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| 1 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 2 | Uniformly dispersed FeOx atomic clusters by pulsed arc plasma deposition: An efficient electrocatalyst for improving the performance of Li-O2 battery显示文摘现在的学习探索了一个新方法改进非宝贵的金属的催化活动,特别在电气化学的反应。弧分泌物生产的高度电离的 Fe 血浆一致地在多孔的碳底层上被扔并且在碳表面上形成了原子簇。同样准备的 FeO x /C 材料在不同的当前的率下面在一节可充电的 Li-O 2 电池作为阴极材料被测试。结果以周期生活和反应率在电池性能显示出重要改进。而且, X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 结果证明同样准备的阴极材料稳定了阴极并且减少了方面反应并且当前的率是在分泌物产品的成核的一个关键因素。 | Xiangyi Luo Jun Lu Evan Sohm Lu Ma Tianpin Wu Jianguo Wen Dantong Qiu YunKai Xu Yang Ren Dean J. Miller Khalil Amine | 2016 | Nano Research2016，9，7： | 3 |
| 3 | Motion compensation for high-resolution automobile FMCW SAR显示文摘 | WANG Robert LUO Yunhua DENG Yunkai | 2013 | IEEE Gieoscience and Remote sensing Letter2013，10，5： | 1 |
| 4 | Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota显示文摘Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain uncertain.Herein,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate underlyingmechanisms.In female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose level.The only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,6-DCCZ.We also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic disorders.Our findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic activities.Overall,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms. | Chenyang Ji Yunkai Luo Jiawen Yang Yaoyao Dai Jiahui Miao Siqing Yue Meirong Zhao | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 5 | CORRECTION:Author Correction:Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘In the initial published version of this article,there were errors in the 5th and 6th affiliations.The correct 5th affiliation is“State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Beijing,China”. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，6： | 0 |
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