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| 1 | MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1显示文摘Interferon(IFN)-mediated pathways are a crucial part of the cellular response against viral infection.Type III IFNs,which include IFN-λ1,2 and 3,mediate antiviral responses similar to Type I IFNs via a distinct receptor complex.IFN-λ1 is more effective than the other two members.Transcription of IFN-λ1 requires activation of IRF3/7 and nuclear factor-kappa B(NF-κB),similar to the transcriptional mechanism of Type I IFNs.Using reporter assays,we discovered that viral infection in-duced both IFN-λ1 promoter activity and that of the 3′-untranslated region(UTR),indicating that IFN-λ1 expression is also regulated at the post-transcriptional level.After analysis with microRNA(miRNA)prediction programs and 3′UTR targeting site assays,the miR-NA-548 family,including miR-548b-5p,miR-548c-5p,miR-548i,miR-548j,and miR-548n,was identified to target the 3′UTR of IFN-λ1.Further study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-λ1.In contrast,their inhibitors,the complemen-tary RNAs,enhanced the expression of IFN-λ1 and IFN-stimulated genes.Furthermore,miRNA-548 mimics promoted infection by enterovirus-71(EV71)and ve-sicular stomatitis virus(VSV),whereas their inhibitors significantly suppressed the replication of EV71 and VSV.Endogenous miRNA-548 levels were suppressed during viral infection.In conclusion,our results sug-gest that miRNA-548 regulates host antiviral response via direct targeting of IFN-λ1,which may offer a poten-tial candidate for antiviral therapy. | Yongkui Li Jiajia Xie Xiupeng Xu Jun Wang Fang Ao Yushun Wan Ying Zhu | 2013 | Protein & Cell2013，4，2： | 22 |
| 2 | The development of China's Yangtze River Economic Belt:how to make it in a green way?显示文摘The Yangtze River is one of the largest and longest rivers in Asia.The river originates in the Tibet-Qinghai Plateau(headwater reach),passes through the mountainous provinces of Sichuan,Yunnan and Chongqing(upper reach),flows into the Central Plain(middle reach)and Lower Plain(lower reach),and finally empties into the East China Sea in Shanghai(estuary).The Yangtze River Economic Belt(YREB;Fig.1)has a surface area of 2.1 | Yushun Chen Shuanghu Zhang Desheng Huang Bai-Lian Li Junguo Liu Wenjin Liu Jing Ma Fang Wang Yong Wang Shengjun Wu Yegang Wu Jinyue Yan Chuanbo Guo Wei Xin Hao Wang | 2017 | Science Bulletin2017，62，9： | 20 |
| 3 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 4 | Timing Constraint Workflow Nets for Workfiow Analysis 显示文摘 | Li Jianqiang Fan Yushun Zhou Mengchu | 2003 | IEEE Transactions on Systems Man and Cybernetics part A: Systems and Humans (S1083-4427)2003，33，2： | 1 |
| 5 | Timing constraint workflow nets for workflow analysis显示文摘 | LI Jianqiang FAN Yushun ZHOU Mengehu | 2003 | IEEE Transactions on Systems Man and Cybernetics Part A2003，33，2： | 1 |
| 6 | Performance modeling and analysis of workflow显示文摘 | LI Jianqiang FAN Yushun ZHOU Mengchu | 2004 | IEEE Transactions on Systems Man and Cybernetics Part A2004，34，2： | 1 |
| 7 | Effect of anti-freezing admixtures on alkali-silica reaction in mortars显示文摘 | Liu Junzhe Li Yushun Lv Lihua | 2005 | Journal of Wuhan University of Technology - Mater Sci Ed2005，，2： | 1 |
| 8 | Performance modeling and analysis of workflow显示文摘 | LI Jianqiang FAN Yushun ZHOU Mengchu | 2004 | IEEE Transactions on Systens Man and Cybernetics2004，34，2： | 1 |
| 9 | Timing constrain workflow nets for workflow analysis 显示文摘 | YuShun Fan MengChu Zhou | 2003 | IEEE Transaction on System Man and Cybernetics-Part A: System and Humans2003，33，2： | 1 |
| 10 | Performance modeling and analysis of workflow显示文摘 | LI Jianqiang FAN Yushun ZHOU Mengchu | 2004 | IEEE Transactions on Systems Man and Cybernetics Part A: Systems and Humans2004，34，2： | 1 |
| 11 | Timing constraint workflow nets for workflow analysis显示文摘 | Li Jianqiang Fan Yushun Zhou Mengchu | | 0，，： | 1 |
| 12 | A SIXTH ORDER AVERAGED VECTOR FIELD METHOD显示文摘在这份报纸,基于生根的树和 B 系列的理论,我们为顺序 = 的树建议替换法律的具体公式 5。在新替换法律的帮助下,我们导出扩大平均向量地(AVF ) 方法让一般 Hamiltonian 系统更高订的一个 B 系列综合者。新综合者结果是六的顺序并且确切为 Hamiltonian 系统保存精力。数字实验被介绍表明精确性和第六个顺序 AVF 方法的保存精力的性质。[从作者抽象] | Haochen Li Yushun Wang Mengzhao Qin | 2016 | Journal of Computational Mathematics2016，34，5： | 1 |
| 13 | Effect of anti-freezing admixtures on alkali-silica reaction in mortars 显示文摘 | Liu Junzhe Li Yushun Lv Lihua | 2005 | Wuhan university of Technology-Mater Sei Ed2005，2，： | 1 |
| 14 | Bending Resistance of I-Section Bamboo-Steel Composite Beams Utilizing Adhesive Bonding显示文摘 | Li Yushun Shan Wei Shen Huangying | 2015 | Thin-Walled Structures2015，89，： | 1 |
| 15 | Performance modeling and analysis of workflow显示文摘 | LI Jianqiang FAN Yushun ZHOU Mengchu | 2004 | IEEE Transaction on Systems Man and Cybernetics2004，34，2： | 1 |
| 16 | Flexural behavior of lightweight bamboo–steel composite slabs显示文摘 | Yushun Li Huangying Shen Wei Shan Tianshi Han | 2012 | Thin-Walled Structures2012，，： | 1 |
| 17 | Water extract of the fungi from Fuzhuan brick tea improves the beneficial function on inhibiting fat deposition显示文摘 | Yuxuan Peng Zhe Xiong Juan Li Jian-an Huang Cuiqin Teng Yushun Gong Zhonghua Liu | 2014 | International Journal of Food Sciences and Nutrition2014，，5： | 1 |
| 18 | Performance Modeling and Analysis of Workflow显示文摘 | Li J ianqiang Fan Yushun Zhou Mengchu | 2005 | IEEE Transactions on Sys terns Man and Cybernetics2005，34，2： | 1 |
| 19 | 3D Printing of Nacre-Inspired Structures with Exceptional Mechanical and Flame-Retardant Properties显示文摘Flame-retardant and thermal management structures have attracted great attention duc to the requirement of high-temperature exposure in industrial,aerospace,and thermal power fields,but the development of protoctive fire-retardant structures with complex shapes to fit arbitrary surfaces is still challenging.Herein,we reported a rotation-blade casting-assisted 3D printing process to fabricate nacre-inspired structures with exceptional mechanical and flame-retardant properties,and the relatedi fundamental mechanisms are studied.3-(Trimethoxysilyl)propyl methacrylate(TMSPMA)modified boron nitride nanoplatelets(BNs)were aligned by rotation-blade casting during the 3D printing process to build the'hrick and mortar'architecture.The 3D printed structures are more lightweight,while having higher fracture toughness than the natural nacre,which is attributed to the crack deflection,aligned BN(a-BNs)bridging,and pull-outs reinforced structures by the covalent bonding between TMSPMA grafted a-BNs and polymer matrix.Thermal conductivity is enhanced by 25.5 times compared with pure polymer and 5.8 times of anisotropy due to the interconnection of a-BNs.3D printed heat-exchange structures with vertically aligned BNs in complex shapes were demonstrated for efficient thermal control of high-power light-emitting diocles.3D printed helmet and armor with a-BNs show exceptional mechanical and fire-retardant properties,demonstrating integrated mechanical and thermal protection. | Yang Yang Ziyu Wang Qingqing He Xiangjia Li Gengxi Lu Laiming Jjiang Yushun Zeng Brandon Bethers Jie Jin Shuang Lin Siqi Xiao Yizhen Zhu Xianke Wu Wenwu Xu Qiming Wang Yong Chen | 2022 | Research2022，，2： | 1 |
| 20 | Fabrication of Super-Hydrophobic Surfaces with Long-Term Stability显示文摘 | Yushun Zhao Jian Li Jianlin Hu Lichun Shu Xianming Shi | 2011 | Journal of Dispersion Science and Technology2011，，7： | 1 |
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