|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma显示文摘Objective:Histology grade,subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and survival.The aim of the study was to investigate the relationship between chromosomal instability,morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma(LNMA).Methods:We developed a whole genome copy number variation(WGCNV)scoring system and applied next generation sequencing to evaluate CNVs present in 91 LNMA tumor samples.Results:Higher histological grades,aggressive subtypes and more advanced TNM staging were associated with an increased WGCNV score,particularly in CNV regions enriched for tumor suppressor genes and oncogenes.In addition,we demonstrate that 24-chromosome CNV profiling can be performed reliably from specific cell types(<100 cells)isolated by sample laser capture microdissection.Conclusions:Our findings suggest that the WGCNV scoring system we developed may have potential value as an adjunct test for predicting the prognosis of patients diagnosed with LNMA. | Zheng Wang Lin Zhang Lei He Di Cui Chenglong Liu Liangyu Yin Min Zhang Lei Jiang Yuyan Gong Wang Wu Bi Liu Xiaoyu Li David S Cram Dongge Liu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
| 2 | A discrete ar- tificial bee colony algorithm incorporating differential evolu- tion for the flowshop scheduling problem with blocking显示文摘 | HAN Yuyan GONG Dunwei SUN Xiaoyan | 2015 | Engineering Optimization2015，47，7： | 1 |
| 3 | Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer显示文摘 | Gianfranco Alpini Shannon S. Glaser Jing-Ping Zhang Heather Francis Yuyan Han Jiao Gong Allison Stokes Taylor Francis Nathan Hughart Levi Hubble Shi-Mei Zhuang Fanyin Meng | 2011 | Journal of Hepatology2011，，6： | 1 |
| 4 | Construction and analysis of a coral reef trophic network for Qilianyu Islands,Xisha Islands显示文摘Qilianyu Islands coral reefs(QICR),located in the northeastern part of the South China Sea,has been affected by human activities and natural disturbance.To characterize the trophic structure,ecosystem properties and keystone species of this region,a food-web model for the QICR is developed using methods involving a mass-balance approach with Ecopath with Ecosim software.Trophic levels range from 1.00 for detritus and primary producers to 3.80 for chondrichthyes.The mean trophic transfer efficiency for the entire ecosystem is 13.15%,with 55%of total energy flow originating from primary producers.A mixed trophic impact analysis indicates that coral strongly impacts most components of this ecosystem.A comparison of our QICR model with that for other coral reef ecosystems suggests that the QICR ecosystem is immature and/or is degraded. | Xiaofan Hong Zuozhi Chen Jun Zhang Yan’e Jiang Yuyan Gong Yancong Cai Yutao Yang | 2022 | Acta Oceanologica Sinica2022，41，12： | 0 |
| 5 | Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway显示文摘Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatment,was evaluated for its impact on CRC proliferation and migration,alongside its underlying mechanisms,through both in vitro and in vivo analyses.The study employed MTT assay,colony formation,wound healing,transwell assays,flow cytometry,and Hoechst 33342 staining to assess cell proliferation,migration,and apoptosis.Additionally,proteome microarray assay and western blotting analyses were conducted to elucidate diacerein’s specific mechanism of action.Our findings indicate that diacerein significantly inhibits DCLK1-dependent CRC growth in vitro and in vivo.Through high-throughput proteomics microarray and molecular docking studies,we identified that diacerein directly interacts with DCLK1.Mechanistically,the suppression of p-STAT3 expression following DCLK1 inhibition by diacerein or specific DCLK1 siRNA was observed.Furthermore,diacerein effectively disrupted the DCLK1/STAT3 signaling pathway and its downstream targets,including MCL-1,VEGF,and survivin,thereby inhibiting CRC progression in a mouse model,thereby inhibiting CRC progression in a mouse model. | YE Qiaobei ZHU Yu SHI Meng LV Linxi GONG Yuyan ZHANG Luyao YANG Lehe ZHAO Haiyang ZHAO Chengguang XU Huanhai | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 6 | A review of intelligent optimization for group scheduling problems in cellular manufacturing显示文摘Given that group technology can reduce the changeover time of equipment,broaden the productivity,and enhance the flexibility of manufacturing,especially cellular manufacturing,group scheduling problems(GSPs)have elicited considerable attention in the academic and industry practical literature.There are two issues to be solved in GSPs:One is how to allocate groups into the production cells in view of major setup times between groups and the other is how to schedule jobs in each group.Although a number of studies on GSPs have been published,few integrated reviews have been conducted so far on considered problems with different constraints and their optimization methods.To this end,this study hopes to shorten the gap by reviewing the development of research and analyzing these problems.All literature is classified according to the number of objective functions,number of machines,and optimization algorithms.The classical mathematical models of single-machine,permutation,and distributed flowshop GSPs based on adjacent and position-based modeling methods,respectively,are also formulated.Last but not least,outlooks are given for outspread problems and problem algorithms for future research in the fields of group scheduling. | Yuting WANG Yuyan HAN Dunwei GONG Huan LI | 2023 | Frontiers of Engineering Management2023，10，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员