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| 1 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 2 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 3 | Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. | Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun Lina Fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu | 2019 | Protein & Cell2019，10，4： | 7 |
| 4 | Study of welding technology on Baosteel high-strength heavy steel Bweldy620QL6显示文摘This study aims to conduct the weldability test for a high-strength structural steel,Bweldy620 QL6,developed by Baosteel.This steel was subjected to welding,and the effects of two kinds of shielding gas,a binary gas of 80%Ar +20%CO_2 and ternary gas of 90% Ar +8%CO_2 +2%O_2,on the performance of the welded joints of high-strength heavy steel were compared.The results show that Bweldy620 QL6 has good weldability,and the joints obtained using binary gas and ternary gas meet common requirements. | QU Zhaoxia XIA Liqian ZHU Shuangchun | 2018 | Baosteel Technical Research2018，12，2： | 2 |
| 5 | Industrial-Scale Polypropylene–Polyethylene Physical Alloying Toward Recycling显示文摘Polypropylene(PP)and polyethylene(PE)play central roles in our daily life.However,their immiscibility presents a major hurdle in both industry and academia when recycling them into alloys with favorable mechanical properties.Moreover,typical compatibilizer-enabled approaches are limited due to increased environmental concerns.Herein,inspired by a traditional Chinese technique,we report a facile,industry-scale methodology that produces a PP/PE binary blend with a highly ordered honeycomb nanostructure without any additives.Due to its nanostructure,the blend exhibits enhanced tensile properties in com-parison with the parent components or with a sample prepared using an internal mixer.This approach has potential for applications not only in immiscible polymer blending,but also in non-sorting,compatibilizer-free waste plastics recycling.Through this technique,we expect that an environmentally friendly and sustainable plastic wastes recycling avenue can be found,and great economic benefits can be gained. | Jinping Qu Zhaoxia Huang Zhitao Yang Guizhen Zhang Xiaochun Yin Yanhong Feng Hezhi He Gang Jin Ting Wu Guangjian He Xianwu Cao | 2022 | Engineering2022，8，2： | 2 |
| 6 | Differential roles of STAT3 in the initiation and growth of lung cancer显示文摘 | JINGJIAO ZHOU ZHAOXIA QU SHAPEI YAN | 2015 | Oncogene2015，34，29： | 1 |
| 7 | Laboratory development of high performance steel plates with excellent HAZ toughness at large heat inputs显示文摘Presented in this study is the result of steel plates developed at laboratory by using the technique of chemistry design based on microstructure evolution.It has been shown that the produced 50mm thickness steel plates with yield and tensile strength being 420 MPa and 530 MPa respectively exhibit excellent large heat input weldability:the Charpy impact tests in the whole range of heat affected zone(HAZ) including the fusion line at the welded joint with large heat input of 100 -300 kJ/cm showed uniform impact toughness of above 140 J at -40℃.Welding simulations were also performed for heat inputs of 200-600 kJ/cm,which showed far better toughness at -20℃.Analysis on the results of the simulations and the practical welding tests were done and the microstructure evolution mechanisms were proposed.Finally suggestions were given to improve the simulation processes as well as chemistry modification. | WANG Wei,WANG Huanrong,BAI Yan,CAO Neng,QU Zhaoxia,WANG Haitao and LIU Gang Research Institute,Baoshan Iron & Steel Co.,Ltd.,Shanghai 201900,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 8 | A novel aluminum-carbon nanotubes nanocomposite with doubled strength and preserved electrical conductivity显示文摘Enhancing the mechanical strength of highly conductive pure metals usually causes significant reduction in their electrical conductivity.For example,introducing phase/matrix interfaces or more grain boundaries,are common and effective methods to strengthen metals.But it simultaneously increases the electron scattering at the interface,thus reducing the electrical conductivity.In this study,we demonstrate that pure aluminum(Al)/carbon nanotubes(CNTs)nanocomposites prepared by friction stir processing have successfully broken through these limitations.The yield strength and tensile strength of Al/CNTs nanocomposites have improved by 104.7%and 51.8%compared to pure Al,while the electrical conductivity remained comparable to that of pure Al.To explore the potential mechanisms,the interface between CNTs and Al was examined and characterized by transmission electron microscopy(TEM)and Raman spectroscopy.Little interfacial reaction compounds were present and no visible physical gaps were observed at CNTs and Al interfaces.We defined it as a clean and tightly bonded interface.Although the quantity of phase interface has increased,the electrical conductivity of the nanocomposite remains approximately unchanged.We attribute the preserved electrical conductivity to the clean and tightly bonded CNTs/Al interface in the nanocomposite. | Shuai Zhang Gaoqiang Chen Timing Qu Jinquan Wei Yufan Yan Qu Liu Mengran Zhou Gong Zhang Zhaoxia Zhou Huan Gao Dawei Yao Yuanwang Zhang Qingyu Shi Hua Zhang | 2021 | Nano Research2021，14，8： | 1 |
| 9 | Preface显示文摘Baoshan Iron&Steel Co.,Ltd.(Baosteel)is well known for producing various steel products based on user requirements.According to the chemical composition of the produced steels,carbon steel is the main product,while other products include stainless steel and special steel.Most steels are provided as plates,but other forms,such as pipes and wires,are also provided.On the basis of applications,the steel products can be classified as high-strength steel。 | QU Zhaoxia | 2018 | Baosteel Technical Research2018，12，2： | 0 |
| 10 | Numerical simulation of temperature field in laser-arc hybrid welding of wear-resistant steel显示文摘Using ABAQUS software and cylindrical ellipsoid and body heat sources with a peak-heat-fluxattenuation function,a finite element model of the temperature field in the laser-arc hybrid welding of 4.5-mm BW300 TP wear-resistant steel is proposed.The proposed model considers convection,radiation,molten pool flow,and heat conduction effect on temperature.A comparison of the simulation and actual welding test results confirms the reliability of the model.This welding heat-process model can provide the cooling rate at any position in the heat affected zone(HAZ) and can be used as a reference for the analysis of material properties and for process optimization. | WANG Xiaojie QU Zhaoxia XIA Liqian | 2018 | Baosteel Technical Research2018，12，2： | 0 |
| 11 | Research on welding technology of hot-rolled extra-high-strength steel developed by Baosteel显示文摘In this study,the welding technology of the hot-rolled extra-high-strength steel,BS960QC,has been comprehensively investigated.Analysis has been made on the weldability,the different welding procedures,the mechanical properties,and the fatigue properties,and a set of recommendation guidelines have been proposed for evaluating the welded joints of the extra-high-strength steel.The research and results indicate that the hot-rolled extra-high-strength steel,BS960QC,has good weldability and an excellent adaptability to welding procedures.Further,the excellent mechanical properties and fatigue properties of the welded joints,which can be achieved by using optimized welding procedures,can completely meet the technical requirements of the construction machinery industry. | QU Zhaoxia WANG Haitao XU Lei | 2013 | Baosteel Technical Research2013，7，3： | 0 |
| 12 | Microstructural analysis of the softened zone in the welding joint of 100 kg class hot-rolled extra-high-strength steel显示文摘Using the Gleeble 3500 thermal-mechanical system to simulate thermal cycles with different peak temperatures,the hardness and microstructure in the heat-affected zones of two kinds of 100 kg class hot-rolled extra-high-strength steel were compared.When the peak temperature of the thermal cycle was 800℃,incomplete transformation occurred during quenching in both steels,and massive martensite and bainite grains were formed.The hardness was determined by the composition and distribution of the microstructure.The concentration of massive martensite was low,and hence the hardness was low,in steel#1.Conversely,the massive martensite content in steel#2 was high and uniformly distributed,resulting in a high hardness.These findings can provide a reference for improving the mechanical properties in the softened zone. | WANG Haitao QU Zhaoxia XU Lei | 2013 | Baosteel Technical Research2013，7，3： | 0 |
| 13 | Twin-wire SAW welding of 70 kg class high strength steel显示文摘The twin-wire SAW welding process was investigated using Baosteel 70 kg class high strength steel,and the properties of the joints were studied using conventional single and double-faced grooves as well as an optimized groove.The results showed that by using an optimized double-faced groove,a small root face,and no back gouging,a small welding heat input was achieved and thus the joint strength and toughness were improved significantly.Also,removing back gouging reduced the labor required in the process.The weld reinforcement and deformation were observed to be rather small. | XU Lei QU Zhaoxia WANG Haitao | 2013 | Baosteel Technical Research2013，7，3： | 0 |
| 14 | Advances in China Space Medical Experiment Research显示文摘In 2021,China Space Station(CSS)was assembled and constructed in-orbit,which provided a broad space platform for space medicine and space life sciences research.Space medicine focuses on the systematic risks that restrict long-term manned spaceflight.It carries out systematic research on the impact and countermeasure technology of long-term weightlessness on astronauts’health,space radiation on astronauts’health,behavior and ability,advanced on-orbit monitoring and medical disposal technology,and traditional space medical application technology by the space medicine experiment platform on human body and cell.It has accumulated valuable data on space environmental effects and human factors research,established a“human system risk”research system,obtained new knowledge and discoveries of space medicine,and explored countermeasure technologies of new characteristics.Moreover,a series of achievements have been made in the basic research on the mechanism of the special space environmental effect,which provides a solid foundation for the implementation of space missions. | CHEN Hailong LIU Zhaoxia WANG Lidong DING Bai SHI Liujia WANG Chunyan MI Tao YU Hongqiang ZHAO Rui WANG Honghui CHEN Chao QU Lina MA Honglei JIANG Changhua LI Yongzhi WEI Ming LI Zhili XU Chong ZANG Peng CAO Ping LI Yinghui | 2022 | 空间科学学报2022，42，4： | 0 |
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