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| 1 | Receding horizon control for multi-UAVs close formation control based on differential evolution显示文摘Close formation flight is one of the most complicated problems on multi-uninhabited aerial vehicles (UAVs) coordinated control. Based on the nonlinear model of multi-UAVs close formation, a novel type of control strategy of using hybrid receding horizon control (RHC) and differential evolution algorithm is proposed. The issue of multi-UAVs close formation is transformed into several on-line optimization problems at a series of receding horizons, while the differential evolution algorithm is adopted to optimize control sequences at each receding horizon. Then, based on the Markov chain model, the convergence of differential evolution is proved. The working process of RHC controller is presented in detail, and the stability of close formation controller is also analyzed. Finally, three simulation experiments are performed, and the simulation results show the feasibility and validity of our proposed control algorithm. | ZHANG XiangYin, DUAN HaiBin & YU YaXiang National Key Laboratory of Science and Technology on Holistic Control, School of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, China | 2010 | Science China(Information Sciences)2010，53，2： | 22 |
| 2 | Levenberg-Marquardt based artificial physics method for mobile robot oscillation alleviation显示文摘This paper proposed a modified artificial physics(AP)method to solve the autonomous navigation problem for mobile robots in complex environments.The basic AP method tends to cause oscillations in the presence of obstacles and in narrow passages,which can result in time consumption.To alleviate oscillation,we modified the AP method using the Levenbery-Marquardt(LM)algorithm.In the modified AP method,we altered the original directions of AP forces to the Newton direction,and adjust the parameter by the LM algorithm.A series of comparative experimental results show that the modified AP method can achieve smoother trajectories with less time consumption.This demonstrates the feasibility and effectiveness of our proposed approach. | ZHANG XiangYin DUAN HaiBin LUO QiNan | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 6 |
| 3 | An efficient data compression technique based on BPDN for scattered fields from complex targets显示文摘Dear editor,For complex targets,the scattered fields vary rapidly with frequency or aspect angle owing to diverse scattering mechanisms[1].To comprehensively learn the characteristics of a target’s signature,a large number of radar cross section(RCS) | Xiangyin QUAN Bingchen ZHANG Zhengdao WANG Chao GAO Yirong WU | 2017 | Science China(Information Sciences)2017，60，10： | 5 |
| 4 | Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma显示文摘Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs(linc RNAs) play in diverse cellular processes, our knowledge of how linc RNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of linc RNAs.Consistent with previous findings of co-expression between neighboring protein-coding genes, linc RNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of linc RNAs termed 'regulatory linc RNAs', representing their dominant roles in gene regulation. The number of regulatory linc RNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory linc RNA,GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory linc RNAs with inclusion of some cancer-associated linc RNAs. Our integrated analysis reveals enhanced regulatory effects of linc RNAs and provides a resource for the study of regulatory linc RNAs that play critical roles in lung adenocarcinoma. | You Zhou Kai Wu Jianping Jiang Jinfei Huang Peiwei Zhang Yufei Zhu Guohong Hu Jingyu Lang Yufang Shi Landian Hu Tao Huang Xiangyin Kong | 2015 | Journal of Genetics and Genomics2015，42，8： | 3 |
| 5 | Resorption Efficiency of Four Cations in Different Tree Species in a Subtropical Common Garden显示文摘High rainfall in subtropical regions can leach cation elements from ecosystems,which may limit plant growth.Plants often develop efficient resorption patterns to recycle elements,but there is relatively little available information on this topic.In February 2012,a common garden was established in a subtropical forest by planting dominant trees from the area.Green and senescent leaves were sampled from 11 tree species.The concentrations of potassium(K),calcium(Ca),sodium(Na)and magnesium(Mg)were determined,and the resorption efficiencies were calculated.The results showed significant K,Na and Mg resorption in most of the investigated tree species,while Ca mainly displayed accumulation.Evergreen coniferous and evergreen broad-leaved trees(such as Cunninghamia lanceolata,Pinus massoniana,Cinnamomum camphora,and Michelia macclurei)exhibited relatively higher resorption efficiencies of K(39.0%-87.5%)and Na(18.3%-50.2%)than deciduous broad-leaved trees.Higher Mg resorption efficiencies(>50%)were detected in Liriodendron chinense,C.lanceolata and P.massoniana than in other trees.Overall,evergreen coniferous and evergreen broad-leaved trees could show higher cation resorption than deciduous broad-leaved trees.K and Mg resorption efficiencies and Ca accumulation decrease with increasing nutrient concentrations in green leaves.Our results emphasize that nutrient resorption patterns largely depend on elements and plant functions,which provides new insights into the nutrient use strategies of subtropical plants and a reference for the selection of suitable tree species in this region. | Yaoyi Zhang Xiangyin Ni Jing Yang Siyi Tan Shu Liao Dingyi Wang Kai Yue Fuzhong Wu | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 6 | Design of high performance multilayer microwave absorbers using fast Pareto genetic algorithm显示文摘The application of the Non-dominated Sorting Genetic Algorithm Ⅱ (NSGA-Ⅱ) in designing microwave absorbers is described in this paper. To obtain high performance coatings,we put forward three cost functions,which represent three objectives of strong-absorption,broad-bandwidth and thin structure,and study the tradeoffs between each other. Numerical calculations on available materials in 2―18 GHz are implemented to construct the Pareto front and Pareto-optimal surface for two and three objectives respectively. Results indicate that the NSGA-Ⅱ can work more efficiently and effectively than traditional Pareto genetic algorithms. Additionally,we present several particular designs from the above Pareto front (surface) for potential applications in different frequency bands. For example,a four-layer absorber with thickness of 2.8071 mm is obtained to provide average reflection coefficient of -11.95 dB and average reflection bandwidth of 0.5780 in 2―18 GHz,considering arbitrary incident angles (0°―89°) and both TE and TM polarizations. | JIANG LiYong LI XiangYin ZHANG Jie | 2009 | Science China(Technological Sciences)2009，52，9： | 2 |
| 7 | Effect of laser remelting on corrosion behavior of plasma-sprayed Ni-coated WC coatings显示文摘 | Xie Guozhi Zhang Jingxian Lu Yijun Wang Keyu Mo Xiangyin Lin Pinghua | 2007 | Materials Science & Engineering A2007，，： | 1 |
| 8 | Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection显示文摘Antigen detection provides particularly valuable information for medical diagnoses;however,the current detection methods are less sensitive and accurate than nucleic acid analysis.The combination of CRISPR/Cas12a and aptamers provides a new detection paradigm,but sensitive sensing and stable amplification in antigen detection remain challenging.Here,we present a PCR-free multiple trigger dsDNA tandem-based signal amplification strategy and a de novo designed dual aptamer synergistic sensing strategy.Integration of these two strategies endowed the CRISPR/Cas12a and aptamer-based method with ultra-sensitive,fast,and stable antigen detection.In a demonstration of this method,the limit of detection was at the single virus level(0.17 fM,approximately two copies/μL)in SARS-CoV-2 antigen nucleocapsid protein analysis of saliva or serum samples.The entire procedure required only 20 min.Given our system’s simplicity and modular setup,we believe that it could be adapted reasonably easily for general applications in CRISPR/Cas12a-aptamer-based detection. | Xiangxiang Zhao Zhengduo Wang Bowen Yang Zilong Li Yaojun Tong Yuhai Bi Zhenghong Li Xuekui Xia Xiangyin Chen Lixin Zhang Weishan Wang Gao-Yi Tan | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 1 |
| 9 | Design of light trapping structures for light-absorption enhancement in thin film solar cells显示文摘 | Zhang Wei Zheng Gaige Li Xiangyin | 2013 | Optik-Intemational Journal for Light and Electron Optics2013，124，16： | 1 |
| 10 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 11 | ^90Sr in Chinese tea of typical regions: activity concentration and hygienic evaluation显示文摘 | Chen Fei Yin Liangliang Kong Xiangyin Xu Ying Zhang Yao Shao Xianzhang Ji Yanqin | 2017 | 中华放射医学与防护杂志2017，37，5： | 1 |
| 12 | Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22显示文摘 | Wei Zhong Bin Cui Yizhi Zhang Haisong Jiang Shengcai Wei Lei Bu Guoping Zhao Landian Hu Xiangyin Kong | 2003 | Journal of Human Genetics2003，，7： | 1 |
| 13 | A novel image template mat- ching based on particle filtering optimization 显示文摘 | Li Hao Duan Haibin Zhang Xiangyin | 2010 | Pattern Recogni- tion Letters2010，31，13： | 1 |
| 14 | Nitrogen supply after removing the shoot apex increases the nicotine concentration and nitrogen contents in tobacco plants 显示文摘 | Xi Xiangyin Li Chunjian Zhang Fusuo | 2005 | Annals of Botany2005，96，： | 1 |
| 15 | The Influence of Self-esteem on College Students’Learning Burnout:A Mediation Model显示文摘We measured 324 college students’self-esteem,motivation for achievement,and learning burnout,and also we examined the inner mechanism of self-esteem’s influence on students’learning burnout.The results show:(1)There is a negative effect of self-esteem on college students’learning burnout;(2)Motivation of pursuing succeed plays partial mediating effect between self-esteem and learning burnout,but mediating effect of avoiding failure motivation between them is not significant.The study reveals that:the degree of learning burnout can be reduced by improving college students’level of self-esteem. | MENG Xiangyin ZHANG Lei OU Guiyu | 2023 | Psychology Research2023，13，7： | 0 |
| 16 | Enhancing methanol biotransformation for overproducing fatty显示文摘Excess amount of CO_(2) in the atmosphere is one of the major causes of the greenhouse effect and global warming[1].CO_(2),a promising feedstock for bio-refinery,its efficient utilization is challenging due to its stable structure and low energy state[2,3].However,small energetic compounds like methanol become a bridge and bond of efficient CO_(2) transformation[4,5].Therefore,methanol biotransformation via microbial cell factories will pave the way for sustainable production of value-added chemicals. | Xiangyin Chen Jiaming Yu Lixin Zhang | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 17 | Computational prediction and validation of specific EmbR binding site on PknH显示文摘Tuberculosis drug resistance continues to threaten global health but the underline molecular mechanisms are not clear.Ethambutol(EMB),one of the well-known first-line drugs in tuberculosis treatment is,unfortunately,not free from drug resistance problems.Genomic studies have shown that some genetic mutations in Mycobacterium tuberculosis(Mtb)EmbR,and EmbC/A/B genes cause EMB resistance.EmbR-PknH pair controls embC/A/B operon,which encodes EmbC/A/B genes,and EMB interacts with EmbA/B proteins.However,the EmbR binding site on PknH was unknown.We conducted molecular simulation on the EmbR-peptides binding structures and discovered phosphorylated PknH 273-280(N′-HEALS^(P)DPD-C′)makesβstrand with the EmbR FHA domain,asβ-MoRF(MoRF;molecular recognition feature)does at its binding site.Hydrogen bond number analysis also supported the peptides’β-MoRF forming activity at the EmbR FHA domain.Also,we discovered that previously known phosphorylation residues might have their chronological order according to the phosphorylation status.The discovery validated that Mtb PknH 273-280(N′-HEALSDPD-C′)has reliable EmbR binding affinity.This approach is revolutionary in the computer-aided drug discovery field,because it is the first trial to discover the protein-protein interaction site,and find binding partner in nature from this site. | Insung Na Huanqin Dai Hantian Li Anvita Gupta David Kreda Powell Zhang Xiangyin Chen Lixin Zhang Gil Alterovitz | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 0 |
| 18 | Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kαinhibitors显示文摘Phosphatidylinositol 3-kinase alpha(PI3Kα)inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma(ESCC).It is of great importance to identify potential biomarkers to predict or monitor the efficacy of PI3Kαinhibitors in an aim to improve the clinical responsive rate in ESCC.Here,ESCC PDXs with CCND1 amplification were found to be more sensitive to CYH33,a novel PI3Kα-selective inhibitor currently in clinical trials for the treatment of advanced solid tumors including ESCC.Elevated level of cyclin D1,p21 and Rb was found in CYH33-sensitive ESCC cells compared to those in resistant cells.CYH33 significantly arrested sensitive cells but not resistant cells at G1 phase,which was associated with accumulation of p21 and suppression of Rb phosphorylation by CDK4/6 and CDK2.Hypo-phosphorylation of Rb attenuated the transcriptional activation of SKP2 by E2F1,which in turn hindered SKP2-mediated degradation of p21 and reinforced accumulation of p21.Moreover,CDK4/6 inhibitors sensitized resistant ESCC cells and PDXs to CYH33.These findings provided mechanistic rationale to evaluate PI3Kαinhibitors in ESCC patients harboring amplified CCND1 and the combined regimen with CDK4/6 inhibitors in ESCC with proficient Rb. | Xu Zhang Yuxiang Wang Xi Zhang Yanyan Shen Kang Yang Qingyang Ma Yuemei Qiao Jiajie Shi Yi Wang Lan Xu Biyu Yang Gaoxiang Ge Landian Hu Xiangyin Kong Chunhao Yang Yi Chen Jian Ding Linghua Meng | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 19 | MicroRNA or NMD:Why Have Two RNA Silencing Systems?显示文摘MicroRNA(miRNA)-mediated RNA silencing and nonsense-mediated decay(NMD) are two conserved RNA-level regulatory pathways.Although they are mechanically different,both can regulate target genes by RNA degradation and translational repression.Moreover,studies of individual target genes indicated that these two pathways can be involved in the same processes(e.g.,development and stress responses).These facts raise an important question that whether these two systems are cooperative,interchangeable or optimal for regulation of different sorts of genes.We addressed this by comparing miRNA and NMD targets in Arabidopsis thaliana at the genome-wide scale.We find no more overlap in the genes targeted by both systems than expected by chance.Moreover,the sorts of genes or pathways regulated by these systems are categorically different on several cross-correlating fronts.While miRNA targets show enrichment in the process of development,metabolism and transcription,NMD targets are associated with stress responses but otherwise poorly annotated.Validated miRNA targets are more highly expressed,less variably expressed and slower evolving.These differences suggest that the modes of regulation need not be interchangeable.Instead,we suggest that miRNA genes are commonly dose-sensitive and require fine control of levels through weak pull-down by miRNAs.This is consistent with miRNA-regulated genes being more likely to be involved in proteine protein interactions.Many NMD-regulated genes,by contrast,have properties consistent with them being rapid emergency response 'fire-fighter' genes.If true,the lack of annotation of NMD targets suggests that we poorly understand the emergencies plants face in the wild. | Zhenguo Zhang Landian Hu Xiangyin Kong | 2013 | Journal of Genetics and Genomics2013，40，10： | 0 |
| 20 | Determination of thorium in the hair and urine of workers and the public in a rare earth mining area显示文摘Objective:To assess the thorium exposure of the mine workers and the public to a typical rare earth mine and estimate the resultant committed effective dose to them.Methods:A total of 79 volunteers were selected in this survey,including 69 mine workers and 10 local residents living about 4 km away from the mine site.Urinary samples were collected from 79 volunteers,with 65 hair samples from 57 workers and 8 local residents.The thorium concentrations in urinary and hair samples were determined by using inductively coupled plasma mass spectrometry.The committed effective doses were estimated based on the urinary samples collected and the parameters as recommended by ICRP Publication 137.Results:Thorium concentrations in the samples from the workers ranged from 19.0 to 2388.8 ng/g in hair with median of 149.8 ng/g,and in urine 18.3–906.1 ng/L with median of 59.6 ng/L,respectively.The median values of thorium concentrations were 11.8 ng/g in hair and 32.40 ng/L in urine for the public respectively.The thorium concentrations in urinary and hair samples of the workers were not only higher than those of the residents in the local area,but also than those of non-occupationally exposed populations as reported.The median values of committed effective dose were estimated to be 1.51 mSv for the workers and 781μSv for the local residents,respectively.Conclusions:The residents in the local area,and especially the workers,have been subject to long term thorium exposure.More attention should be paid to the radiological hazards of thorium to the workers and local residents. | Yao Zhang Xianzhang Shao Xiangyin Kong Liangliang Yin Chengguo Wang Liang Lin Yanqin Ji | 2022 | Radiation Medicine and Protection2022，3，2： | 0 |
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