|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of voltage.gated sodium channel Nav1.5 in non.metastatic colon cancer and its associations with estrogen receptor(ER)-βexpression and clinical outcomes显示文摘Background: Voltage-gated sodium channel 1.5(Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β(ER-β)expression in non-metastatic colon cancer patients receiving radical resection.Methods: A total of 269 consecutive patients with pathologically confirmed stages Ⅰ-Ⅲ colon cancer who underwent radical resection were selected. Nav1.5 and ER-β expression was detected by using immunohistochemistry(IHC)on tissue microarray constructed from paraffin-embedded specimens. IHC score was determined according to the percentage and intensity of positively stained cells. Statistical analysis was performed with the X-tile method, k coefficient, Chi square test or Fisher's exact test, logistic regression, log-rank test, and Cox proportional hazards models.Results: We found that Nav1.5 was commonly expressed in tumor tissues with higher mean IHC score as compared with matched tumor-adjacent normal tissues(5.1 ± 3.5 vs. 3.5 ± 2.7, P < 0.001).The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio(OR) = 2.980;95% confidential interval(CI)1.163-7.632; P = 0.023] and high ER-β expression(OR = 2.808; 95% CI 1.243-6.343;p = 0.00 3). Log-rank test results showed that high Nav1.5 expression contributed to a low 5-year disease-free survival(DFS) rate in colon cancer patients(77.2% vs. 92.1%, P = 0.048), especially in patients with high ER-β expression tumor(76.2% vs. 91.3%, P = 0.032). Analysis with Cox proportional hazards model demonstrated that high Nav1.5 expression[hazard ratio(HR) = 2.738; 95% CI 1.100-6.819;P = 0.030] and lymph node metastasis(HR = 2.633; 95% CI 1.632-4.248; P < 0.001) were prognostic factors for unfavorable DFS in colon cancer patients.Conclusions: High expression of Nav1.5 was associated with high expression of ER-β and indicated unfavorable oncologic prognosis in patients with non-metastatic colon cancer. | Jianhong Peng Qingjian Ou Xiaojun Wu Rongxin Zhang Qian Zhao Wu Jiang Zhenhai Lu Desen Wan Zhizhong Pan Yujing Fang | 2017 | Chinese Journal of Cancer2017，36，12： | 7 |
| 2 | G-ouadruplexes: targets in anticancer drug design 显示文摘 | OU Tianmiao LU Yujing TAN Jiaheng | 2008 | Chem Med Chem2008，3，5： | 1 |
| 3 | Submicron LaB_6 powders with high purity prepared in large scale by salt-assisted combustion synthesis显示文摘LaB6 powders were synthesized in large scale by salt-assisted combustion synthesis(CS) with different NaCl diluent contents. The variety of phases, particle size and purity of the powders were investigated using X-ray diffraction(XRD), scanning electron microscopy(SEM), energy dispersive spectrometer(EDS), and transmission electron microscope(TEM). With increase of NaCl content, the adiabatic combustion temperature of the reaction system linearly declines, the average particle size of leached products decreases, the impurity phases are easier to remove, and the products purity enhances obviously. When NaCl content is 40 wt%, the purity of the superfine powders of LaB_6 is more than 98 wt%, and the average particle size is 380 nm. | Zhengning Li Yujing Ou Peiqing La Yu Shi | 2018 | Journal of Rare Earths2018，36，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员