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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 3 | Modern seismic methods in engineering investigation at a nuclear power plant site显示文摘 | Zhao Y G Jin H X Wang C F | 1996 | Scientia Geologica Sinica1996，5，4： | 1 |
| 4 | Automotive spark-ignited direct-injection gasoline engines显示文摘 | Zhao F Lai M C Harrington D L | 1999 | Progress in Energy and Combustion Science1999，25，： | 1 |
| 5 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 6 | Long-term evaluation of adsorption capacity in a biological activated carbon fluidized bed reactor system 显示文摘 | Zhao X Hickey R F Voice T C | 1999 | Water Research1999，33，： | 1 |
| 7 | Phytotoxicity of nickel in a range of European soils:Influence of soil properties, Ni solubility and speciation 显示文摘 | Rooney C P Zhao F J McGrath S P | 2007 | Environmental Pollution2007，145，： | 1 |
| 8 | Expression of bovine trypsin in Lactococcus lactis显示文摘 | Yao L Man C Zhao F | 2010 | Int Dairy J2010，20，11： | 1 |
| 9 | Newly synthesized dyes and their polymer/Glass composites for one-and two-photon pumped solid-state cavity lasing显示文摘 | Zhao C F He G S Bhawalkar J D | 1995 | Chem Mater1995，，7： | 1 |
| 10 | New kinematic structures for 2-,3-,4-,and 5-DOF parallel manipulator designs显示文摘 | Gao F Li W M Zhao X C | 2002 | Mechanism and Machine Theory2002，37，11： | 1 |
| 11 | Accentuating Your Masculine Side: Agentic Traits Generally Dominate Self-Evalua tion, Even in China 显示文摘 | BI C Z YBARRA O ZHAO Y F | 2013 | Social Psychology2013，44，2： | 1 |
| 12 | Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia 显示文摘 | Chao MP Alizadeh AA Tang C Jan M Weissman-Tsukamoto R Zhao F | 2011 | Cancer Res2011，71，4： | 1 |
| 13 | Particle stick- ing behavior near the throat of a low-NOx Lxial-swirl coal burner 显示文摘 | Li Z Q Zeng L Y Zhao G B Shen S P Zhang F C | 2011 | Applied Energy2011，88，： | 1 |
| 14 | Suppression of matrix metallo- proteinase-9 expression by RNA interference inhibits SGC7901 gastric adenocarcinoma cell growth and invasion in vitro and in vi- vo显示文摘 | Zhao F Zhang Q Kang C | 2010 | Med Oncol2010，27，3： | 1 |
| 15 | Long-term outcomes and prog- nostic factors of re-irradiation for locally recurrent nasopharyngeal carcinoma using intensity-modulated radiotherapy 显示文摘 | Han F Zhao C Huang SM | 2012 | Clin Oncol (R Coil Radiol)2012，24，8： | 1 |
| 16 | Using CD133 positive U251 glioblastoma stem cells to establish nude mice model of transplanted tumor 显示文摘 | Jin F Gao C Zhao L | 2011 | Brain Res2011，1368，： | 1 |
| 17 | Automotive spark-ignited direct-injection gasoline engines显示文摘 | Zhao F Lai M C Harrington D L | 1999 | Energy and Combustion Science1999，25，： | 1 |
| 18 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 19 | Diffusion and swelling behavior in treatment of oil spill to semi-interpenetrating polymer network from oil-absorptive fiber 显示文摘 | ZHAO J XIAO C F XU N K | 2012 | Journal of Dispersion Science and Technology2012，33，： | 1 |
| 20 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
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