|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-nave patients显示文摘AIM: To determine whether adding vitamin D, a potent immunomodulator, improves the hepatitis C virus (HCV) response to antiviral therapy. METHODS: Seventy-two consecutive patients with chronic HCV genotype 1 were randomized into two groups: the treatment group (n = 36, 50% male, mean age 47 ± 11 years) received Peg-α-2b interferon (1.5 μg/kg per week) plus ribavirin (1000-1200 mg/d) together with vitamin D3 (2000 IU/d, target serum level > 32 ng/mL), and the control group (n = 36, 60% male, mean age 49 ± 7 years) received identical therapy without vitamin D. HCV-RNA was assessed by realtime polymerase chain reaction (sensitivity, 10 IU/mL). The sustained virologic response (SVR) was defined as undetectable HCV-RNA at 24 wk post-treatment. RESULTS: Clinical characteristics were similar in both groups. The treatment group had a higher mean bodymass index (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P < 0.01), viral load (50% vs 42%, P < 0.01), and fibrosis score (> F2: 42% vs 19%, P < 0.001) than the controls. At week 4, 16 (44%) treated patients and 6 (17%) controls were HCV-RNA negative (P < 0.001). At week 12, 34 (94%) treated patients and 17 (48%) controls were HCV-RNA negative (P < 0.001). At 24 wk post-treatment (SVR), 31 (86%) treated patients and 15 (42%) controls were HCV-RNA negative (P < 0.001). Viral load, advanced fibrosis and vitamin D supplementation were strongly and independently associated with SVR (multivariate analysis). Adverse events were mild and typical of Peg-α-2b/ribavirin. CONCLUSION: Adding vitamin D to conventional Peg-α-2b/ribavirin therapy for treatment-na■ve patients with chronic HCV genotype 1 infection significantly improves the viral response. | Saif Abu-Mouch Zvi Fireman Jacob Jarchovsky Abdel-Rauf Zeina Nimer Assy Liver Unit | 2011 | World Journal of Gastroenterology2011，17，47： | 29 |
| 2 | CDX2 as a marker for intestinal differentiation: Its utility and limitations显示文摘CDX2 is a nuclear homeobox transcription factor that belongs to the caudalrelated family of CDX homeobox genes. The gene encoding CDX2 is a nonclustered hexapeptide located on chromosome 13q12-13. Homeobox genes play an essential role in the control of normal embryonic development. CDX2 is crucial for axial patterning of the alimentary tract during embryonic development and is involved in the processes of intestinal cell proliferation, differentiation, adhesion, and apoptosis. It is considered specif ic for enterocytes and has been used for the diagnosis of primary and metastatic colorectal adenocarcinoma. CDX2 expression has been reported to be organ specif ic and is normally expressed throughout embryonic and postnatal life within the nuclei of epithelial cells of the alimentary tract from the proximal duodenum to the distal rectum. In this review, the authors elaborate on the diagnostic utility of CDX2 in gastrointestinal tumors and other neoplasms with intestinal differentiation. Limitations with its use as the sole predictor of a gastrointestinal origin of metastatic carcinomas are also discussed. | Reda S Saad Zeina Ghorab Mahmoud A Khalifa | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 11 |
| 3 | Cytotoxic effects of antimicrobial photodynamic therapy on keratinocytes in vitro 显示文摘 | Zeina B Greenman J Corry D | 2002 | Br J Dermatol2002，146，4： | 1 |
| 4 | Myocardial bridge: evaluation on MDCT 显示文摘 | Zeina AR Odeh M Blinder J | 2007 | AJR2007，188，4： | 1 |
| 5 | Personalized interfaces for a Semantic Web Portal:tourism information search显示文摘 | ZEINA JRAD MARIE-AUDE AUFAURE | | 0，，： | 1 |
| 6 | Intravitreal Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration: A One-year Prospective Study显示文摘 | Ziad F. Bashshur Zeina A. Haddad Alexandre Schakal Rola F. Jaafar Marc Saab Baha’ N. Noureddin | 2008 | American Journal of Ophthalmology2008，，2： | 1 |
| 7 | Myocardial bridge: e- valuation on MDCT显示文摘 | ZEINA A R ODEH M BLINDER J | 2007 | AJR Am J Roentqenol2007，188，4： | 1 |
| 8 | Myocardial bridge:evaluation on MDCT显示文摘 | Zeina AR Odeh M Blinder J | 2007 | AJR Am J Roentgenol2007，188，4： | 1 |
| 9 | Myocardial bridge: evalua- tion on MDCT 显示文摘 | Zeina AR Odeh M Blinder J | 2007 | AJR Am J Roentgenol2007，188，4： | 1 |
| 10 | Cytotoxic effects ofantimicrobial photodynamic therapy on keratinocytes in vitro显示文摘 | Zeina B Greenman J Corry D | 2002 | Br J Dermatol2002，46，4： | 1 |
| 11 | Antibiotic use in acute cholecystiffs:practice patterns in the absence of evidence-based guidelines显示文摘 | Nadine K Souha SK | 2005 | Journal of Infection2005，51，： | 1 |
| 12 | Fused deposition modeling of novel scaffold architectures for tissue engineering applications显示文摘 | ZEINA I HUTMACHER D W TAN K C | 2002 | Biomaterials2002，23，： | 1 |
| 13 | A randomized single-blind trial of whole versus split-dose polyethylene glycol-electrolyte solution for colonoscopy preparation显示文摘 | Amer M.A. El Sayed Zeina A. Kanafani Fadi H. Mourad Assaad M. Soweid Kassem A. Barada Clarisse S. Adorian Walid A. Nasreddine Ala I. Sharara | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 14 | Killing of cutaneous microbial species by photodynamic therapy显示文摘 | Zeina B Greenman J Purcell WM | 2001 | Br J Dermatol2001，144，： | 1 |
| 15 | Myoeardial Bridge:Evaluation on MDCT显示文摘 | Zeina AR OdehM Blinder J | 2007 | AJR2007，188，： | 1 |
| 16 | Myocardial bridge:evaluation on MDCT显示文摘 | Zeina AR Odeh M Blinder J | 2007 | AJR2007，188，4： | 1 |
| 17 | Myocardial bridge : evaluation on MDCT显示文摘 | Zeina AR Odeh M Blinder J | 2007 | Am J Roentgeno12007，188，4： | 1 |
| 18 | Myocardial Bridge: Evaluation on MDCT显示文摘 | Zeina A Odeh M Blinder J | 2007 | AJR2007，88，4： | 1 |
| 19 | Fused deposition modeling of novel scaffold architectures for tissue engineering applications显示文摘 | Zeina I Hutmacherb DW | 2002 | Biomaterials2002，23，： | 1 |
| 20 | Cytotoxic effects of antimicrobialphotodynamic therapy on keratinocytes in vitro 显示文摘 | Zeina B Greenman J Cony D | 2002 | Br J Dermatol2002，146，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员