用CrO_(x)改性Pt/NS-C_(3)N_(4)的光催化剂上可观察到H_(2)的析出.透射电镜和能量色散X射线光谱结果表明,在NS-C_(3)N_(4)上形成了Pt/CrO_(x)核壳结构.在[Fe(CN)_(6)]^(3−/4−)氧化还原介质存在下,CrO_(x)/Pt/NS-C_(3)N_(4)与改性WO_(3)光催化剂在可见光下共同催化水分解析氢. | Shunta Nishioka Kengo Shibata Yugo Miseki Kazuhiro Sayama Kazuhiko Maeda | 2022 | Chinese Journal of Catalysis2022，43，9： | 1 |
| 18 | Heterogeneous photocatalystmaterials for water splitting显示文摘 | Akihiko Kudo Yugo Miseki | 2009 | Chemistry Society Reviews2009，38，： | 1 |
| 19 | Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor显示文摘 | Kazuhiko Tatemoto Masaki Hosoya Yugo Habata Ryo Fujii Tadao Kakegawa Min-Xu Zou Yuji Kawamata Shoji Fukusumi Shuji Hinuma Chieko Kitada Tsutomu Kurokawa Haruo Onda Masahiko Fujino | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 20 | Generation of Diamond Nuclei by Electric Field in Plasma Chemical Vapor Deposition 显示文摘 | Yugo S Kanai T Kimura T | 1991 | Applied Physics Letters1991，58，10： | 1 |
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