4篇
您的检索式：作者名="ZHOU Shanrong"
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| 1 | Identification of portal vein tumor thrombus with an independent clonal origin in hepatocellular carcinoma via multi-omics data analysis显示文摘Objective: Multiple mechanisms underlying the development of portal vein tumor thrombus(PVTT) in hepatocellular carcinoma(HCC) have been reported recently. However, the origins of PVTT remain unknown. Increasing multi-omics data on PVTTs in HCCs have made it possible to investigate whether PVTTs originate from the corresponding primary tumors(Ts).Methods: The clonal relationship between PVTTs and their corresponding primary Ts was investigated using datasets deposited in public databases. One DNA copy number variations dataset and three gene expression datasets were downloaded for the analyses.Clonality analysis was performed to investigate the clonal relationship between PVTTs and Ts from an individual patient.Differential gene expression analysis was applied to investigate the gene expression profiles of PVTTs and Ts.Results: One out of 19 PVTTs had no clonal relationship with its corresponding T, whereas the others did. The PVTTs with independent clonal origin showed different gene expression and enrichment in biological processes from the primary Ts. Based on the unique gene expression profiles, a gene signature including 24 genes was used to identify pairs of PVTTs and primary Ts without any clonal relationship. Validation in three datasets showed that these types of pairs of PVTTs and Ts can be identified by the 24-gene signature.Conclusions: Our findings show a direct evidence for PVTT origin and consolidate the heterogeneity of PVTTs observed in clinic.The results suggest that PVTT investigation at a molecular level is clinically necessary for diagnosis and treatment. | Shupeng Liu Zaixin Zhou Yin Jia Jie Xue Zhiyong Liu Kai Cheng Shuqun Cheng Shanrong Liu | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 2 | Thermal expansivity of geikielite and ilmenite utilizing in-situ synchrotron X-ray diffraction at high temperature显示文摘The unit-cell parameters and volumes of geikielite(MgTiO_(3))and ilmenite(FeTiO_(3))were investigated at high temperatures up to 700 K and ambient pressure,using in-situ angle-dispersive synchrotron X-ray diffraction.No phase transition was detected over the experimental temperature range.Using(Berman in J Petrol29:445-522,1988.10.1093/petrology/29.2.445)equations to fit the temperature-volume data,the volumetric thermal expansion coefficients at ambient conditions(α_(V0))of MgTiO_(3) and FeTiO_(3) were obtained as follows:2.55(6)×10^(-5)K^(-1)and 2.82(10)×10^(-5)K^(-1),respectively.We infer that the larger effective ionic radius of Fe^(2+)(Ⅵ)(0.78 A)than that of Mg^(2+)(Ⅵ)(0.72?)renders FeTiO_(3)has a larger volumetric thermal expansivity than MgTiO_(3).Simultaneously,the refined axial thermal expansion coefficients under ambient conditions areα_(a0)=0.74(3)×10^(-5)K^(-1)andα_(c0)=1.08(5)×10^(-5)K^(-1)for the aaxis and c-axis of MgTiO_(3),respectively,andα_(a0)=0.95(5)×10^(-5)K^(-1)andα_(c0)=0.92(12)×10^(-5)K^(-1)for the aaxis and c-axis of FeTiO_(3),respectively.The axial thermal expansivity of MgTiO_(3) is anisotropic,but that of FeTiO_(3) is nearly isotropic.We infer that the main reason for the different axial thermal expansivity between MgTiO_(3) and FeTiO_(3) is that the thermal expansion mode of the Mg-O bond in MgTiO_(3) is different from that of the Fe-O bonds in FeTiO_(3). | Jiamei Song Dawei Fan Shijie Huang Shanrong Zhang Mengzeng Wu Wei Chen Wenge Zhou | 2023 | Acta Geochimica2023，42，6： | 0 |
| 3 | Brief History of Painting in Modern China显示文摘Dianshizhai Pictorial,originated in 1884,is the first pictorial of news and current affairs in China’s modern history.Its elegant and prevailing expression forms greatly broadened the audience range of the publication and became an important graphic material for studying the transformation of social life in the late Qing Dynasty of China.This paper claims to give a brief account of the“history of painting”in modern China and provides a spacious research perspective for the above studies. | ZHANG Pei CHEN Huiping ZHOU Shanrong | 2022 | Cultural and Religious Studies2022，10，5： | 0 |
| 4 | Exploration on the Future Development Path of Chinese Podcast显示文摘When Chinese podcast experienced a short period of rapid development in the first year and entered the“cooling-off period”,there are so many new exposed problems that need to be solved.In this paper,the author will explore the problems existing in the current development of Chinese podcast from six macro perspectives,as well as the possible trend of future podcast development. | ZHANG Pei XIONG Kunyao ZHOU Shanrong | 2022 | Cultural and Religious Studies2022，10，5： | 0 |
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