| 1 | Cloning and characterization of human IC53-2,a novel CDK5 activator binding protein显示文摘We have identified IC53-2, a human homologue of the rat C53 gene from a human placenta cDNA library (GeneBank Accession No. AF217982). IC53-2 can bind to the CDK5 activator p35 by in vitro association assay. IC53-2 is mapped to human chromosome 17q21.31. The IC53-2 transcript is highly expressed in kidney, liver, skeletal muscle and placenta. It is abundantly expressed in SMMC-7721, C-33A, 3AO, A431and MCF-7 cancer cell lines by RT-PCR assay. Stable transfection of IC53-2 cDNA into the hepatocellularcarcinoma SMMC-7721 cell remarkably stimulates its growth in vitro. The above results indicate thatIC53-2 is a novel human gene, which may be involved in the regulation of cell proliferation. | YIHUXIE XIANGHUOHE YUNTIANTANG JINJUNLI ZHIMEIPAN WENXINQIN DAFANGWAN JIANRENGU | 2003 | Cell Research2003，13，2： | 1 |
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