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| 1 | Heyan Kuntai capsule versus dehydroepiandrosterone in treating Chinese patients with infertility caused by diminished ovarian reserve: a multicenter, randomized controlled trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR. | Gao Hui Xia Tian Ma Ruihong Zhao Zhimei Song Xueru Wang Baojuan Liu Lijing Han Kaimei Wang Guoqing Fu Yu Hao Guimin | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 14 |
| 2 | Off-flavor compounds from decaying cyanobacterial blooms of Lake Taihu显示文摘The effect of cyanobacterial bloom decay on water quality and the complete degradation of cyanobacterial blooms in a short period were examined by an enclosure experiment in Gonghu Bay of Lake Taihu,China.Water quality parameters as well as taste and odor compounds during the breakdown of cyanobacterial blooms were measured.Results showed that the decay of cyanobacterial blooms caused anoxic water conditions,decreased pH,and increased nutrient loading to the lake water.The highest concentrations of dimethyl sulfide (DMS),dimethyl trisulfide (DMTS),and β-cyclocitral were observed in the anoxic water,at 62331.8,12413.3,and 1374.9 ng/L,respectively.2-Methylisoborneol was dominant during the live growth phase of cyanobacterial blooms,whereas DMS and DMTS were dominant during the decomposition phase.Dissolved oxygen,pH,and chlorophyll a were negatively correlated with DMS,DMTS,and β-cyclocitral,whereas total phosphorus,total nitrogen,and ammonium (NH4+-N) were positively correlated with DMS,DMTS,β-cyclocitral,and β-ionone.The experimental results suggested that preventing the anaerobic decomposition of cyanobacterial blooms is an important strategy against the recurrence of a malodor crisis in Lake Taihu. | Zhimei Ma Yuan Niu Ping Xie Jun Chen Min Tao Xuwei Deng | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 3 | Impacts of water conservancy and soil conservation measures on annual runoff in the Chaohe River Basin during 1961-2005显示文摘Taking the Chaohe River Basin above the Miyun Reservoir in North China as a study area,the characteristics and variation trends of annual runoff and annual precipitation during 1961-2005 were analyzed applying Mann-Kendall test method on the basis of the hydrologic data of the major hydrological station(Xiahui Station) located at the outlet of the drainage basin and the meteorological data of 17 rainfall stations.Human activities including water conservancy projects construction and water diversion as well as implementation of soil and water conservation from 1961 to 2005 were carefully studied using time series contrasting method.The referenced period(1961-1980) that influenced slightly by human activities and the compared period(1981-2005) that influenced significantly by water conservancy and soil conservation measures were identified according to the runoff variation process analysis and abrupt change points detection during 1961-2005 applying double accumulative curve method,mean shift t-test method and Mann-Kendall mutation test technique.Based on the establishment of a rainfall-runoff empirical statistical model,impacts and the runoff-reducing effects of water conservancy and soil conservation measures on runoff reduction were evaluated quantitatively.The major results could be summarized as follows:(1) The annual precipitation in the drainage basin tends to decrease while the runoff has declined markedly since the 1960s,the average annual runoff from 1991 to 2000 was only 90.9% in proportion to that from 1961 to 1970.(2) The annual runoff variations in the drainage basin are significantly related to human activities.(3) During 1981-1990,1991-2000,2001-2005 and 1981-2005,the average annual runoff reduction amounts were 1.15×108,0.28×108,1.10×108 and 0.79×108 m3 respectively and the average annual runoff-reducing effects were 31.99%,7.13%,40.71% and 23.79% accordingly.Runoff-reducing effects by water conservancy and soil conservation measures are more prominent in the low water period. | LI Zijun LI Xiubin XU Zhimei | 2010 | Journal of Geographical Sciences2010，20，6： | 8 |
| 4 | Effect of rare earth elements on the structures and mechanical properties of magnesium alloys显示文摘By means of first-principles calculations,we have investigated the effects of rare earth elements (REEs) on the structures and mechanical properties of magnesium.The lattice parameters,elastic constants,bulk moduli,shear moduli,Young's moduli and anisotropic parameter of these solid solutions have been calculated and analyzed.The nearest-neighbor distance between Mg and the REEs is also analyzed to explore the correlation with the bulk moduli.The results show that the 4f-electrons and atomic radii play an important role in the strengthening process.The anomalies of the lattice parameters and mechanical properties at Eu and Yb are due to the half-filled and full-filled 4f-electron orbital states.Finally,the increase of directional bonding character near the alloying elements may account for the anisotropy and brittleness of these magnesium alloys. | L Zhong ZHOU Jian SUN ZhiMei CHEN RongShi | 2013 | Science China(Technological Sciences)2013，56，3： | 8 |
| 5 | First-principles calculations of the β'-Mg_7Gd precipitate in Mg-Gd binary alloys显示文摘The metastable β' phase is often the most effective hardening precipitate in Mg-Gd based alloys.In this paper,the structural,elastic and electronic properties of the recently identified β'-Mg7Gd precipitate in Mg-Gd binary alloys were investigated using first-principles calculations based on density functional theory.The lattice mismatches between the coherent β'-Mg7Gd precipitate and α-Mg matrix are discussed and used to rationalize the experimentally observed morphology of the precipitate.The mechanical properties were investigated through analysis of the single-crystal elastic constants and the polycrystalline elastic moduli.It is found that β'-Mg7Gd is brittle in nature.Strong covalent bonding in β'-Mg7Gd,as inferred from its electronic structure,further explains its mechanical properties.Our theoretical results show good agreement with experimental measurements. | GAO Lei ZHOU Jian SUN ZhiMei CHEN RongShi HAN EnHou | 2011 | Chinese Science Bulletin2011，56，11： | 7 |
| 6 | Prediction of the trajectory of the manned spacecraft SHENZHOU-7 deploying a parachute based on a fine wind field显示文摘Given that horizontal wind plays an important role in predicting the trajectory of the manned spacecraft SHENZHOU-7 when employing a parachute, the China Meteorological Administration conducted an experiment involving high-resolution wind ob servation, analysis and prediction between September 21 and 28, 2008. In this work, an algorithm for tracking a spacecraft de ploying a parachute is studied. High-resolution wind profiles obtained from a numerical weather model, upper-atmosphere soundings and mobile incoherent Doppler wind lidar are compared. Forward and backward trajectory predictions based on various wind profiles, as well as their differences, are presented. In addition, the trajectory of SHENZHOU-7 is predicted using different wind profiles, and the predicted parachute-opening and landing points are compared with the observed points. Results indicate that a high-resolution numerical weather model and fine observation data can offer more-detailed wind information for the prediction of spacecraft trajectories and can thus help in the editing and sending of flight commands, consequently increas ing the accuracy and reliability of landing on an assigned spot and reducing the search area and rescue time. | GUO ZhiMei MIAO QiLong WANG ShuDong LI Huang | 2011 | Science China Earth Sciences2011，54，9： | 5 |
| 7 | Effect of Bag Removing with Reflective Film Mulching Before Harvest on Fruit Coloration and Expression of Anthocyanin Related Genes in Peach显示文摘Appearance quality is the main element forming the fruit quality. Both bagging and reflective film application can improve appearance comprehensive quality. In order to determine the effects of bagging and reflective film on peach fruit coloration, this study explored the effects of applying reflective film before harvest on fruit appearance quality of peach(Prunus persica), and discussed the influencing mechanism on fruit coloration. Yellow outside and black inside double-layer bags were removed from fruit twelve days d before harvest. Peel color, pigment content, enzyme activity as well as the gene expression related to fruit coloration of a well-colored and late-ripening peach cultivar ‘Xiahui 8' with different treatments(non-bagging with non-reflective film mulching, debagging with non-reflective film mulching, debagging with reflective film mulching) were researched. The results showed that both debagging with non-reflective film mulching and debagging with reflective film mulching could significantly improve red and green color difference value(a*), a*/b*(b* is yellow and blue color difference value), chroma(C), anthocyanin(Ant) content and reduce hue angle(h), while debagging with reflective film mulching had higher Ant content than debagging with non-reflective film mulching(P < 0.05). The two treatments up-regulated the transcript level of anthocyanin biosynthetic related genes(UFGT, CHS) at the beginning of the experiment, however, the expression of DFR, LDOX and F3 H were enhanced along with the testing process. A downward trend on peel phenylalanine ammonia lyase(PAL) activity of non-bagging with non-reflective film mulching was observed during the experiment, however, the peel PAL activity of the other two treatments first increased and then decreased. What's more, peel PAL activity of debagging with reflective film mulching was higher than debagging with non-reflective film mulching. These results suggested that Ant synthesis in the peel was the result of cooperation among several genes, and debagging with reflective film mulching had better effect on promoting Ant accumulation than debagging with non-reflective film mulching. | ZHANG Binbin MA Ruijuan ZHANG Chunhua CAI Zhixiang YAN Zhimei | 2015 | Horticultural Plant Journal2015，1，3： | 5 |
| 8 | Vertical characteristics and source identification of PM_(10) in Tianjin显示文摘Ambient PM 10 (particulate matter with a diameter less than 10μm) concentrations were measured on a 255 meter tower in Tianjin,China.The samples were collected at four vertical levels (10,40,120 and 220 m).Vertical characteristics for PM 10 samples were studied.The results showed that the concentrations of PM 10 and constituent species had a negative correlation with the sampling height.The highest concentrations of PM 10 and species were obtained at the 10 m level,and the lowest concentrations were measured at the 220 m level.For the fractions of species to total mass,SO 4 2- and NO 3- had higher values (fraction) at greater height;while Ca had a higher fraction at lower height.Possible source categories for the PM 10 ambient dataset were identified by the principal component analysis method.The possible source categories included crustal dust,vehicles,cement dust,and incineration as well as secondary sulfate and nitrate sources.Analysis of meteorological factors on PM 10 concentrations indicated that wind speed and inversion may be the main factors contributing to different concentrations of PM 10 at different heights. | Zhimei Xiao Jianhui Wu Suqin Han Yufen Zhang Hong Xu Xiaoyong Zhang Guoliang Shi Yinchang Feng | 2012 | Journal of Environmental Sciences2012，24，1： | 5 |
| 9 | Electronic origin of the anomalous solid solution hardening of Y and Gd in Mg:A first-principles study显示文摘Y and Gd demonstrate anomalous solid solution hardening efficiency,which cannot be understood using the elastic impuritydislocation interaction theory.We performed first-principles calculations to investigate the effect of different alloying elements such as Al,Zn,Y,and Gd on the chemical bonding of Mg solid solutions.The present calculations clearly show that the anomalous solid solution hardening of Y and Gd in Mg may be understood based on the increased bonding strength of both Mg-Y (Gd) and Mg-Mg. | GAO Lei ZHOU Jian SUN ZhiMei CHEN RongShi HAN EnHou | 2011 | Chinese Science Bulletin2011，56，10： | 4 |
| 10 | Research Progress of Active Ingredients and Pharmacological Action of Honeysuckle显示文摘Honeysuckle,the dry flower bud or with open flower of Lonicera japonica in caprifoliaceae,has been touted as a cure-all for heat-clearing and detoxifying effect.Honeysuckle contains abundant components such as volatile oil,flavonoids and organic acids,playing the role of antibiosis,antivirus,antiphlogosis,immunopotentiation and antioxidation.The active ingredients and pharmacological action of honeysuckle are reviewed in the paper,so as to lay the foundation for further application of honeysuckle in veterinary clinic. | Zhang Zhimei Guo Shijin Fu Shijun Xu Qianqian Yang Limei Zhang Ying Wang Yanping Ma Li Wang Jianjun Shen Zhiqiang | 2014 | Animal Husbandry and Feed Science2014，6，1： | 4 |
| 11 | Microcystis aeruginosa/Pseudomonas pseudoalcaligenes interaction effects on off-flavors in algae/bacteria co-culture system under different temperatures显示文摘We conducted an experiment to study the interaction effects of Microcystis aeruginosa and Pseudomonas pseudoalcaligenes on off-flavors in an algae/bacteria co-culture system at three temperatures(24, 28 and 32℃). Gas chromatography–mass spectrometry was applied to measure off-flavor compounds dimethyl sulfide(DMS), dimethyl trisulfide(DMTS),2-methylisoborneol, geosmin(GEO) and β-cyclocitral. During the lag phase of co-cultured M. aeruginosa(first 15 days), P. pseudoalcaligenes significantly increased the production of DMS, DMTS and β-cyclocitral at all three temperatures. In the exponential phase of co-cultured M. aeruginosa(after 15 days), M. aeruginosa became the main factor on off-flavors in the co-culture system, and β-cyclocitral turned to the highest off-flavor compound. These results also indicated that DMS, DMTS and β-cyclocitral were the main off-flavor compounds in our M. aeruginosa/P. pseudoalcaligenes co-culture system. Univariate analysis was applied to investigate the effects of M. aeruginosa and P. pseudoalcaligenes on the production of off-flavors. The results demonstrated that both M. aeruginosa and P. pseudoalcaligenes could increase the production of DMS and DMTS, while β-cyclocitral was mainly determined by M. aeruginosa. Our results also provide some insights into understanding the relationship between cyanobacteria and heterotrophic bacteria. | Xi Yang Ping Xie Yunzhen Yu Hong Shen Xuwei Deng Zhimei Ma Peili Wang Min Tao Yuan Niu | 2015 | Journal of Environmental Sciences2015，27，5： | 4 |
| 12 | Label-free Detection of Biotin Using Nanoporous TiO2/DNA Thin-film Coated Wavelength Interrogated Surface Plasmon Resonance Sensors显示文摘 | LI Qiushun HE Hao WANG Junnan ZHENG Hui SHI Jianguo LI Mingyu DONG Wenfei QI Zhimei | 2014 | Chemical Research in Chinese Universities2014，30，1： | 4 |
| 13 | Effect of Phosphorus on Mechanical Properties and Thermal Stability of Fine-grained GH761 Alloy显示文摘The effect of phosphorus on mechanical properties and thermal stability of fine-grained GH761 alloy has been investigated.The results show that,when the content of phosphorus is in the range of 0.0007-0.040,there are no significant effects on the tensile properties.Phosphorus strongly affects the stress rupture life.The content of 0.023 P results in the longest life in this experiment.Compared with that of the alloy with 0.0007 P,the life is increased more than 2 times in the alloy with 0.023 P.After ageing at 700℃ for 1000 h,the life reduced to some extent.However,phosphorus exhibits the similar effect on the life as before ageing.The tensile properties of the alloy are not influenced by long term ageing obviously.The present results suggested that the optimum content of phosphorus is 0.023.The phosphorus with this content can optimize the precipitates at the grain boundaries and prevent the excessive growth of the precipitates.The combining mechanical properties of GH761 alloy can be largely improved by phosphorus addition combined with grain refinement. | Shulin Yang Wenru Sun Jianxi Wang Zhimei Ge Shouren Guo Zhuangqi Hu | 2011 | Journal of Materials Science & Technology2011，27，6： | 3 |
| 14 | Unexpected elastic isotropy in a black phosphorene/TiC2 van der Waals heterostructure with flexible Li-ion battery anode applications显示文摘Recently, flexible electrodes with biaxial/omnidirectional stretchability haveattracted significant attention. However, most existing pliable electrode materialscan be only stretched in one direction. In this work, an unexpected isotropic vander Waals (vdW) heterostructure is proposed, based on the assembly of two-dimensional crystals of anisotropic black phosphorene (BP) and transition metalcarbide (TIC2). Using vdW-corrected density functional theory calculations, theBPFFiC2 vdW heterostructure was predicted to have excellent structural andmechanical stability, superior electrical conductivity, omnidirectional flexibility,and a high Li storage capacity. We have unraveled the physical origin of theexcellent stability, as well as the Li adsorption preferences of the lithiatedheterostructure, based on a three-step analysis of the stability of the Li-adsorptionprocesses. In addition, the BP/TiC2 vdW heterostructure can also be applied asthe anode material for flexible Na-ion batteries because of its high Na storagecapacity and strong Na binding. However, compared with Na adsorption, thecapacity is higher, and the adsorption energy is more negative for Li adsorption.Our findings provide valuable insights into the exploration of a rich variety ofvdW heterostructures for next-generation flexible energy storage devices. | Qiong Peng Kangming Hu Baisheng Sa Jian Zhou Bo Wu Xianhua Hou Zhimei Sun | 2017 | Nano Research2017，10，9： | 3 |
| 15 | Ultrasound measurement of the corpus callosum and neural development of premature infants显示文摘Length and thickness of 152 corpus callosa were measured in neonates within 24 hours of birth.Using ultrasonic diagnostic equipment with a neonatal brain-specific probe,corpus callosum length and thickness of the genu,body,and splenium were measured on the standard mid-sagittal plane,and the anteroposterior diameter of the genu was measured in the coronal plane.Results showed that corpus callosum length as well as thickness of the genu and splenium increased with gestational age and birth weight,while other measures did not.These three factors on the standard mid-sagittal plane are therefore likely to be suitable for real-time evaluation of corpus callosum development in premature infants using cranial ultrasound.Further analysis revealed that thickness of the body and splenium and the anteroposterior diameter of the genu were greater in male infants than in female infants,suggesting that there are sex differences in corpus callosum size during the neonatal period.A second set of measurements were taken from 40 premature infants whose gestational age was 34 weeks or less.Corpus callosum measurements were corrected to a gestational age of 40 weeks,and infants were grouped for analysis depending on the outcome of a neonatal behavioral neurological assessment.Compared with infants with a normal neurological assessment,corpus callosum length and genu and splenium thicknesses were less in those with abnormalities,indicating that corpus callosum growth in premature infants is associated with neurobehavioral development during the early extrauterine stage. | Fang Liu Shikao Cao Jiaoran Liu Zhifang Du Zhimei Guo Changjun Ren | 2013 | Neural Regeneration Research2013，8，26： | 3 |
| 16 | Treatment of Skin Reaction Induced by Nivolumab Combined with Radiotherapy in Non-small Cell Lung Cancer:A Case Report显示文摘Skin reaction or dermatological toxicities induced by immunotherapy is common.It usually manifests skin rash or erythema and can be cured by skin lotion or steroid.Nivolumab,a human IgG4 programmed cell death protein 1(PD-1)inhibitor,blocks T cells activation preventing signal and allows the immune system to clear cancer cells.Nivolumab was approved in the second-line therapy in squamous cell lung cancer by FDA,with less than 10%unusual skin reaction,like sensory neuropathy,peeling skin,erythema multiforme,vitiligo,and psoriasis.Radiotherapy could aggravate this skin reaction through inflammatory response and promotion of immunity.The combined treatment of anti-PD-1 and radiotherapy represented a new promising therapeutic approach in many studies,but the risk of side effects may be high.We reported a patient with advanced squamous cell lung cancer who suffered from serious skin immune-related adverse events when he was treated with nivolumab and radiotherapy.The immune overreaction of the treatment of anti-PD-1 treatment and radiotherapy might cause these serious skin adverse events.Our report warranted careful workup to reduce the risk of side effects by combinative therapy with anti-PD-1 and radiotherapy. | Zhimei Zhao Shichao Liu Xiajuan Xu Zhongfa Zhang Keke Nie Youxin Ji | 2018 | Chinese Medical Sciences Journal2018，33，3： | 3 |
| 17 | Prediction of thermoelectric performance for layered IV-V-VI semiconductors by high-throughput ab initio calculations and machine learning显示文摘Layered IV-V-VI semiconductors have immense potential for thermoelectric(TE)applications due to their intrinsically ultralow lattice thermal conductivity.However,it is extremely difficult to assess their TE performance via experimental trial-and-error methods.Here,we present a machine-learning-based approach to accelerate the discovery of promising thermoelectric candidates in this chalcogenide family.Based on a dataset generated from high-throughput ab initio calculations,we develop two highly accurateand-efficient neural network models to predict the maximum ZT(ZT_(max))and corresponding doping type,respectively.The top candidate,n-type Pb_(2)Sb_(2)S_(5),is successfully identified,with the ZT_(max) over 1.0 at 650 K,owing to its ultralow thermal conductivity and decent power factor.Besides,we find that n-type Te-based compounds exhibit a combination of high Seebeck coefficient and electrical conductivity,thereby leading to better TE performance under electron doping than hole doping.Whereas p-type TE performance of Se-based semiconductors is superior to n-type,resulting from large Seebeck coefficient induced by high density-ofstates near valence band edges. | Yu Gan Guanjie Wang Jian Zhou Zhimei Sun | 2021 | npj Computational Materials2021，，1： | 3 |
| 18 | The microbial metallogeny of weathering crust REE deposits in South China显示文摘VERY little is known about the roles of microorganisms in the metallogeny of weathering crust REE deposits, although there has been much literature on REE behavior in weathering conditions. The present note deals with the microorganisms in 4 weathering profiles of an REE deposit and their roles in migration and accumulation of REE in weathering conditions. 1 Cultivation and identification of microorganisms Under strict sterilization, samples were collected from various parts of 4 weathering profiles of granites in a weathering crust REE deposit in South China. The samples were then cultivated for microorganisms with ordinary agars as culture media and then the cultivated microorganisms were dyed and identifiedunder a microscope. The sampled positions and cultivated numbers of microbial colonies are shown | CHEN Binghui~(1,2), WANG Zhimei~3, HUANG Limei~3, WU Fuhai~3, CHEN Jingde~2 and XU Wenlie~2 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth Sciences, Zhongshan University, Guangzhou 510275, China 3. Guangdong Pharmaceutical College, Guangzhou 510244, China | 1999 | Chinese Science Bulletin1999，44，S2： | 3 |
| 19 | Acid-degradable gadolinium-based nanoscale coordination polymer: A potential platform for targeted drug delivery and potential magnetic resonance imaging显示文摘在为癌症的常规化疗期间, nonspecific 药分发,在正常纸巾引起严肃的副作用,是严肃的限制。因此,得一个肿瘤或细胞内部的微型环境应答的 nanosystem 为是合乎需要的指向并且按需的药版本。在现在的学习,我们设计了聪明的 pH-activatable nanosystem, gadolinium-doxorubicin-loaded nanoscale 协作聚合物(Gd 纪录影片 NCP ) 在是核心,玻尿的酸是指向的壳。利用 CD44 调停受体的识别, nanoparticles 有选择地被使内在化进人的颈的癌(HeLa ) 房间,并且在纪录影片的荧光恢复了的酸的分隔空间以内套住与 Gd NCP 拆除的酸一起,允许药版本的即时监视。在 vitro,实验也证明在场的 Gd NCP 在被触发酸的降级以后提高了 T 1 信号,建议他们象为磁性的回声成像的对比代理人的潜在的使用。如此的 nanocarriers,展示高 biodegradation,选择指向能力,和对刺激的快速的反应,在指向的癌症房间表明了提高的治疗学的功效并且在 vitro 打开了 T 1 信号,显示出为诊断和治疗的大诺言。 | Zhimei He Penghui Zhang Yan Xiao Jingjing Li Fang Yang Yang Liu Jian-Rong Zhang Jun-Jie Zhu | 2018 | Nano Research2018，11，2： | 3 |
| 20 | The clinical and genetic characteristics in children with mitochondrial disease in China显示文摘Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of children with mitochondrial disease in China. We tested 141 candidate patients who have been suspected of mitochondrial disorders by using targeted next-generation sequencing(NGS), and summarized the clinical and genetic data of gene confirmed cases from Neurology Department, Beijing Children's Hospital, Capital Medical University from October 2012 to January 2015. In our study, 40 cases of gene confirmed mitochondrial disease including eight kinds of mitochondrial disease, among which Leigh syndrome was identified to be the most common type, followed by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes(MELAS). The age-of-onset varies among mitochondrial disease, but early onset was common. All of 40 cases were gene confirmed, among which 25 cases(62.5%)with mitochondrial DNA(mtDNA) mutation, and 15 cases(37.5%) with nuclear DNA(nDNA) mutation. M.3243A>G(n=7)accounts for a large proportion of mtDNA mutation. The nDNA mutations include SURF1(n=7),PDHA1(n=2),and NDUFV1,NDUFAF6, SUCLA2, SUCLG1, RRM2 B, and C12orf65, respectively. | Fang Fang Zhimei Liu Hezhi Fang Jian Wu Danmin Shen Suzhen Sun Changhong Ding Tongli Han Yun Wu Junlan Lv Lei Yang Shufang Li Jianxin Lv Ying Shen | 2017 | Science China(Life Sciences)2017，60，7： | 2 |
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