|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine显示文摘Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development. | Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao | 2023 | hLife2023，1，1： | 0 |
| 2 | Surgical treatment effects in cancer of the cardia and esophagogastric junction显示文摘Objective: To evaluate the treatment effects of total gastrectomy (TG) and proximal gastrectomy (PG) for cancer of the cardia and esophagogastric junction. Methods: forty-five patients with cancer of the cardia and esophagogastric junc- tion underwent surgical resection. Of them, 29 were treated using proximal gastrectomy and 16 total gastrectomy. The 3-year and 5-year survival rate and the postoperative complication rate and mortality rate were followed up and compared between the two groups. Results: The 3-year and 5-year survival rates of group PG were 44.8% and 20.7%, of group TG were 37.5% and 18.8%, respectively, and the differences were not statistically significant (χ2 = 3.84, P > 0.05; χ2 = 3.89, P > 0.05). The postoperative complication and mortality rate of group PG were 13.7% and 6.8%, of group TG was all 6%, respectively. Conclusion: Proximal and total gastrectomy treatment effects can not significantly influence the prognosis of patients in progressive stage of cancer of cardia and esophagogastric junction. | Yumin Zhou Jiong Pan Yuwei Sheng Hao Liu Ziping Fan | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 3 | Dynamics and biological relevance of epigenetic N^(6)-methyladenine DNA modification in eukaryotic cells显示文摘DNA methylation represents a major type of DNA modifications that play key roles in diverse biological processes.With the recent development of highly selective and sensitive bioanalytical techniques,N^(6)-methyladenine(6mA)has been characterized as an important internal DNA modification dynamically occurring in multiple eukaryotes including humans.Increasing evidence has indicated that 6mA may act as a novel epigenetic modification involved in regulation of development,stress response and diseases such as cancer and neurodegenerative disorders.We review herein the recent advances in the detection and functional studies of 6mA modification,with special emphasis on its biological consequences and human health relevance as well as its dynamic regulation by various types of methyltransferases,demethylases and 6mA-binding proteins.It can be envisaged that further chemical and biological studies of 6mA modification will lead to a better understanding about its potentially important roles in normal and pathological biological processes. | Yuwei Sheng Meijuan Zhou Changjun You Xiaoxia Dai | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 4 | Next-generation sequencing-based analysis of the effect of N^(6)-methyldeoxyadenosine modification on DNA replication in human cells显示文摘N^(6)-methyldeoxyadenosine(6 mdA) modification is considered as a new epigenetic mark that may play important roles in various biological processes.However,it remains unclear about the effect of 6 mdA on DNA replication in human cells.Herein,we combined next-generation sequencing with shuttle vector technology to explore how 6 mdA affects the efficiency and accuracy of DNA replication in human cells.Our results showed that 6 mdA neither blocked DNA replication nor induced mutations in human cells.Moreover,we found that the depletion of translesion synthesis DNA polymerase(Pol) κ,Pol η,Pol ι or Pol ζ did not significantly change the biological consequences of 6 mdA during replication in human cells.The negligible impact of 6 mdA on DNA replication is consistent with its potential role in epigenetic gene expression. | Juan Wang Yuwei Sheng Ying Yang Xiaoxia Dai Changjun You | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 5 | Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines显示文摘Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2(VMAT2)into synaptic vesicles for storage and subsequent release in neurons.Impaired VMAT2 function underlies various neuropsychiatric diseases.VMAT2 inhibitors reserpine and tetrabenazine are used to treat hypertension,movement disorders associated with Huntington’s Disease and Tardive Dyskinesia.Despite its physiological and pharmacological significance,the structural basis underlying VMAT2 substrate recognition and its inhibition by various inhibitors remains unknown.Here we present cryo-EM structures of human apo VMAT2 in addition to states bound to serotonin,tetrabenazine,and reserpine.These structures collectively capture three states,namely the lumen-facing,occluded,and cytosol-facing conformations.Notably,tetrabenazine induces a substantial rearrangement of TM2 and TM7,extending beyond the typical rocker-switch movement.These functionally dynamic snapshots,complemented by biochemical analysis,unveil the essential components responsible for ligand recognition,elucidate the proton-driven exchange cycle,and provide a framework to design improved pharmaceutics targeting VMAT2. | Yuwei Wang Pei Zhang Yulin Chao Zhini Zhu Chuanhui Yang Zixuan Zhou Yaohui Li Yonghui Long Yuehua Liu Dianfan Li Sheng Wang Qianhui Qu | 2024 | Cell Research2024，34，1： | 0 |
| 6 | Unraveling the Effect of Cation Types on Electrochromic Properties of Titanium Dioxide Nanocrystals显示文摘Electrochromic(EC)devices have been regarded as promising candidates for energy-saving smart windows,next-generation displays,and wearable electronics.Monovalent ions such as H^(+)-and Li^(+)-based electrolytes are the benchmark insertion ions for EC devices but have serious limitations such as high cost,instability,and difficulty to handle.Seeking multivalent electrolytes is an effective alternative way to prepare high-performance EC devices;unfortunately,the related reports are currently limited to tungsten oxide EC materials.Herein,for the first time,we investigate the EC properties driven by different valence cationic(i.e.,Li^(+),Zn^(2+),and Al^(3+))electrolytes in the titanium dioxide system.It is found that the initial optical modulation ranges of TiO_(2)nanocrystal(NC)films in Li^(+),Zn^(2+),and Al^(3+)electrolytes are 76.8%,77.4%,and 77.3%,respectively.After 250 cycles,the optical contrast of these films in Zn^(2+)electrolyte decreased by only 2.3%,much lower than that in benchmark Li^(+)electrolyte of 10.1%and Al^(3+)electrolyte of 59.1%.Density functional theory calculation indicates that the potential barriers of Li^(+),Zn^(2+),and Al^(3+)in TiO_(2)are 0.59,0.55,and 0.74 eV,respectively,which makes TiO_(2)NCs show good EC properties in Zn^(2+)electrolytes.This work unravels the effect of different valence cations on the electrochromic properties of titanium dioxide NCs,which may provide some new directions for the development of excellent EC devices with long-term stability and durability. | Yi Liang Sheng Cao Yuwei Liu Lijuan He Xinxin Han Ruosheng Zeng Jialong Zhao Bingsuo Zou | 2022 | Energy Material Advances2022，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员