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| 1 | FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway). | Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang | 2020 | Molecular Plant2020，13，3： | 8 |
| 2 | Integrin β4 was downregulated on the airway epithelia of asthma patients显示文摘流上皮的功能的动态平衡的上皮的房间和损失是的航线气喘的主要病理学的特征;然而,位于这些病理下面的机制仍然保持阴暗。我们的以前的工作证明在 integrin 的 5 flanking 区域有三个变化地点 4 在气喘病人,它与 integrin 的减少的表示被相关 4 在外部白血球。Integrin 4 是航线 epithelia 上的一个重要结构的粘附分子保留上皮的房间的结构的粘附。在这个工作,我们进一步表明了 4 表示是的那 integrin 在气喘病人的航线 epithelia 的 downregulated。探查在 integrin 的 imbalanced 表示之间的关系 4 并且航线的机能障碍在气喘的上皮的房间, integrin 4 由 integrin 是在人的支气管的上皮房间(16HBE14O ) 的 silenced 4 小介入的 RNA lentivirus 向量。在 integrin 的 silencing 之上 4, 16HBE14O 房间显示出减少的增长和创伤修理。大多数房间被显示在 integrin 以后在 G1 阶段被逮捕 4 silencing,和增加的 apoptosis 在 integrin 4 沉默房间被导致。在摘要,我们的结果提供了引人注目的证据那 integrin 4 涉及结构的正直和航线的功能的动态平衡上皮的房间。它是可能的 4 在气喘航线 epithelia 上贡献的 integrin 的那 downregulation 航线的结构的混乱和机能障碍上皮的房间。 | Chi Liu Yang Xiang Huijun Liu Yun Li Yurong Tan Xiaolin Zhu DanZeng Menglan Li Liwen Zhang Xiaoqun Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 3 | FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma显示文摘Background:Non-small cell lung cancer(NSCLC)has a poor prognosis with a low 5-year survival rate.Lung adenocarcinoma(LUAD)accounts for 50%.Facio-genital dysplasia-5(FGD5),a member of a subfamily of Rho GTPGDP exchange factors,may be a good molecular biomarker for diagnosis and prognosis.Objective:To explore the clinical application of FGD5,the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients.Methods:Through the Wilcoxon signed-rank test and logistic regression,the correlation between clinical characteristics and FGD5 expression was analyzed.Kaplan-Meier plotter analysis,Cox regression,and a receiver operating characteristic(ROC)curve were constructed to evaluate the influence of FGD5 on prognosis.The function of FGD5 in lung cancer was analyzed using Gene set enrichment analysis(GSEA)and Single Sample Gene Set Enrichment Analysis(ssGSEA).Results:Compared to normal tissues,FGD5 was downregulated in LUAD.FGD5 may be a potential diagnostic and prognostic biomarker of lung cancer for its association with improved overall survival(OS),progression-free interval(PFI),and disease-specific survival(DSS)in LUAD.Results of functional analysis suggested that FGD5 was involved in the immune response for its association with immune infiltration.Conclusion:FGD5 may be a significant molecular biomarker for diagnosis and prognosis,presenting as an independent prognostic risk factor for LUAD. | ZHONGXIANG TANG LILI WANG GUOJUN WU LING QIN YURONG TAN | 2023 | BIOCELL2023，47，11： | 0 |
| 4 | Secure routing and transmission scheme for space-ocean broadband wireless network显示文摘Dear editor,Increase in maritime activities with exclusive economic zones leads to an increase in demands for information security in maritime communication networks.In maritime,all ships must install an automatic identification system(AIS)to ensure navigational safety,including eavesdropper ships(ESs).Therefore,the navigation information of the ships is easy for an operator to obtain via the AIS.In the study of[1],the author proposed a new AIS-based ad hoc network model and an AISbased ad hoc routing protocol for ship-to-ship and ship-to-shore data communications.To enhance the secrecy of wireless communications,physical layer security(PLS)uses the characteristics of wireless channels[2].A relay-aided PLS is suited for maritime networks.In[3],fountain code and relay-aided PLS techniques were found to be suitable for wireless networks.In[4],the PLS in opportunistic relay selection networks over independent and identically distributed Rayleigh fading channels was studied. | Yuzhou FU Chuan-Ao JIANG Yurong QIN Liuguo YIN | 2020 | Science China(Information Sciences)2020，63，4： | 0 |
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