| 2 | A fast construction method for spatial index GBD-tree显示文摘This paper proposes a fast initial construction method of the GBD-tree. The GDB tree has proper characteristics for management of large amount of 2 or 3 dimensional data. However, the GBD-tree needs long initial construction time by originally proposed one-by-one insertion method. A fast insertion method has been proposed, but it needs large size of buffer capable to hold index information of all entries. The paper proposes another fast initial construction method. The method requires only limited size of work space (buffer). The experimental results show the initial construction time reduces into a third or a quarter of the one-by-one insertion method. The memory efficiency and retrieval efficiency are also improved than the one-by-one insertion method. | Yukio Negishi Yutaka Ohsawa Satoshi Takazawa | 2007 | 重庆邮电大学学报(自然科学版)2007，19，3： | 0 |
| 3 | 3,4-Oxo-isopropylidene-shikimic acid promotes adiopkine expression during murine 3T3-L1 fibroblast differentiation into adipocytes显示文摘Objective:3,4-Oxo-isopropylidene-shikimic acid(ISA),a derivative of shikimic acid,has exhibited ameliorative effect on cognitive impairment in experimental animal models of dementia.This study investigated the effect of ISA on lipid accumulation and adipokine secretion during differentiation of 3T3-L1 fibroblasts to adipocytes.Methods:3T3-L1 cells were cultured and treated with ISA(50e800 mM)from days 3e8.Lipid accumulation and triglyceride content were measured.Gene expression of adipokines(adiponectin,leptin,and resistin),CCAAT/enhancer binding protein(C/EBP)b,C/EBP a and peroxisome proliferator-activated receptor g(PPAR g)and PPAR target genes,including adipocyte fatty acid binding protein(aP2)and fatty acid synthase(FAS)were investigated.Results:ISA promoted 3T3-L1 fibroblast differentiation to adipocytes and increased triglyceride content by 26%.On mechanistic levels,ISA increased expressions of C/EBP b,PPAR g,C/EBP a,aP2 and FAS.Moreover,ISA stimulated expressions of adipokines secreted by adipocytes,including adiponectin,leptin,and resistin.Conclusions:These findings demonstrated that ISA promoted adipogenesis by up-regulating expressions of C/EBP b,PPAR g,C/EBP a,aP2 and FAS,and also stimulated adipokines during adipocyte differentiation.Further study should clarify the relationship between stimulation of adipokines and cognitive enhancing effect of ISA. | Shifen Dong Naomi Yasui Hiroko Negishi Ming Gao Yukio Yamori Katsumi Ikeda Jianning Sun | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，2： | 0 |
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