| 1 | Nonvesicular trafficking of cholesterol by Aster proteins显示文摘In a recent article published in Nature Metabolism,Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane(PM)cholesterol to reach the endoplasmic reticulum(ER)in mouse liver during fasting,low-density lipoprotein(LDL)uptake,or reverse cholesterol transport(RCT).The Aster/GramD1 pathway plays a key role in maintaining hepatic and systemic cholesterol/lipid homeostasis.Cholesterol is an essential constituent of organellar membranes in mammalian cells[1]. | Dougall Norris Yvette Aw Hongyuan Yang | 2023 | Life Metabolism2023，2，2： | 0 |
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