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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Standardization and modularization driven by inimizing overall process effort显示文摘 | Yuval S Yoram R | 2006 | Computer-Aided Desin2006，38，5： | 1 |
| 3 | Disrup- tion of Napl4, a plastid - localized non-intrin- sic ABC protein in krabidopsis thaliana results in the over-accumulation of transition metals and in aberrant chloroplast structures 显示文摘 | Shimoni S E Hassidim M Yuval N N | 2010 | Plant Cell&Environment2010，33，6： | 1 |
| 4 | Cumulative exposure to particulate matter air pollution and long-term post-myo-cardial infarction outcomes显示文摘 | Koton S Molshatzki N Yuval | 2013 | Prev Med2013，57，4： | 1 |
| 5 | Representation of change in controlled medical terminologies显示文摘 | Diane E O Yuval S Edward H | 1999 | Artificial Intelligence in Medicine1999，15，1： | 1 |
| 6 | The relationships between endometrial thickness, and blood flow and pregnancy rates in in-vitro fertilization 显示文摘 | Yuval Y Lipitz S Dor J | 1999 | Hu man Reproduction1999，14，4： | 1 |
| 7 | Cumulative exposure to particulate matter air pollution and long-term post-myocardial infarction outcomes 显示文摘 | Koton S Molshatzki N Yuval | 2013 | Preventive Medicine2013，57，： | 1 |
| 8 | Recent progress in the development of plasma-filled traveling-wave tubes and backward-wave oscillators显示文摘 | GREGORY S NUSINOVICH YUVAL CARMEL THOMAS M ANTONSEN | 1998 | IEEE Transactions on Plasma Science1998，26，3： | 1 |
| 9 | Detection of malicious code by applying machine learning classifiers on static features:a state-of-the-art survey显示文摘 | Asaf S Robert M Yuval E | | 0，，1： | 1 |
| 10 | Recent Progress in the Development of Plasma-Filled Traveling-wave Tubes and Backward-Wave Oscillators显示文摘 | Gregory S Nusinovich Yuval Carmel | 1998 | IEEE Transactions on Plasma Science1998，26，3： | 1 |
| 11 | Microbial Hemicellulases 显示文摘 | Dalia S Yuval S | 2003 | Current Opinion in Microbiology2003，6，3： | 1 |
| 12 | Recent Progress in Development of PlasmasFilled Traveling-Wave Tubes and Backward-Wave Oscillators显示文摘 | Nusinovich Gregory S Carmel Yuval Antonsen Thomas M | | 0，，03： | 1 |
| 13 | Standardization and modulariza- tion driven by minimizing overall process effort显示文摘 | Yuval S Yoram R | 2006 | Computer-Aided Design2006，38，5： | 1 |
| 14 | The relationships between endometrial thickness,and blood flow and pregnancy rates in in - vitro fertilization 显示文摘 | Yuval Y Lipitz S Dot J | 1999 | Hum Reprod1999，14，4： | 1 |
| 15 | Recent Progress in the Deve lopment of Plasma-Filled Traveling-wave Tubes and Backward-Wave Oscillators显示文摘 | Gregory S Nusinovich Yuval Carmel Thomas M Antonsen | 1998 | IEEE Transactions on Plasma Science1998，26，3： | 1 |
| 16 | QSIA-a Web-based environment for learning,assessing and knowledge sharing in communities显示文摘 | Rafaeli S Barak M Yuval D G | 2004 | Computers & Education2004，43，3： | 1 |
| 17 | The relationship between endome- trial thickness, and blood flow and pregnancy rates in invitro fertili- zation显示文摘 | Yuval Y Lipitz S Dot J | 1999 | Human Reprod1999，14，4： | 1 |
| 18 | Electromagnetic properties of periodic cavities coupled to a radiating antenna显示文摘 | Kobayashi S Botton M Yuval C | 1998 | IEEE Trans Plasma Sci1998，26，3： | 1 |
| 19 | Molecular and cellular biomarkers for angiogenesis in clinical ontology 显示文摘 | FRANCESCO B PATRIZIA M YUVAL S | 2007 | Drug Discovery Today2007，12，1920： | 1 |
| 20 | Microbial hemicellulases显示文摘 | Dalia S Yuval S | 2003 | Current Opinion in Microbiology2003，6，3： | 1 |
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