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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 3 | Seed coat microsculpturing changes during seed development in diploid and amphidipoid Brassic species显示文摘 | ZENG C L WANG J B LIU A H | 2004 | Annals of Botany2004，93，： | 1 |
| 4 | More active PtRu/C catalyst for methanol electrooxidation by reversal of mixing sequence in catalyst preparation 显示文摘 | ZENG J H LEE J Y | 2007 | Materials Chemistry and Physics2007，104，： | 1 |
| 5 | Electroless Ni-P coating of cenospheres using silver nitrate activator 显示文摘 | Zeng A X Xiong W H Xu J | 2005 | Surface&Coatings Technology2005，197，23： | 1 |
| 6 | Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold显示文摘 | Guo J Su H Zeng Y | 2007 | Nanomedicine2007，3，4： | 1 |
| 7 | Micellar-enhanced ultrafiltration of cadmiam ions with aniomc-nonionic surfactants显示文摘 | Fang Y Y Zeng G M Huang J H et a1 | 2008 | Journal of Membrane Science2008，320，12： | 1 |
| 8 | A new class of folding oligomers: crescent oligoamides显示文摘 | Zhu J Parra R D Zeng H | 2000 | J Am Chem Soc2000，122，： | 1 |
| 9 | Preparation of nickel nanopowders in ethanol-water system(EMS)显示文摘 | Zheng H G Liang J H Zeng J H | 2001 | Mater Res Bull2001，36，： | 1 |
| 10 | The effect of TLR4/7 on the TGF-β-indueed Smad signal transduction pathway in human ke- loid显示文摘 | Chen J Zeng B Yao H | 2013 | Bums2013，39，3： | 1 |
| 11 | Removal of elemental mercury from coal combustion flue gas by chloride-impregnated activa- ted carbon显示文摘 | Zeng H C Jin F Guo J | 2004 | Fuel2004，83，1： | 1 |
| 12 | Amyloid- β peptide en- hances tumor necrosis factor-a-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes显示文摘 | ZENG C LEE T J CHEN H | 2005 | J Neurochem2005，94，： | 1 |
| 13 | Development and evaluation of loopmediated isothermal amplification (LAMP) for the rapid diagnosis of Penicillium marneffei in archived tissue samples 显示文摘 | Sun J Li X Zeng H | 2010 | FEMS Immunol Med Microbiol2010，58，3： | 1 |
| 14 | Biological evaluation of novel selenazole - based compounds as potential thioredoxin reductase inhibitors 显示文摘 | Li D D He J Zeng H H | 2012 | Ap- plied Organometallic Chemistry2012，26，11： | 1 |
| 15 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 16 | Enhancement of the light output power of InGaN/GaN lightemitting diodes grown on pyramidal patterned sapphire substrates in the micro-and nanoscale显示文摘 | Gao H Y Yan F W Zhang Y Li J M Zeng Y P Wang G H | | 0，，01： | 1 |
| 17 | Ultrasonic-assisted ac etching of aluminum foils for electrolytic capacitor electrodes with enhanced capacitance显示文摘 | HOU ZH H ZENG J H CHEN J J | | 0，，： | 1 |
| 18 | Study of W/HZSM-5-based catalysts for dehydro-aromatization of CH4 in absence of 02 (11):Action of promoters Zn and Li 显示文摘 | Xiong Z T Zhang H B Lin G D Zeng J L | 2001 | Catalysis Letters2001，74，34： | 1 |
| 19 | Remote Control Stepper Motor Based on the GPRS显示文摘 | Li H X Zeng J H | 2014 | Applied Mechanics& Materials2014，，： | 1 |
| 20 | Effects of dewatering on the pyrolysis and gasification reactivity of victorian brown coal显示文摘 | ZENG C CLAYTON S WU H HAYASHI J LI C | 2007 | Energy Fuels2007，21，2： | 1 |
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