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| 1 | Correlation between the Amplitude of Glucose Excursion and the Oxidative/Antioxidative System in Subjects with Different Types of Glucose Regulation显示文摘Objective To investigate effects of glucose excursion on the oxidative/antioxidative system in subjects with different types of glucose regulation. Methods A total of 30 individuals with normal glucose regulation (NGR), 27 subjects with impaired glucose regulation (IGR) and 27 subjects with newly diagnosed type 2 diabetes mellitus (T2DM) were selected and recruited for 3 days' continuous glucose monitor system (CGMS) assessment. The data from CGMS was used to calculate the mean amplitude of glycemic excursion (MAGE), mean blood glucose (MBG) and its standard deviation (SDBG), area under the ROC curve when the blood glucose >5.6 mmol/L within 24 h (AUC 5.6), mean of daily differences (MODD), and mean postprandial glucose excursion (MPPGE). In all groups, the content or activity of malondialdehyde (MDA), total antioxidation capacity (TAOC) and glutathione peroxidase (GSH‐Px) were detected. Results Glucose excursion parameters of subjects with T2DM or IGR were higher than those of NGR subjects (P<0.05 or 0.01). Moreover, Glucose excursion parameters of T2DM subjects were higher than those of IGR subjects (P<0.05 or 0.01). Subjects with T2DM or IGR had significant higher MDA levels and lower GSH‐Px/MDA and TAOC/MDA levels compared to NGR subjects (P<0.01). T2DM subjects had even higher MDA levels and lower GSH‐Px/MDA levels than IGR (P<0.05 or 0.01). According to the median of normal population for MAGE, T2DM and IGR subjects were divided into MAGE>2.6mmol/L Group and MAGE≤2.6mmol/L Group. MAGE>2.6mmol/L Group had higher levels of MDA and lower levels of GSH‐Px/MDA than MAGE≤2.6mmol/L Group (P<0.05). There was no significant difference between the two groups (P>0.05) in terms of the levels of TAOC/MDA. Pearson correlation analysis showed that MDA was positively correlated with FPG, 2hPG, MAGE, and SBP. GSH‐Px/MDA was negatively correlated with MAGE and TC. TAOC/MDA was negatively correlated with FPG. Partial correlation analysis showed that the relationship between MDA and MAGE, GSH‐Px/MDA, and MAGE remained significant after adjustments for the other differences among groups. Conclusion Glucose excursion contributed significantly to promoting lipid peroxidation and decreasing antioxidation capacity than chronic sustained hyperglycemia did in the subjects with different types of glucose regulation. | WANG Zhou LI Lin ZHENG FenPing JIA ChengFang RUAN Yu LI Hong | 2011 | Biomedical and Environmental Sciences2011，24，1： | 6 |
| 2 | An intensive study on aerosol optical properties and affecting factors in Nanjing,China显示文摘The optical properties of aerosol as well as their impacting factors were investigated at a suburb site in Nanjing during autumn from 14 to 28 November 2012. More severe pollution was found together with lower visibility. The average scattering and absorption coefficients(B sca and B abs) were 375.7 ± 209.5 and 41.6 ± 18.7 Mm^(-1), respectively. Higher ?ngstr?m absorption and scattering exponents were attributed to the presence of more aged aerosol with smaller particles. Relative humidity(RH) was a key factor affecting aerosol extinction. High RH resulted in the impairment of visibility, with hygroscopic growth being independent of the dry extinction coefficient. The hygroscopic growth factor was 1.8 ± 1.2 with RH from 19% to 85%.Light absorption was enhanced by organic carbon(OC), elemental carbon(EC) and EC coatings,with contributions of 26%, 44% and 75%(532 nm), respectively. The B sca and B abs increased with increasing N_(100)(number concentration of PM_(2.5)with diameter above 100 nm), PM_1 surface concentration and PM_(2.5)mass concentration with good correlation. | Fenping Cui Mindong Chen Yao Ma Jun Zheng Zhou Yaoyao Shizheng Li Lu Qi Li Wang | 2016 | Journal of Environmental Sciences2016，28，2： | 6 |
| 3 | Bilateral adrenal tumor: causes and clinical features in eighteen cases显示文摘 | Jiaqiang Zhou Dan Ye Meihua Wu Fenping Zheng Fang Wu Zhou Wang Hong Li | 2009 | International Urology and Nephrology2009，，3： | 1 |
| 4 | Rela- tionships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glueo-regulation 显示文摘 | Zheng Fenping Lu Weina Jia Chengfang | 2010 | Endocrine2010，37，1： | 1 |
| 5 | Knockdown of insulin-like growth factor 2 gene disrupts mitochondrial functions in the liver显示文摘Even though insulin-like growth factor 2(IGF2)has been reported to be overexpressed in nonalcoholic fatty liver disease(NAFLD),its role in the progression of NAFLD and the potential mechanism remain largely unclear.Using in vitro models,we found that IGF2 was the key overexpressed gene in steatosis,suggesting a possible association between IGF2 and NAFLD.Interestingly,loss-of-function experiments revealed that inhibition of IGF2 protein impaired mitochondrial biogenesis and respiration.It additionally disrupted the expression changes of mitochondrial fusion and fission-related proteins necessary in maintaining mitochondrial homeostasis.Consistently,IGF2 knockdown reduced the mitochondrial membrane potential and increased the production of reactive oxygen species.Mechanistically,IGF2 regulates mitochondrial functions by modulating the expression of SIRT1 and its downstream gene PGCla.This research opens a new frontier on the role of IGF2 in energy metabolism,which potentially participates in the development of NAFLD.As such,IGF2 is a potential therapeutic target against NAFLD. | Weiwei Gui Yiyi Zhu Shuiya Sun Weifen Zhu Bowen Tan Hanxin Zhao Chengxin Shang Fenping Zheng Xihua Lin Hong Li | 2021 | Journal of Molecular Cell Biology2021，13，8： | 1 |
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