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| 1 | Association between serum somatostatin levels and glucose-lipid metabolism in the Jino ethnic minority and Han Chinese population显示文摘We aim to investigate the relationship between serum somatostatin(SST) levels and glucose-lipid metabolism at various stages of glucose tolerance in the Jino ethnic minority(n=111) and Han population(n=113) of Yunnan Province, southwest China.Anthropometric parameters and biochemical traits were measured. Serum SST and plasma glucagon levels were tested. Participants were divided into three subgroups: isolated fasting hyperglycemia(IFH), isolated post challenge hyperglycemia(IPH)and normal glucose tolerance(NGT). SST levels were found lower while glucagon levels were significantly higher in the Jino ethnic with IPH(P=0.0026 and P=0.0069, respectively). Fasting glucose and high density lipoprotein-cholesterol(HDL-C)levels were higher(P=0.0055 and P=0.0021, respectively) and fasting insulin levels and homeostasis model assessments β-cell function were lower(P=0.0479 and P=0.0007, respectively) in the Jino population. After adjusting for confounding factors, the serum SST level was associated with glucagon(P<0.0001) in both populations. The SST level was correlated with fasting Cpeptide(P=0.0267) in Jino and HDL-C levels in Han(P=0.0079). Our findings suggest that serum SST levels and plasma glucagon levels may vary in subjects with IPH between two ethnics. | Shiyun Wang Rong Zhang Xuhong Hou Fusong Jiang Jie Wang Zhen He Feng Jiang Cheng Hu Weiping Jia | 2018 | Science China(Life Sciences)2018，61，11： | 2 |
| 2 | Enamel carbon isotope evidence of diet and habitat of Gigantopithecus blacki and associated mammalian megafauna in the Early Pleistocene of South China显示文摘Enamel stable carbon isotope analyses were conducted on the large fossil ape Gigantopithecus blacki and an associated mammalian megafauna from Longgudong Cave in Jianshi and Juyuandong Cave in Liucheng, South China. The range in δ13C values (-18.8‰ to -14.1‰) indicates that G. blacki and other large mammals fed on solely C3 biomass, and lived in forest habitats, and not open country or savannas. These results are consistent with other faunal and floral analyses for that time. The diet and habitat of G. blacki were significantly different from those of early hominins (Australopithecus and Paranthropus) from South and East Africa. Extinction of G. blacki probably was a result of forest habitat fragmentation and deterioration. | ZHAO LingXia ZHANG LiZhao ZHANG FuSong WU XinZhi | 2011 | Chinese Science Bulletin2011，56，33： | 1 |
| 3 | Protein Structure Prediction:Challenges,Advances,and the Shift of Research Paradigms显示文摘Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields,including biochemistry,medicine,physics,mathematics,and computer science.These researchers adopt various research paradigms to attack the same structure prediction problem:biochemists and physicists attempt to reveal the principles governing protein folding;mathematicians,especially statisticians,usually start from assuming a probability distribution of protein structures given a target sequence and then find the most likely structure,while computer scientists formulate protein structure prediction as an optimization problem-finding the structural conformation with the lowest energy or minimizing the difference between predicted structure and native structure.These research paradigms fall into the two statistical modeling cultures proposed by Leo Breiman,namely,data modeling and algorithmic modeling.Recently,we have also witnessed the great success of deep learning in protein structure prediction.In this review,we present a survey of the efforts for protein structure prediction.We compare the research paradigms adopted by researchers from different fields,with an emphasis on the shift of research paradigms in the era of deep learning.In short,the algorithmic modeling techniques,especially deep neural networks,have considerably improved the accuracy of protein structure prediction;however,theories interpreting the neural networks and knowledge on protein folding are still highly desired. | Bin Huang Lupeng Kong Chao Wang Fusong Ju Qi Zhang Jianwei Zhu Tiansu Gong Haicang Zhang Chungong Yu Wei-Mou Zheng Dongbo Bu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，5： | 0 |
| 4 | Triazole-gold (TAAu) catalyzed three-component coupling (A3 reaction) towards the synthesis of 2,4-disubstituted quinoline derivatives显示文摘A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy. | Fusong Zhang Qi Lai Xiaodong Shi Zhiguang Song | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
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