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| 1 | Gene expression of fibrinolytic factors urokinase plasminogen activator and plasminogen activator inhibitor-1 in rabbit temporo-mandibular joint cartilage with disc displacement显示文摘Background The urokinase plasminogen activator system is believed to play an important role in degradation of the extracellular matrix associated with cartilage and bone destruction; however its precise roles in temporomandibular disorders have not yet been clarified. The aims of this study were to investigate the gene expression of fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in the articular cartilage of rabbit temporomandibular joint (TMJ) with disc displacement (DD) and to probe the relationship between fibrinolytic activity and cartilage remodeling. Methods Disc displacement of right joints was performed in 36 of 78 rabbits under investigation. The animals were sacrificed at 4 days and 1, 2, 4, 8 and 12 weeks after surgery, respectively. The right joints of these animals were harvested and processed for the examination of mRNA expression of uPA and PAI-1 in articular cartilage using in situ hybridization techniques. Results The expression of uPA and PAI-1 was co-expressed weakly in the chondrocytes from transitive zone to hypertrophic zone and mineralized zone, while no hybridizing signals were shown in proliferative zone and superficial zone in control rabbits. The most striking was the up-regulation of uPA and PAI-1 mRNA in 4-day rabbits postoperatively at the onset of cartilage degeneration. The strongest hybridizing signals for uPA and PAI-1 were seen in 2-week rabbits postoperatively. After 2 weeks, the expression of uPA and PAI-1 began to decrease and reached nearly normal level at 12 weeks. Conclusions The expression of the uPA/PAI-1 system coincides with the pathological changes in condylar cartilage after DD. The uPA/PAI-1 system may be one of the essential mediators in articular cartilage remodeling. | ZHANJing GUZhi-yuan WULi-qun ZHANGYin-kai HUJi-an | 2005 | Chinese Medical Journal2005，，12： | 3 |
| 2 | Significance of MD-2 and MD-2B expression in rat liver during acute cholangitis显示文摘AIM: To investigate the expression of myeloid differentiation protein-2 (MD-2), MD-2B (a splicing isoform of MD-2 that can block Toll-like receptor 4 (TLR4)/MD-2 LPS-mediated signal transduction) and TLR4 in the liver of acute cholangitis rats. METHODS: Male Sprague-Dawley rats (SPF level) were randomly divided into four groups: (A) sham-operated group; (B) simple common bile duct ligation group; (C)acute cholangitis group; and (D) acute cholangitis anti- TLR4 intervention group (n = 25 per group). Rat liver tissue samples were used to detect TLR4, MD-2 and MD-2B mRNA expression by fluorescence quantitative PCR in parallel with pathological changes. RESULTS: In acute cholangitis, liver TLR4 and MD-2 mRNA expression levels at 6, 12, 24, 48 and 72 h were gradually up-regulated but MD-2B mRNA expression gradually down-regulated (P < 0.05). After TLR4 antibody treatment, TLR4 and MD-2 mRNA expression were lower compared with the acute cholangitis group (P < 0.05). However, MD-2B mRNA expression was higher than in the acute cholangitis group (P < 0.05). MD-2 and TLR4 mRNA expressions were positively correlated (r = 0.94981, P < 0.05) and MD-2B mRNA expression was negatively correlated with MD-2 and TLR4 mRNA (r = -0.89031, -0.88997, P< 0.05). CONCLUSION: In acute cholangitis, MD-2 plays an important role in the process of TLR4- mediated in? am- matory response to liver injury while MD-2B plays a negative regulatory role. | Hui-Lai Miao, Zhi-Dong Qiu, Fu-Long Hao, Yong-Hui Bi, Ming-Yi Li, Ming Chen, Nian-Ping Chen, Fei Zhou, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical College, Zhanjing 524001, Guangdong Province, China Hepatobiliary Surgery, Research Institute of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China | 2010 | World Journal of Hepatology2010，2，6： | 3 |
| 3 | Outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy 显示文摘 | Sliwa K Forster O Zhanje F | 2004 | Am J Cardiol2004，93，11： | 1 |
| 4 | Oralhydrogenwaterpreventschronicallograftnephropathyinrats显示文摘 | CardinalJS ZhanJ WangY etal | 2010 | KidneyInt2010，77，2： | 1 |
| 5 | On ( ^-∈ ,^- ∈ ∨ ^-q)-fuzzyideals of BCI-algebras显示文摘 | ZHANJ M JUNY B | 2010 | Neural Comput & Appl2010，10，2： | 1 |
| 6 | Transport characteristics of nanoscale functional zerovalent iron/silica composites for in si- tu remediation of trichloroethylene显示文摘 | ZhanJ J Zheng T H Piringer G | 2008 | Environmental Science and Technology2008，42，23： | 1 |
| 7 | Outcome of subse-quent pregnancy in patients with documented peripartumcardiomyopathy显示文摘 | Sliwa K Forster O Zhanje F | 2004 | Am J Cardiol2004，93，14： | 1 |
| 8 | 快速三点Dixon的T2加权脊柱成像与化学位移选择性脂肪抑制的比较[J]显示文摘 | 马竞飞 SinghSK KumarAJ LeedsNE ZhanJ | | 磁共振成像杂志0，，： | 1 |
| 9 | Isolation and analysis of water stress induced gene s in maize seed lings by subtract ive PCR and eDNA macroarray显示文摘 | ZhengJ ZhanJ F ZhaoY Z Tao Y Z WangJ H Liu YJ FuJ J Jin Y Gao P ZhangJ P Bai Y F Wang G Y | 2004 | Plant Molecular Biology2004，55，6： | 1 |
| 10 | Outcome of subsequent pregnancy in patients with documented peripartum cardionyopathy显示文摘 | SLIWA K FORSTER O ZHANJE F | 2004 | The American Journal of Cardiology2004，93，11： | 1 |
| 11 | Synthesis of Ag2Se by sonoehemical reaction of Se with AgNO3 in non aqueous solvent 显示文摘 | ZhanJ H Yang X G Li SD WangDW Xie Y | 2001 | Int J Inorg Mater2001，3，： | 1 |
| 12 | Adaptive particle swarm optimization显示文摘 | Zhi-hui ZhanJ Zhang Y Li | 2009 | IEEE Transactions on Systems Man and Cybernetics2009，39，6： | 1 |
| 13 | Large-energy,wavelength-tunable, all -fiber passively Q -switched Er:Yb-codoped double-clad fiber laser with mono-layer chemicalvapor deposition graphene 显示文摘 | Wu D D Xiong F F Zhanj C K | 2014 | Applied Optics2014，53，19： | 1 |
| 14 | A New Fifth-Order Finite Volume Central WENO Scheme for Hyperbolic Conservation Laws on Staggered Meshes显示文摘In this paper,a new fifth-order finite volume central weighted essentially non-oscillatory(CWENO)scheme is proposed for solving hyperbolic conservation laws on staggered meshes.The high-order spatial reconstruction procedure using a convex combination of a fourth degree polynomial with two linear polynomials(in one dimension)or four linear polynomials(in two dimensions)in a traditional WENO fashion and a time discretization method using the natural continuous extension(NCE)of the Runge-Kutta method are applied to design this new fifth-order CWENO scheme.This new finite volume CWENO scheme uses the information defined on the same largest spatial stencil as that of the same order classical CWENO schemes[37,46]with the application of smaller number of unequal-sized spatial stencils.Since the new nonlinear weights are adopted,the new finite volume CWENO scheme could obtain the same order of accuracy and get smaller truncation errors in L1 and L¥norms in smooth regions,and control the spurious oscillations near strong shocks or contact discontinuities.The new CWENO scheme has advantages over the classical CWENO schemes[37,46]on staggered meshes in its simplicity and easy extension to multi-dimensions.Some one-dimensional and two-dimensional benchmark numerical examples are provided to illustrate the good performance of this new fifthorder finite volume CWENO scheme. | Shengzhu Cui Zhanjing Tao Jun Zhu | 2022 | Advances in Applied Mathematics and Mechanics2022，14，5： | 0 |
| 15 | An Adaptive Multiresolution Ultra-weak Discontinuous Galerkin Method for Nonlinear Schrödinger Equations显示文摘This paper develops a high-order adaptive scheme for solving nonlinear Schrödinger equa-tions.The solutions to such equations often exhibit solitary wave and local structures,which make adaptivity essential in improving the simulation efficiency.Our scheme uses the ultra-weak discontinuous Galerkin(DG)formulation and belongs to the framework of adaptive multiresolution schemes.Various numerical experiments are presented to demon-strate the excellent capability of capturing the soliton waves and the blow-up phenomenon. | Zhanjing Tao Juntao Huang Yuan Liu Wei Guo Yingda Cheng | 2022 | Communications on Applied Mathematics and Computation2022，4，1： | 0 |
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