|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy of Lidan Tang on high-fat-diet induced gallstone in mice and possible mechanism显示文摘OBJECTIVE:To investigate efficacy of Lidan Tang(LDT)on gallstone induced by high fat diet in mice,and to study its underlying mechanism.METHODS:Mice were fed with high fat diet every day and treated with LDT(9.01 times of human clinic dosage).Mice were randomly divided into 6 groups as control group,gallstone model group(high-fat diet),positive control ursodeoxycholic acid(UDCA)group(80 mg·kg^-1·d^-1,i.g.),LDT low dose group(6 kg/d,i.g.),LDT middle dose group(12 kg/d,i.g.),and LDT high dose group(24 kg/d,i.g.).The whole experiment was lasted for 4 weeks.The levels of ALT,AST,LDH,CHO,HDL-C and LDL-C in serum were measured,the pathological sections were observed by hematoxylin-eosin staining,the activities of antioxidant enzymes were measured by kits,and the proteins related to oxidative stress and lipid transport were detected by Western blot analysis.RESULTS:LDT could significantly reduce the contents of ALT and AST in serum and improve the pathological tissue of liver.LDT could significantly reduce the content of MDA and LPO,and increase the level of GSH and GSH-PX in liver tissue.The data of Western blot showed that LDT had antioxidant effect promoting Keap1/Nrf2 pathway and regulated the process of lipid transport,which was statistically significant.In addition,LDT treatment inhibited the expression of ATP-binding cassette transports ABCG5/8 in liver,and reduced cholesterol transport from the hepatocytes to the gallbladder.CONCLUSION:LDT has protective effect on gallstones induced by high fat diet in mice,which might be based on the protective effect on liver,including enhancing the antioxidant capacity of liver and reducing the production of lipid peroxides. | Gao Yan Liu Caipin Li Juntong Zhai Yingying Lin Meiyu Wu Qinglin Chu Shifeng Zhang Zhao Li Jianping Zhou Xin Li Yueting Chen Naihong | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 4 |
| 2 | Comfort under personally controlled air movement in warm and humid environments显示文摘 | Yongchao Zhai Hui Zhang Yufeng Zhang Wilmer Pasut Edward Arens Qinglin Meng | 2013 | Building and Environment2013，，： | 1 |
| 3 | Multi-view radar target recognition based on multitask compressive sensing显示文摘 | LIU Shengqi ZHAN Ronghui ZHAI Qinglin | 2015 | Journal of Electromagnetic Waves and Applications2015，29，14： | 1 |
| 4 | Field measurements on microclimate in residential community in Guangzhou,China显示文摘Taking a certain housing in Guangzhou as an example,we conduct the field measurement of the microclimate at fixed points for air temperature,relative humidity,black globe temperature and wind speed,etc.We investigate the effects of manmade lake,shade of trees and ground surface character on outdoor thermal environment,and make a quantitative analysis on the weighting position of the landscape design factors in design behavior.The study intends to explore a method to improve the thermal environment of residential quarters by changing the corresponding factors. | Zhuolun CHEN Lihua ZHAO Qinglin MENG Changshan WANG Yongchao ZHAI Fei WANG | 2009 | Frontiers of Structural and Civil Engineering2009，3，4： | 0 |
| 5 | Detection of TiO and VO in the Atmosphere of WASP-121b and Evidence For its Temporal Variation显示文摘We report the transit observations of the ultra-hot Jupiter WASP-121b using the Goodman High Throughput Spectrograph at the 4 m ground-based Southern Astrophysical Research Telescope,covering the wavelength range502-900 nm.By dividing the target and reference star into 19 spectroscopic passbands and applying differential spectrophotometry,we derive spectroscopic transit light curves and fit them using a Gaussian process framework to determine transit depths for every passband.The obtained optical transmission spectrum shows a steep increased slope toward the blue wavelength,which seems to be too steep to be accounted for by Rayleigh scattering alone.We note that the transmission spectrum from this work and other works differ obviously from each other,which was pointed out previously by Wilson et al.as evidence for temporal atmospheric variation.We perform a free chemistry retrieval analysis on the optical transmission spectra from this work and the literature HST/WFC3 NIR spectrum.We determine TiO,VO and H_(2)O with abundances of-5.95_(-0.42)^(+0.47)dex,-6.72_(-1.79)^(+0.51)dex and-4.13_(-0.46)^(+0.63)dex,respectively.We compare the abundances of all three of these molecules derived from this work and previous works,and find that they are not consistent with each other,indicating the chemical compositions of the terminator region may change over long timescales.Future multi-epoch and high-precision transit observations are required to further confirm this phenomenon.We note that when combining the transmission spectra in the optical and in NIR in retrieval analysis,the abundances of V and VO,the NIR-to-optical offset and the cloud deck pressure may be coupled with each other. | Qinglin Ouyang Wei Wang Meng Zhai Guo Chen Patricio Rojo Yujuan Liu Fei Zhao Jia-Sheng Huang Gang Zhao | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员