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| 1 | Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives显示文摘Biodegradable metals(BMs)gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body.Complete dissolution of biodegradable implants assists tissue healing,with no implant residues in the surrounding tissues.In recent years,three classes of BMs have been extensively investigated,including magnesium(Mg)-based,iron(Fe)-based,and zinc(Zn)-based BMs.Among these three BMs,Mg-based materials have undergone the most clinical trials.However,Mg-based BMs generally exhibit faster degradation rates,which may not match the healing periods for bone tissue,whereas Fe-based BMs exhibit slower and less complete in vivo degradation.Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates,which fall between those of Mg-based BMs and Fe-based BMs,thus requiring extensive research to validate their suitability for biomedical applications.In the present study,recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs.The underlying roles of alloy composition,microstructure,and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed. | Humayun Kabir Khurram Munir Cuie Wen Yuncang Li | 2021 | Bioactive Materials2021，6，3： | 18 |
| 2 | Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2显示文摘MicroRNAs (miRNAs ) 是与癌症的致病有关的小非编码的 RNA 并且仔细的一个班。增加的证据显示 miR-30a 在癌症的发展期间起一个深刻作用。然而,在 non-small-cell 肺癌症(NSCLC ) 的 miR-30a 的功能仍然是模糊的。这里,我们发现 miR-30a 被 qRT-PCR 从 14 个病人在肺腺癌 A549 房间并且在织物样品减少,并且也发现在 A549 房间的 miR-30a 的 overexpression 由愈合创伤的试金禁止了移植和侵略然而并非房间增长和房间周期前进, matrigel 侵略试金,基于山的房间增长试金,和流动 基于cytometry 的房间周期分析分别地。我们进一步在肺腺癌房间行探索了 miR-30a-mediated 基因规定的潜在的机制。EYA2 是 miR-30a 的一个预言的目标,并且 EYA2 表示被 miR-30a 在乳癌房间禁止,这被发现了。我们证明 EYA2 是由在 A549 房间使用双酶的记者试金的 miR-30a 的一个直接目标并且证明 EYA2 蛋白质层次相反地在 A549 和 BEAS-2B 房间与 miR-30a 表示被相关。另外,我们也与表示向量和 miR-30a 模仿的 EYA2 由 cotransfection 在 A549 房间证实了 EYA2 overexpression 的营救效果。一起拿,我们的结果证明在肺腺癌 A549 房间的 miR-30a 的 overexpression 能禁止房间移植和侵略,它部分被归因于 EYA2 的减少表示。我们的调查结果建议 miR-30a 以后可以为肺腺癌的治疗被用作一个新潜在的目标。 | Yuncang Yuan Shangyong Zheng Qian Li Xudong Xiang Tangxin Gao Pengzhan Ran Lijuan Sun Qionglin Huang Fei Xie Jing Du Chunjie Xiao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 12 |
| 3 | Additive manufacturing of metallic and polymeric load-bearing biomaterials using laser powder bed fusion:A review显示文摘Surgical prostheses and implants used in hard-tissue engineering should satisfy all the clinical,mechanical,manufacturing,and economic requirements in order to be used for load-bearing applications.Metals,and to a lesser extent,polymers are promising materials that have long been used as load-bearing biomaterials.With the rapid development of additive manufacturing(AM)technology,metallic and polymeric implants with complex structures that were once impractical to manufacture using traditional processing methods can now easily be made by AM.This technology has emerged over the past four decades as a rapid and cost-effective fabrication method for geometrically complex implants with high levels of accuracy and precision.The ability to design and fabricate patient-specific,customized structural biomaterials has made AM a subject of great interest in both research and clinical settings.Among different AM methods,laser powder bed fusion(L-PBF)is emerging as the most popular and reliable AM method for producing load-bearing biomaterials.This layer-by-layer process uses a high-energy laser beam to sinter or melt powders into a part patterned by a computer-aided design(CAD)model.The most important load-bearing applications of L-PBF-manufactured biomaterials include orthopedic,traumatological,craniofacial,maxillofacial,and dental applications.The unequalled design freedom of AM technology,and L-PBF in particular,also allows fabrication of complex and customized metallic and polymeric scaffolds by altering the topology and controlling the macro-porosity of the implant.This article gives an overview of the L-PBF method for the fabrication of load-bearing metallic and polymeric biomaterials. | Alireza Nouri Anahita Rohani Shirvan Yuncang Li Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，35： | 9 |
| 4 | Graphene nanoplatelets-reinforced magnesium metal matrix nanocomposites with superior mechanical and corrosion performance for biomedical applications显示文摘Magnesium(Mg)metal matrix composites(MMCs)reinforced with graphene nanoplatelets(GNPs)have been developed by powder metallurgy(PM).GNPs with different concentrations(0.1,0.2,and 0.3 wt.%),layer thicknesses(5 nm and 9 nm),and particle sizes(15μm and 5μm)were dispersed into Mg powder by high-energy ball-milling processes.The microstructure and mechanical properties of the fabricated composites were characterized using transmission electron microscopy(TEM),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDX),X-ray diffraction(XRD),Raman spectroscopy(RS),and compression tests.The corrosion resistance was evaluated by electrochemical tests and hydrogen evolution measurements.The cytotoxicity of Mg-GNPs composites was assessed using osteoblast-like SaOS2 cells.The results indicate that GNPs are excellent candidates as reinforcements in Mg matrices for the manufacture of biodegradable Mg-based composite implants.GNP addition improved the mechanical properties of Mg via synergetic strengthening modes.Moreover,retaining the structural integrity of GNPs during processing improved the ductility,compressive strength,and corrosion resistance of the Mg-GNP composites.Cytotoxicity assessments did not reveal any significant toxicity with the addition of GNPs to Mg matrices.This study demonstrates that Mg-xGNPs with x<0.3 wt.%,may constitute novel biodegradable implant materials for load-bearing applications. | Khurram Munir Cuie Wen Yuncang Li | 2020 | Journal of Magnesium and Alloys2020，8，1： | 8 |
| 5 | A review of high-strength nanolaminates and evaluation of their properties显示文摘Nanolaminates are composed of nanoscale-thick alternating layers of different materials and their properties are dependent on the individual layers,the layer thickness and the interfaces between the layers.Nanolaminates composed of cubic crystal structured metals are usually ductile compared to nanolaminates containing hexagonal crystal structured metals.Mechanical properties such as strength and hardness of nanolaminates increase with a decrease in individual layer thickness down to a few nanometers and they become independent when the thickness of individual layers is less than a couple of nanometers.This review provides a detailed analysis of the effects of individual layer thickness and the interface structures on the strength and the strengthening mecha nisms of nanolaminates,their ductility and fracture behavior in terms of structural variations including grain morphologies,nanotwins,amorphous phases and crystal structures of the layers.The principles for designing nanolaminates with exceptionally high mechanical and physical properties and their fabrication are also highlighted.Some contradictory issues such as strengthening mechanisms,elastic modulus dependency on individual layer thickness and the effect of a thin amorphous layer on the strength are discussed.This review also provides future research directions in designing the high-strength nanolaminates that will facilitate practical engineering applications through analyzing up-to-date research efforts. | Mohammad Nasim Yuncang Li Ming Wen Cuie Wen | 2020 | Journal of Materials Science & Technology2020，47，15： | 6 |
| 6 | HA coating on Mg alloys for biomedical applications:A review显示文摘Magnesium(Mg)alloys are receiving increasing attention as biodegradable implant materials in recent years.However,their low corrosion resistance and fast degradation in the physiological environment remain challenges for a widespread application.Hydroxyapatite(HA)coating on Mg alloys can enhance their corrosion resistance,biocompatibility,and bioactivity of the Mg alloy substrates since the compositions of HA are similar to those of the hard tissue of natural bone.This review analyzes the challenges of Mg alloys for biomedical applications,the fundamental requirements for biodegradable metals,and the corrosion mechanisms of Mg alloys in the physiological environment.The benefits of HA coatings on Mg alloys,the most commonly used surface coating techniques and their advantages and limitations,and the in vitro and in vivo performance of Mg alloys with and without surface coatings are comprehensively elucidated.Multistep processes such as alkali treatment and then HA coating by electrochemical deposition on Mg alloys appear to be necessary to achieve a satisfactory surface coating on Mg alloys,which has been demonstrated to have the potential to improve the degrading behavior,bioactivity and biocompatibility.Multifunctional coatings are most effective in achieving safe and bioactive Mg alloy surfaces for promising biodegradable implant applications. | Mostafizur Rahman Yuncang Li Cuie Wen | 2020 | Journal of Magnesium and Alloys2020，8，3： | 4 |
| 7 | A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications显示文摘The application of various materials in biomedical procedures has recently experienced rapid growth.One area that is currently receiving significant attention from the scientific community is the treatment of a number of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites.Biomaterials,the most common materials used to repair or replace damaged parts of the human body,can be categorized into three major groups:metals,ceramics,and polymers.Composites can be manufactured by combining two or more materials to achieve enhanced biocompatibility and biomechanical properties for specific applications.Biomaterials must display suitable properties for their applications,about strength,durability,and biological influence.Metals and their alloys such as titanium,stainless steel,and cobalt-based alloys have been widely investigated for implant-device applications because of their excellent mechanical properties.However,these materials may also manifest biological issues such as toxicity,poor tissue adhesion and stress shielding effect due to their high elastic modulus.To mitigate these issues,hydroxyapatite(HA)coatings have been used on metals because their chemical composition is similar to that of bone and teeth.Recently,a wide range of synthetic polymers such as poly(L-lactic acid)and poly(L-lactide-co-glycolide)have been studied for different biomedical applications,owing to their promising biocompatibility and biodegradability.This article gives an overview of synthetic polymer-ceramic composites with a particular emphasis on calcium phosphate group and their potential applications in tissue engineering.It is hoped that synthetic polymer-ceramic composites such as PLLA/HA and PCL/HA will provide advantages such as eliminating the stress shielding effect and the consequent need for revision surgery. | Mona Alizadeh-Osgouei Yuncang Li Cuie Wen | 2019 | Bioactive Materials2019，4，1： | 3 |
| 8 | Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications显示文摘Zinc(Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys under three different conditions of as-cast(AC),hot-rolling(HR), and hot-rolling plus cold-rolling(HR + CR). The HR + CR Zn–3 Cu–0.2 Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn–3 Cu exhibited the highest degradation rate of 23.9 m/a. Friction and wear testing of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn–3 Cu–0.2 Ti showed the highest wear resistance.The diluted extracts of HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti at a concentration of ≤25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti exhibited effective antibacterial properties against S. aureus. | Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 9 | Nano-tribological behavior of graphene nanoplatelet-reinforced magnesium matrix nanocomposites显示文摘The corrosion resistance and wear resistance of metallic biomaterials are critically important for orthopedic hard-tissue replacement applications because the lack of such properties not only adversely affects their mechanical integrity but also allows the release of wear debris into the human body.In this study,the potential of zirconium(Zr)as an alloying element and graphene nanoplatelets(GNPs)as a nano-reinforcement material were investigated in relation to improving the tribological performance of pure magnesium(Mg).The GNPs-reinforced Mg matrix nanocomposites(MNCs)were fabricated using powder metallurgy.Results indicate that additions of 0.5 wt.%Zr and0.1 wt.%GNPs to Mg matrices significantly improved the wear resistance by 89%and 92%at 200μN load,60%and 80%at 100μN load,and 94%and 93%at 50μN load,respectively,as compared to the wear resistance of pure Mg.The wear depth and coefficient of friction of the MNC containing 0.5 wt.%Zr and 0.1 wt.%GNPs(Mg0.5 Zr0.1 GNPs MNC)were considerably reduced as compared to pure Mg and Mg0.5 Zr.Our results demonstrate that the Mg0.5 Zr0.1 GNPs MNC is promising for orthopedic applications in relation to its excellent tribological performance. | Mohammad Shahin Khurram Munir Cuie Wen Yuncang Li | 2021 | Journal of Magnesium and Alloys2021，9，3： | 2 |
| 10 | Mechanical properties and bioactive surface modification via alkali-heat treatment of a porous Ti–18Nb–4Sn alloy for biomedical applications显示文摘 | Jianyu Xiong Yuncang Li Xiaojian Wang Peter Hodgson Cui’e Wen | 2008 | Acta Biomaterialia2008，，6： | 1 |
| 11 | Biocompatibility of boron nitride nanosheets显示文摘硼氮化物(BN ) 的性质和应用程序 nanosheets 对 graphene 的那些补足,与在化学、热的稳定性的优点。Biocompatibility 是为未来的一个重要性质生物医学的应用程序但是没试验性地被调查。我们学习了不同尺寸的 BN nanosheets 的 biocompatibility 并且在像造骨细胞的房间把它与 BN nanoparticles 的作比较(SaOS 2) 。我们的结果证明 BN nanomaterials 的 biocompatibility 取决于他们的尺寸,形状,结构,和表面化学药品性质。电子旋转回声测量表明在 nanosheet 边或在粒子表面上定位的不饱和的 B 原子为在新窗户中的房间 death.Open | Srikanth Mateti Cynthia S. Wong Zhen Liu Wenrong Yang Yuncang Li Lu Hua Li Ying Chen | 2018 | Nano Research2018，11，1： | 1 |
| 12 | Additive manufacturing of antibacterial PLA-ZnO nanocomposites:Benefits,limitations and open challenges显示文摘Polymeric biomaterials such as polylactic acid(PLA)play a prominent role in the advancement of biomedical additive manufacturing(AM).PLA offers indeed a very advantageous combination of thermomechanical properties and functional attributes,as it is biobased,biodegradable,biocompatible and easy to print.However,PLA can be damaged by common sterilization methods and is sensitive to most chemical disinfectants,and this may impair its widespread usage.One of the most promising ways to overcome this shortcoming is to provide PLA with embedded antibacterial activity by the addition of appropriate fillers such as zinc oxide(Zn O)nanoparticles.After a detailed introduction to the basic properties of PLA and ZnO nanoparticles,the present review analyzes the main variables that govern the antibacterial activity of PLA-ZnO nanocomposites.Current applications and related manufacturing processes are also presented to showcase the importance of having embedded antibacterial functions in demanding applications such as food packaging and wound dressing.Emphasis is then placed on the emerging literature of the AM of PLA-ZnO nanocomposites,with a focus on fused filament fabrication(also known as fused deposition modeling).Existing gaps and hurdles related to the development and 3D printing of such composites is critically discussed.It is envisioned that a deeper understanding of the processability,thermo-mechanical behavior,biocompatibility and antibacterial efficacy of additively manufactured PLAZnO nanocomposites will foster their adoption in the biomedical field and,ultimately,in all circumstances where it is crucial to limit infection transmission. | Wei Juene Chong Shirley Shen Yuncang Li Adrian Trinchi Dejana Pejak Ilias(Louis)Kyratzis Antonella Sola Cuie Wen | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 13 | Study on the new type of solar adsorption refrigeration system 显示文摘 | Li Yuncang Eric Hu J | 2000 | New energy2000，22，11： | 1 |
| 14 | Microstructures, mechanical properties, corrosion, and biocompatibility of extruded Mg-Zr-Sr-Ho alloys for biodegradable implant applications显示文摘In this study,the microstructures,mechanical properties,corrosion behaviors,and biocompatibility of extruded magnesium-zirconiumstrontium-holmium(Mg-Zr-Sr-Ho)alloys were comprehensively investigated.The effect of different concentrations of Ho on the microstructural characteristics,tensile and compressive properties,corrosion resistance,and biocompatibility were investigated.The microstructures of the extruded Mg-1Zr-0.5Sr-xHo(x=0.5,1.5,and 4 wt.%)alloys consisted ofα-Mg matrix,fineα-Zr particles,and intermetallic phase particles of Mg_(17)Sr_(2) and Ho_(2)Mg mainly distributed at the grain boundaries.Extensive{1012}tensile twins were observed in the partially recrystallized samples of Mg-1Zr-0.5Sr-0.5Ho and Mg-1Zr-0.5Sr-1.5Ho.Further addition of Ho to 4 wt.%resulted in a complete recrystallization due to activation of the particle stimulated nucleation around the Mg_(17)Sr_(2) particles.The evolution of a rare earth(RE)texture was observed with the Ho addition,which resulted in the weakened basal and prismatic textures.Furthermore,a drastic increase of 200%in tensile elongation and 89%in compressive strain was observed with Ho addition increased from 0.5 to 4 wt%,respectively.The tension-compression yield asymmetry was significantly decreased from 0.62 for Mg-1Zr-0.5Sr-0.5Ho to 0.98 for Mg-1Zr-0.5Sr-4Ho due to the weakening of textures.Corrosion analysis of the extruded Mg-Zr-Sr-Ho alloys revealed the presence of pitting corrosion.A minimum corrosion rate of 4.98 mm y^(−1) was observed in Mg-1Zr-0.5Sr-0.5Ho alloy.The enhanced corrosion resistance is observed due to the presence of Ho_(2)O_(3) in the surface film which reduced galvanic effect.The formation of a stabilized surface film due to the Ho_(2)O_(3) was confirmed through the electrical impedance spectroscopy and XPS analysis.An in vitro cytotoxicity assessment revealed good biocompatibility and cell adhesion in relation to SaOS2 cells. | Faisal Kiani Jixing Lin Alireza Vahid Khurram Munir Cuie Wen Yuncang Li | 2023 | Journal of Magnesium and Alloys2023，11，1： | 1 |
| 15 | Titanium-niobium pentoxide composites for biomedical applications显示文摘The strength of titanium scaffolds with the introduction of high porosity decreases dramatically and may become inadequate for load bearing in biomedical applications.To simultaneously meet the requirements of biocompatibility,low elastic modulus and appropriate strength for orthopedic implant materials,it is highly desirable to develop new biocompatible titanium based materials with enhanced strength.In this study,we developed a niobium pentoxide(Nb2O5)reinforced titanium composite via powder metallurgy for biomedical applications.The strength of the Nb2O5 reinforced titanium composites(Ti-Nb2O5)is significantly higher than that of pure titanium.Cell culture results revealed that the Ti-Nb2O5 composite exhibits excellent biocompatibility and cell adhesion.Human osteoblast-like cells grew and spread healthily on the surface of the Ti-Nb2O5 composite.Our study demonstrated that Nb2O5 reinforced titanium composite is a promising implant material by virtue of its high mechanical strength and excellent biocompatibility. | Yuncang Li Khurram S.Munir Jixing Lin Cuie Wen | 2016 | Bioactive Materials2016，1，2： | 1 |
| 16 | Mechanical properties and bioactive surface modification via alkali-heat treatment of a porous Ti–18Nb–4Sn alloy for biomedical applications显示文摘 | Jianyu Xiong Yuncang Li Xiaojian Wang Peter Hodgson Cui’e Wen | 2008 | Acta Biomaterialia2008，，6： | 1 |
| 17 | Development of Ti-26Nb-1.2TiC shape memory composite for biomedical applications显示文摘Ti-Nb alloys have great potential in biomedical applications as bone-implant materials due to their low elastic modulus,superelasticity,high corrosion resistance,and good biocompatibility.However,the low yield strength and poor superelasticity of Ti-Nb alloys restrict their practical clinical applications.Here,we report the mechanical properties and superelasticity,corrosion behavior,and biocompatibility of a Ti-26 at.%Nb-1.2 vol.%TiC(Ti-26Nb-1.2TiC)shape memory composite(SMC)prepared by vacuum arc melting and hot rolling.The yield strength,critical stress for inducing martensitic transformation,and elongation of the Ti-26Nb-1.2TiC SMC and a Ti-26Nb alloy were 460 and 337 MPa,251 and 115 MPa,and 27.2%and 24.1%,respectively.The recovery rate of the SMC under 4%pre-strain reached 91.4%,which was 1.2 times that of the Ti-26Nb.Electrochemical tests in Hanks’solution revealed that the corrosion current density,passive current density,and corrosion rate of the SMC were lower than those of the Ti-26Nb.Both the Ti-26Nb alloy and Ti-26Nb-1.2TiC SMC showed good cell viability with grade 0 cytotoxicity in relation to MG-63 osteosarcoma cells. | Quanxiang Sun Dechuang Zhang Xian Tong Jianguo Lin Jixing Lin Yuncang Li Cuie Wen | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 18 | Mechanical and corrosion properties of graphene nanoplatelet–reinforced Mg–Zr and Mg–Zr–Zn matrix nanocomposites for biomedical applications显示文摘Magnesium(Mg)-based biomaterials have gained acceptability in fracture fixation due to their ability to naturally degrade in the body after fulfilling the desired functions.However,pure Mg not only degrades rapidly in the physiological environment,but also evolves hydrogen gas during degradation.In this study,Mg0.5Zr and Mg0.5ZrxZn(x=1–5 wt.%)matrix nanocomposites(MNCs)reinforced with different contents(0.1–0.5 wt.%)of graphene nanoplatelets(GNP)were manufactured via a powder metallurgy technique and their mechanical and corrosion properties were evaluated.The increase in GNP concentration from 0.2 wt.%to 0.5 wt.%added to Mg0.5Zr matrices resulted in decreases in the compressive yield strength and corrosion resistance in Hanks’Balanced Salt Solution(HBSS).On the other hand,a higher concentration(4–5 wt.%)of Zn added to Mg0.5Zr0.1GNP resulted in an increase in ductility but a decrease in compressive yield strength.Overall,an addition of 0.1 wt.%GNPs to Mg0.5Zr3Zn matrices gave excellent ultimate compressive strength(387 MPa)and compressive yield strength(219 MPa).Mg0.5Zr1Zn0.1GNP and Mg0.5Zr3Zn0.1GNP nanocomposites exhibited 29%and 34%higher experimental yield strength,respectively,as compared to the theoretical yield strength of Mg0.5Zr0.1GNP calculated by synergistic strengthening mechanisms including the difference in thermal expansion,elastic modulus,and geometry of the particles,grain refinement,load transfer,and precipitation of GNPs in the Mg matrices.The corrosion rates of Mg0.5Zr1Zn0.1GNP,Mg0.5Zr3Zn0.1GNP,Mg0.5Zr4Zn0.1GNP,and Mg0.5Zr5Zn0.1GNP measured using potentiodynamic polarization were 7.5 mm/y,4.1 mm/y,6.1 mm/y,and 8.0 mm/y,respectively.Similarly,hydrogen gas evolution tests also demonstrated that Mg0.5Zr3Zn0.1GNP exhibited a lower corrosion rate(1.5 mm/y)than those of Mg0.5Zr1Zn0.1GNP(3.8 mm/y),Mg0.5Zr4Zn0.1GNP(1.9 mm/y),and Mg0.5Zr5Zn0.1GNP(2.2 mm/y).This study demonstrates the potential of GNPs as effective nano-reinforcement particulates for improving the mechanical and corrosion properties of Mg–Zr–Zn matrices. | Mohammad Shahin Cuie Wen Khurram Munir Yuncang Li | 2022 | Journal of Magnesium and Alloys2022，10，2： | 0 |
| 19 | Binary Zn–Ti alloys for orthopedic applications:Corrosion and degradation behaviors,friction and wear performance,and cytotoxicity显示文摘Zinc(Zn)and its biocompatible and biodegradable alloys have substantial potential for use in orthopedic implants.Nevertheless,pure Zn with a hexagonal close-packed crystal structure has only two independent slip systems,therefore exhibiting extremely low elongation and yield strength in its ascast condition,which restricts its clinical applications.In this study,as-cast Zn–xTi(titanium)(x=0.05,0.10,0.20,and 0.30 wt.%)binary alloys were hot-rolled and their microstructures,mechanical properties,wear resistance,and cytocompatibility were comprehensively investigated for orthopedic implant applications.The microstructures of both as-cast and hot-rolled Zn–xTi alloys consisted of anα-Zn matrix phase and a TiZn16 phase,while Zn–0.2 Ti and Zn–0.3 Ti exhibited a finerα-Zn phase due to the grainrefining effect of Ti.The hot-rolled Zn–0.2 Ti alloy exhibited the highest yield strength(144.5 MPa),ultimate strength(218.7 MPa),and elongation(54.2%)among all the Zn–x Ti alloys.The corrosion resistance of Zn–xTi alloys in Hanks’solution decreased with increasing addition of Ti,and the hot-rolled Zn–0.3 Ti alloy exhibited the highest corrosion rates of 432μm/y as measured by electrochemical testing and 57.9μm/y as measured by immersion testing.The as-cast Zn–xTi alloys showed lower wear losses than their hot-rolled counterparts.The extracts of hot-rolled Zn–x Ti alloys at concentrations of≤25%showed no cytotoxicity to MG-63 osteosarcoma cells and the extracts of Zn–xTi alloys exhibited enhanced cytocompatibility with increasing Ti content. | Kun Wang Xian Tong Jixing Lin Aiping Wei Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
| 20 | Improvements in mechanical, corrosion, and biocompatibility properties of Mg–Zr–Sr–Dy alloys via extrusion for biodegradable implant applications显示文摘In this study,extrusion was performed on Mg-Zr-Sr-Dy alloys for improving their mechanical,corrosion,and biocompatibility properties.Effects of extrusion and alloying elements on the microstructural characteristics,tensile and compressive strengths,corrosion behavior,and biocompatibility were investigated.The Mg-Zr-Sr-Dy alloys were composed of an α-Mg matrix containing {10■2} extension twins and secondary phases of intermetallic compounds Mg_(17)Sr_(2) and Mg_(2)Dy.Evolution of basal and rare earth(RE) textures was observed in the extruded alloys and an increase in Dy content to 2 wt.% resulted in texture randomization and strengthening of the RE component,mainly due to particle-stimulated nucleation and a change from discontinuous dynamic recrystallization to continuous dynamic recrystallization,which also led to an improved tension-compression yield asymmetry of 0.87.Extrusion of the alloys significantly enhanced their tensile and compressive properties due to improved distribution of alloying elements and formation of textures.Corrosion rates tested by hydrogen evolution testing,potentiodynamic polarization,and electrical impedance spectroscopy showed similar trends for each composition,and the lowest corrosion rate of 3.37 mmy^(-1) was observed for the Mg-1Zr-0.5Sr-1Dy in the potentiodynamic polarization testing.Dy_(2)O_(3) was observed in the inner layers of the Mg(OH)_(2) protective films,whose protective efficacy was confirmed by charge-transfer and film resistances.A comparison among the minimum CRs observed in this study and previously studied as-cast Mg-Zr-Sr-Dy and extruded Mg-Zr-Sr alloys,demonstrates that both the extrusion process and addition of Dy in Mg-Zr-Sr improved the CR.Similarly,extruded Mg-Zr-Sr-Dy alloys showed improved cell viability and adhesion of human osteoblast-like SaOS2 cells due to increased corrosion resistance and enhanced Sr distribution within the Mg matrix. | Faisal Kiani Jixing Lin Khurram Munir Cuie Wen Yuncang Li | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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