|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国糖尿病发病率和检出率地域性差异——98058例成年受试者数据多水平空间分析显示文摘目的探究中国糖尿病发病率和检出率地域性差异。方法选取分布在中国大陆162个地区的98058例18岁以上成年受试者的自述报告和生物学数据(90.5%反馈率),采用美国糖尿病协会糖尿病诊疗标准评估受试者的糖尿病症状,根据先前诊断结果 ,做出其是否患有糖尿病的判断。以各省为单位,使用分区统计图表法评估各调研数据结果的地域性差异。应用多元logistic回归分析法,校正个体和地域层级的差别后,评估每个结果出现的概率。结果各省糖尿病患者的地理分布反映出中国糖尿病发病率和检出率地域性差异。校正年龄、性别和城市/农村社会经济状况等因素后,糖尿病发病率自东北部向北部,从8.3%(95%CI 7.2%,9.7%)上升至12.7%(11.1%,14.6%)。从较好社会经济状况(socioeconomic circumstances,SEC)的城市到农村较差社会经济状况的县/区,糖尿病发病率呈下降趋势,分别为13.1%(12.0%,14.4%)和8.7%(7.8%,9.6%)。校正健康知识水平和个人原因两个因素后,地域性差异仍具有统计学意义。仅三分之一的糖尿病患者在接受此次测试前有糖尿病诊断史,但此结果因地域不同而不同。校正年龄、性别和城市/农村SEC后,糖尿病检出率自北向西南从40.4%(34.9%,46.3%)下降至15.6%(11.7%,20.5%)。与较好SEC县市的40.8%(37.3%,44.4%)检出率相比,农村较差SEC地区的检出率最低,仅为20.5%(17.7%,23.7%)。糖尿病检出率的地域性差异并不完全是个体差异造成的。结论加强防控糖尿病意识,提高检测准确率应从地域性因素出发。 | 陈研 陈刚 Maigeng Zhou Thomas Astell-Burt Yufang Bi | 2015 | 创伤与急诊电子杂志2015，3，4： | 42 |
| 2 | The secretion profile of mesenchymal stem cells and potential applications in treating human diseases显示文摘Mesenchymal stromal/stem cells(MSCs)possess multi-lineage differentiation and self-renewal potentials.MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases,due to the potent immunoregulatory functions of MSCs.An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions.Growth factors,cytokines,chemokines,extracellular matrix components,and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.These secretory factors contribute to immune modulation,tissue remodeling,and cellular homeostasis during regeneration.In this review,we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. | Yuyi Han Jianxin Yang Jiankai Fang Yipeng Zhou Eleonora Candi Jihong Wang Dong Hua Changshun Shao Yufang Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 6 |
| 3 | Detail control strategies for topology optimization in architectural design and development显示文摘With the ability to generate forms with high efficiency and elegant geometry,topology optimization has been increasingly used in architectural and structural designs.However,the conventional topology optimization techniques aim at achieving the structurally most efficient solution without any potential for architects or designers to control the design details.This paper introduces three strategies based on Bi-directional Evolutionary Structural Optimization(BESO)method to artificially pre-design the topological optimized structures.These strategies have been successfully applied in the computational morphogenesis of various structures for solving practical design problems.The results demonstrate that the developed methodology can provide the designer with structurally efficient and topologically different solutions according to their proposed designs with multi-filter radii,multi-volume fractions,and multi-weighting coefficients.This work establishes a general approach to integrating objective topology optimization methods with subjective human design preferences,which has great potential for practical applications in architecture and engineering industry. | Xin Yan Dingwen Bao Yufang Zhou Yimin Xie Tong Cui | 2022 | Frontiers of Architectural Research2022，11，2： | 4 |
| 4 | Coupled relationships among anammox,denitrification, and dissimilatory nitrate reduction to ammonium along salinity gradients in a Chinese estuarine wetland显示文摘Salinization in estuarine wetlands significantly alters the balance between their nitrogen(N)removal and retention abilities but these processes have not yet been characterized effectively.In the present study,the potential rates of sediment denitrification,anaerobic ammonium oxidation(anammox),and dissimilatory nitrate reduction to ammonium(DNRA)were mapped using N isotope tracing methods along salinity gradients across the Yellow River Delta wetland(YRDW)in China.The contribution of anammox to total dissimilatory N transformations in YRDW was merely 6.8%,whereas denitrification and DNRA contributed 52.3%and 40.9%,respectively.The potential rate of denitrification(5.82μmol/kg/h)decreased significantly along salinity gradients and markedly exceeded DNRA potential rate(2.7μmol/kg/h)in fresh wetlands,but was lower than that of DNRA in oligohaline wetlands(3.06 and 3.18μmol/kg/h,respectively).Moreover,a significantly positive relationship between salinity and DNRA/denitrification was obeserved,indicating that increased salinity may favor DNRA over denitrification.Furthermore,total sulfur(TS)content and ratio of total organic carbon to total nitrogen(C/N)increased with the salinity gradient and showed evident positive relationships with the DNRA/denitrification ratio.In this study,we proved that increased salinization resulted in the dominance of DNRA over denitrification,possible through the addition of S and alteration of the C/N in estuarine wetlands,leading to increased N retention in estuarine wetlands during salinization,which would enhance the eutrophication potential within wetlands and in downstream ecosystems. | Zijun Zhou Lei Ge Yufang Huang Yuqian Liu Siyang Wang | 2021 | Journal of Environmental Sciences2021，33，8： | 4 |
| 5 | Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma显示文摘Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs(linc RNAs) play in diverse cellular processes, our knowledge of how linc RNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of linc RNAs.Consistent with previous findings of co-expression between neighboring protein-coding genes, linc RNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of linc RNAs termed 'regulatory linc RNAs', representing their dominant roles in gene regulation. The number of regulatory linc RNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory linc RNA,GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory linc RNAs with inclusion of some cancer-associated linc RNAs. Our integrated analysis reveals enhanced regulatory effects of linc RNAs and provides a resource for the study of regulatory linc RNAs that play critical roles in lung adenocarcinoma. | You Zhou Kai Wu Jianping Jiang Jinfei Huang Peiwei Zhang Yufei Zhu Guohong Hu Jingyu Lang Yufang Shi Landian Hu Tao Huang Xiangyin Kong | 2015 | Journal of Genetics and Genomics2015，42，8： | 3 |
| 6 | N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA显示文摘Background:N-acetyltransferase 10(NAT10)is the only enzyme known tomediate the N4-acetylcytidine(ac4C)modification of mRNA and is crucial formRNA stability and translation efficiency.However,its role in cancer development and prognosis has not yet been explored.This study aimed to examine the possible role of NAT10 in colon cancer.Methods:The expression levels ofNAT10were evaluated by immunohistochemical analyses with a colon cancer tissue microarray,and its prognostic value in patients was further analyzed.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blotting were performed to analyze NAT10 expression in harvested colon cancer tissues and cell lines.Stable NAT10-knockdown and NAT10-overexpressing colon cancer cell lines were constructed using lentivirus.The biological functions of NAT10 in colon cancer cell lines were analyzed in vitro by Cell Counting Kit-8(CCK-8),wound healing,Transwell,cell cycle,and ferroptosis assays.Xenograft models were used to analyze the effect of NAT10 on the tumorigenesis and metastasis of colon cancer cells in vivo.Dot blotting,acetylated RNA immunoprecipitation-qPCR,and RNA stability analyses were performed to explore the mechanism by which NAT10 functions in colon cancer progression.Results:NAT10 was upregulated in colon cancer tissues and various colon cancer cell lines.This increased NAT10 expression was associated with shorter patient survival.Knockdown of NAT10 in two colon cancer cell lines(HT-29 and LoVo)impaired the proliferation,migration,invasion,tumor formation and metastasis of these cells,whereas overexpression of NAT10 promoted these abilities.Further analysis revealed that NAT10 exerted a strong effect on the mRNA stability and expression of ferroptosis suppressor protein 1(FSP1)in HT-29 and LoVo cells.In these cells,FSP1 mRNA was found to be modified by ac4C acetylation,and this epigenetic modification was associated with the inhibition of ferroptosis.Conclusions:Our study revealed that NAT10 plays a critical role in colon cancer development by affecting FSP1 mRNA stability and ferroptosis,suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer. | Xiao Zheng Qi Wang You Zhou Dachuan Zhang Yiting Geng Wenwei Hu Changping Wu Yufang Shi Jingting Jiang | 2022 | Cancer Communications2022，42，12： | 3 |
| 7 | TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis ina Chinese population显示文摘 | YuFang Lu Zhang Gang-qiao Zhou Zhi-fu Wang Kai Feng Zhi-yi Lou Wei Pang Lei Li Yan Ling Yu-xia Li Bao-chi Liu | 2010 | World Journal of Emergency Medicine2010，1，3： | 3 |
| 8 | HbA1c and the diagnosis of diabetes and prediabetes in a middle‐aged and elderly H an population from northwest C hina (HbA1c与中国西北部地区中老年汉族人群糖尿病和糖尿病前期的诊断)显示文摘 | Shengli Wu Fengshou Yi Chao Zhou Mintao Zhang Yujing Zhu Yilihamu Tuniyazi Lijuan Huang Xuefang Huang Fugang Wang Yufang Bi Guang Ning | 2013 | Journal of Diabetes2013，，： | 1 |
| 9 | Genetic and Epigenetic Down-regulation of MicroRNA-212 Promotes Colorectal Tumor Metastasis via Dysregulation of MnSOD显示文摘 | Xiangqi Meng Jiangxue Wu Changchuan Pan Hui Wang Xiaofang Ying Yi Zhou Hongyan Yu Yufang Zuo Zhizhong Pan Ran–Yi Liu Wenlin Huang | 2013 | Gastroenterology2013，，2： | 1 |
| 10 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 11 | Latest Progress and Trend Forecast of China’s Shale Gas Exploration and Development显示文摘1 Introduction With almost five years of efforts,we have made major breakthrough and important advances in shale gas in many areas,such as the marine and continental shale in Sichuan Basin,the continental shale in Erdos Basin and the transitional shale in North China.China has begun shale gas productivity constructions in many shale | WANG Yufang ZHAI Gangyi BAO Shujing REN Shoumai GE Mingna ZHOU Zhi | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 12 | Highly selective oxidation of amines to imines by Mn2O3 catalyst under eco-friendly conditions显示文摘Enhancing the selectivity of imines for the oxidative self-coupling of primary amines was found to be challenging in the heterogeneous catalysis.Three different manganese oxides(M-3,M-4,M-5) were synthesized by controlling the calcination temperature using a simple template-free oxalate route.The prepared manganese oxides were systematically characterized using XRD,N2 sorption,SEM,TEM,XPS,H2-TPR techniques.M-4 gave 96.2% selectivity of imine at 100% conversion of benzylamine,which was far more superior than other existing protocols.Mn^3+/Mn^4+ ratio was found to affect the selectivity of the imines.The probable reaction pathway for amines oxidation catalyzed by manganese oxides was proposed for the first time. | Fushan Chen Tao Yang Songlin Zhao Taotao Jiang Lu Yu Houfeng Xiong Chuankun Guo Yufang Rao Yan Liu Liu Liu Jian Zhou Pengxiang Tu Jun Ni Qunfeng Zhang Xiaonian Li | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 13 | HbAlc and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (I-lbA1 )显示文摘 | Shengli Wu Fengshou i Chao Zhou Mintao Zhang Yujing Zhu Yilihamu Tuniyazi Lijuan Huang Xuefang Huang Fugang Wang Yufang Bi Guang Ning | 2013 | Journal of diabetes2013，5，3： | 1 |
| 14 | Preparation and ap- plication of melanmine formaldehyde pootoehromie microeapsules 显示文摘 | Zhou Yuehua Yan Yufang Du Yang et td | 2013 | Sens~ rs and Act uators B : Chemk''al2013，188，： | 1 |
| 15 | A fluorometric assay for acetylcholinesterase activity and inhibitor detection based on DNA-templated copper/silver nanoclusters显示文摘 | Wenhua Li Wang Li Yufang Hu Yalin Xia Qinpeng Shen Zhou Nie Yan Huang Shouzhuo Yao | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 16 | 3D printing of conch-like scaffolds for guiding cell migration and directional bone growth显示文摘Regeneration of severe bone defects remains an enormous challenge in clinic.Developing regenerative scaffolds to directionally guide bone growth is a potential strategy to overcome this hurdle.Conch,an interesting creature widely spreading in ocean,has tough spiral shell that can continuously grow along the spiral direction.Herein,inspired by the physiological features of conches,a conch-like(CL)scaffold based onβ-TCP bioceramic material was successfully prepared for guiding directional bone growth via digital light processing(DLP)-based 3D printing.Benefiting from the spiral structure,the CL scaffolds significantly improved cell adhesion,proliferation and osteogenic differentiation in vitro compared to the conventional 3D scaffolds.Particularly,the spiral structure in the scaffolds could efficiently induce cells to migrate from the bottom to the top of the scaffolds,which was like“cells climbing stairs”.Furthermore,the capability of guiding directional bone growth for the CL scaffolds was demonstrated by a special half-embedded femoral defects model in rabbits.The new bone tissue could consecutively grow into the protruded part of the scaffolds along the spiral cavities.This work provides a promising strategy to construct biomimetic biomaterials for guiding directional bone tissue growth,which offers a new treatment concept for severe bone defects,and even limb regeneration. | Boshi Feng Meng Zhang Chen Qin Dong Zhai Yufeng Wang Yanling Zhou Jiang Chang Yufang Zhu Chengtie Wu | 2023 | Bioactive Materials2023，，4： | 1 |
| 17 | Ecotoxicity of soils contaminated with industrial and domestic wastewater in western Shenyang, China显示文摘Soil samples were collected from 7 sites in the up-, mid- and down-reach along and nearby the wastewater irrigation channel, western Shenyang of China. The concentrations of selected pollutants (mineral oil, PAHs - polycycle aromatic hydrocarbons and Cd) were determined by UV spectrometer, HPLC and AAS (atomic adsorption spectrometer) spectrometer, respectively. Toxicity effects of soils were evaluated by seedling emergence test with root length of wheat as the end-point and by earthworms test with the mortality rate and inhibition rates of body weight as endpoints. Results showed accumulation of pollutants for most soils with concentration of 200.2 mg.kg-1 ~1600 mg.kg-1 for mineral oil, 0.33 mg.kg-1~1.81 mg.kg-1 for Cd and 900.16 mg.kg-1~ 2737.91 mg.kg-1 for PAHs. The inhibition rates of root elongation were from -20% up to 40 %, and mortality rates of earthworms ranged from 0%~40% from the exposure period of two weeks to eight weeks by sampling interval of two weeks, the inhibition rates of earthworm growth were from -19.36% to 34.53%, showing effects of stimulation at 2 weeks to an increasing effects of inhibition at 4, 6 and 8 weeks, respectively. Mortality rates correlated with the loss of body weight of earthworms.This study indicated the potential risk of pollutants of environmental low content in soil by the determination of selected chemicals combined with toxicity indexes. | SONG Yufang, ZHOU Qixing, GONG Ping & SUN Tieheng Key Laboratory of Terrestrial Ecological Processes, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Analytical Services, Inc., 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, USA Key Laboratory of Environmental Engineering of Shenyang, Shenyang University, Shenyang 110041, China | 2005 | Science China(Life Sciences)2005，48，z1： | 1 |
| 18 | Association between plasma ho- moeysteine status and hypothyroidism: a meta-analysis显示文摘 | Yande Zhou Yufang Chen | 2014 | Int J Clin Exp Med2014，7，11： | 1 |
| 19 | Genetic and Epigenetic Down-regulation of MicroRNA-212 Promotes Colorectal Tumor Metastasis via Dysregulation of MnSOD显示文摘 | Xiangqi Meng Jiangxue Wu Changchuan Pan Hui Wang Xiaofang Ying Yi Zhou Hongyan Yu Yufang Zuo Zhizhong Pan Ran–Yi Liu Wenlin Huang | 2013 | Gastroenterology2013，，2： | 1 |
| 20 | Geographical Variation in Diabetes Prevalence and Detection in China:Multilevel Spatial Analysis of 98,058 Adults显示文摘 | Maigeng Zhou Thomas Astell-Burt Yufang Bi | 2015 | Diabetes Care2015，38，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员