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您的检索式：作者名="Yumeng Tan"
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| 1 | Glycosyltransferases:Mining,engineering and applications in biosynthesis of glycosylated plant natural products显示文摘UDP-Glycosyltransferases(UGTs)catalyze the transfer of nucleotide-activated sugars to specific acceptors,among which the GT1 family enzymes are well-known for their function in biosynthesis of natural product glycosides.Elucidating GT function represents necessary step in metabolic engineering of aglycone glycosylation to produce drug leads,cosmetics,nutrients and sweeteners.In this review,we systematically summarize the phylogenetic distribution and catalytic diversity of plant GTs.We also discuss recent progress in the identifi-cation of novel GT candidates for synthesis of plant natural products(PNPs)using multi-omics technology and deep learning predicted models.We also highlight recent advances in rational design and directed evolution engineering strategies for new or improved GT functions.Finally,we cover recent breakthroughs in the appli-cation of GTs for microbial biosynthesis of some representative glycosylated PNPs,including flavonoid glycosides(fisetin 3-O-glycosides,astragalin,scutellarein 7-O-glucoside),terpenoid glycosides(rebaudioside A,ginseno-sides)and polyketide glycosides(salidroside,polydatin). | Bo He Xue Bai Yumeng Tan Wentao Xie Yan Feng Guang-Yu Yang | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 2 |
| 2 | In situ phosphonium-containing Lewis basecatalyzed 1,6-cyanation reaction:a facile way to obtainα-diaryl andα-triaryl acetonitriles显示文摘We present a phosphonium-containing catalyst generated in situ from phosphine and tert-butyl acrylate that serves as an unusual Lewis base catalyst.It was applied for the promotion of a remote 1,6-cyanation reaction of p-quinone methides and fuchsones employing trimethylsilyl cyanide as the cyanide source.A diverse range ofα-diaryl andα-triaryl acetonitriles was obtained in high yields under mild reaction conditions with low catalyst loading(5 mol%).The practicality and utility of this protocol were demonstrated via the gram-scale preparation and facile elaboration of products.Mechanistic investigations(in situ NMR and ESI-MS analysis)were employed to characterize the active zwitterionic phosphonium intermediate,which was the“true”active catalyst. | Jian-Ping Tan Yuan Chen Xiaoyu Ren Yumeng Guo Bing Yi Hongkui Zhang Guowei Gao Tianli Wang | 2022 | Organic Chemistry Frontiers2022，9，1： | 0 |
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