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| 1 | Genetics of macrovascular complications in type 2 diabetes显示文摘Type 2 diabetes mellitus(T2DM)is a metabolic disorder that currently affects more than 400 million worldwide and is projected to cause 552 million cases by the year 2030.Long-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic patients.The recent advances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial diseases.To date,the role of genetic and epigenetic factors in modulating susceptibility to T2DM and its vascular complications is being successfully studied that provides the accumulation of genomic knowledge.In the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in T2DM patients.This review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients. | Ziravard N Tonyan Yulia A Nasykhova Maria M Danilova Andrey S Glotov | 2021 | World Journal of Diabetes2021，12，8： | 2 |
| 2 | Nickel-catalysed electrochemical coupling between monoor di-chlorophenylphosphines and aryl or heteroaryl halides 显示文摘 | Yulia Budnikova Yuri Kargin Jean-Yves Nédélec and Jacques Périchon | 1999 | 575(1):63~661999，575，1： | 1 |
| 3 | Involvement of Notch1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines 显示文摘 | Yulia N Cheng P Y Melissa A | 2004 | Blood2004，103，9： | 1 |
| 4 | Involvement of Notch-1 signaling in bone marrow stroma mediated denovo drug resistance of myeloma and other malignant lymphoid cell lines显示文摘 | Yulia N Pingyan C Melissa A | 2004 | Blood2004，103，： | 1 |
| 5 | Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality显示文摘Background:In vitro production of bovine embryos is a well-established technology,but the in vitro culture(IVC)system still warrants improvements,especially regarding embryo quality.This study aimed to evaluate the effect of extracellular vesicles(EVs)isolated from oviductal(OF)and uterine fluid(UF)in sequential IVC on the development and quality of bovine embryos.Zygotes were cultured in SOF supplemented with either BSA or EVs-depleted fetal calf serum(dFCS)in the presence(BSA-EV and dFCS-EV)or absence of EVs from OF(D1 to D4)and UF(D5 to D8),mimicking in vivo conditions.EVs from oviducts(early luteal phase)and uterine horns(mid-luteal phase)from slaughtered heifers were isolated by size exclusion chromatography.Blastocyst rate was recorded on days 7-8 and their quality was assessed based on lipid contents,mitochondrial activity and total cell numbers,as well as survival rate after vitrification.Relative mRNA abundance for lipid metabolism-related transcripts and levels of phosphorylated hormonesensitive lipase(pHSL)proteins were also determined.Additionally,the expression levels of 383 miRNA in OF-and UF-EVs were assessed by qRT-PCR.Results:Blastocyst yield was lower(P<0.05)in BSA treatments compared with dFCS treatments.Survival rates after vitrification/warming were improved in dFCS-EVs(P<0.05).EVs increased(P<0.05)blastocysts total cell number in dFCS-EV and BSA-EV compared with respective controls(dFCS and BSA),while lipid content was decreased in dFCSEV(P<0.05)and mitochondrial activity did not change(P>0.05).Lipid metabolism transcripts were affected by EVs and showed interaction with type of protein source in medium(PPARGC1B,LDLR,CD36,FASN and PNPLA2,P<0.05).Levels of pHSL were lower in dFCS(P<0.05).Twenty miRNA were differentially expressed between OF-and UF-EVs and only bta-miR-148b was increased in OF-EVs(P<0.05).Conclusions:Mimicking physiological conditions using EVs from OF and UF in sequential IVC does not affect embryo development but improves blastocyst quality regarding survival rate after vitrification/warming,total cell number,lipid content,and relative changes in expression of lipid metabolism transcripts and lipase activation.Finally,EVs miRNA contents may contribute to the observed effects. | Cláudia Lima Verde Leal Karina Canón-Beltrán Yulia N.Cajas Meriem Hamdi Aracelli Yaryes María Gemma Millán de la Blanca Paula Beltrán-Brena Rosane Mazzarella Juliano Coelho da Silveira Alfonso Gutiérrez-Adán Encina M González Dimitrios Rizos | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 6 | Taxonomic Composition and Spatial Distribution of Meiofauna Community from a Sandy Intertidal Zone in Sishili Bay, Yellow Sea Coast (Northern China)显示文摘The meiofauna composition and trophic groups of the nematode communities have been studied at a sandy intertidal zone in Sishili Bay along the Yantai coast(Yellow Sea,China).Nematoda was dominant among the 11 groups of meiofauna.The meiofaunal densities were low,ranging between 111±47 and 542±131 ind./10 cm^(2).Results obtained from the correlation analysis made it possible to determine several factors that influence species composition and distribution.Generally,sediment granulometry significantly affected the communities.The highest abundance was found in fine-grained sediments(318.77±126 ind./10 cm^(2))com-pared to coarse-grained sediments(175±82 ind./10 cm2).Nematodes were predominant in all studied sites.A total of 70 species be-longing to 52 genera and 18 families were identified in the study area.There was a significant difference in nematode abundance(ANOVA,F=2.38,P<0.05)between the three sites.Nematode communities were characterized by a high level of species diversity in sediments composed mainly of very-fine sands(>63μm),with dominant species belonging to the genus Bathylaimus,Ptycho-laimellus,Spirinia,and Sabatieria.The trophic groups were dominated by non-selective deposit feeders(40.7%)and epistrate feed-ers(41.29%).In contrast,the species composition in medium grain sands was characterized by a low species diversity index and a high Simpson dominance index.Nematode communities showed similar dominant species compositions belonging to a single genus Bathylaimus,Enoplolaimus,and Oncholaimus,and in terms of trophic structure-representatives of deposit feeders(46.15%),preda-tors,and omnivores(64.71%)prevailed.The divergence of meiofaunal community structures can be explained by abiotic factors such as sediment grain size,salinity,and organic carbon content.Specifically,sediment particle size can explain the diversity of nematodes at the level of in abundance,diversity indices,and trophic structure.The highest nematode density and diversity coincided with the highest percentage of very fine sands. | PAVLYUK Olga N TREBUKHOVA Yulia A SHCHERBAKOV Ilya A TARASOVA Tatiana S LUTAENKO Konstantin A CHEN Linlin SONG Bo LI Xiaojing LI Baoquan | 2022 | Journal of Ocean University of China2022，21，5： | 0 |
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