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| 1 | Design,synthesis,and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation显示文摘Bcr-Abl threonine 315 to isoleucine 315(T315 I)gatekeeper mutation induced drug resistance remains an unmet clinical challenge for the treatment of chronic myeloid leukemia(CML).Chemical degradation of Bcr-AblT315 Iprotein has become a potential strategy to overcome drug resistance.Herein,we first described the design,synthesis,and evaluation of a new class of selective Bcr-AblT315 I proteolysis-targeting chimeric(PROTAC)degraders based on GZD824(reported as Bcr-AblT315 Iinhibitor by our group).One of the degrader 7 o with 6-member carbon chain linkage with pomalidomide exhibits the most potent degradation efficacy with DR of 69.89%and 94.23%at 100 and 300 nmol/L,respectively,and has an IC50 value of 26.8±9.7 nmol/L against Ba/F3T315 Icells.Further,7 o also displays substantial tumor regression against Ba/F3-Bcr-AblT315 Ixenograft model in vivo. | Liang Jiang Yuting Wang Qian Li Zhengchao Tu Sihua Zhu Sanfang Tu Zhang Zhang Ke Ding Xiaoyun Lu | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 2 | Catalytic wet air oxidation of 2-chlorophenol over sewage sludge derived carbon-based catalysts 显示文摘 | TU Yuting XIONG Ya TIAN Shuanghong | 2014 | Journal of Hazardous Materials2014，276，： | 1 |
| 3 | Analysis of the Financing Mode of Small and Medium-Sized Enterprises Under the DC/EP Platform Based on a Comparison with the Traditional Bank Financing Mode显示文摘As a legal currency with the credit endorsement of the Chinese government,DC/EP has many advantages and special characteristics.Based on the application of DC/EP in the financing of small-and medium-sized enterprises(SMEs),this paper studies the optimal financing decisions of SMEs under both the traditional financing mode and the DC/EP financing mode.Considering the construction and use costs of DC/EP and the role of DC/EP credit traceability in improving mortgage rates,this paper explores the feasible range for SMEs to select DC/EP financing.It is found that mortgage rates affect the returns of SMEs when they take on loans;under different credit strategies,the pledge rate set by the bank will affect the financing willingness of SMEs.The participants had different optimal mortgage rates to optimize the returns of borrowers and banks.High-quality SMEs are more willing to use the DC/EP platform for financing.With the increase in default costs,banks will be more inclined to use DC/EP,while enterprises will be inclined to utilize the traditional financing mode.Through the comparative analysis of the two financing modes,the default cost range that neither banks nor borrowers are willing to use DC/EP is found.This study provides theoretical support and management inspiration for scientific decision-making to solve the financing problems of SMEs by using DC/EP. | Yuting TU Huan WANG Xin YAN Yongwu LI | 2023 | Journal of Systems Science and Information2023，11，1： | 0 |
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