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您的检索式：作者名="Yuval Rinkevich"
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| 1 | Converting fibroblastic fates leads to wound healing without scar显示文摘In a recent paper published in Science,Mascharak et al.^(1) demonstrated that inhibiting Engrailed-1 activation in wound fibroblasts promotes scarless wound repair that phenocopies wound repair by regeneration seen in lower taxon groups and rarely in mammals.Many living species of chordates,including vertebrates,respond to injury by regenerating a perfect tissue replica.Mammals and humans on the other hand,with some rare exceptions,replaced true regeneration with scar tissue build-up in wounds. | Dongsheng Jiang Yuval Rinkevich | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 2 | Immunomodulatory Nanosystems:Advanced Delivery Tools for Treating Chronic Wounds显示文摘The increasingly aging society led to a rise in the prevalence of chronic wounds(CWs),posing a significant burden to public health on a global scale.One of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive(hyper)inflammation.A variety of immunomodulatory therapies have been proposed to address this condition.Yet,to date,current delivery systems for immunomodulatory therapy remain inadequate and lack efficiency.This highlights the need for new therapeutic delivery systems,such as nanosystems,to manage the pathological inflammatory imbalance and,ultimately,improve the treatment outcomes of CWs.While a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects,the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively scarce.Therefore,this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs,discuss important advancements in our understanding of CW healing,and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of CWs.In addition,we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field. | Xiangyu Chu Yuan Xiong Samuel Knoedler Li Lu Adriana CPanayi Michael Alfertshofe Dongsheng Jiang Yuval Rinkevich Ze Lin Zhiming Zhao Guandong Daia Bobin Mi Guohui Liu | 2023 | Research2023，，4： | 0 |
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