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您的检索式：作者名="ZHOU Zhining"
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| 1 | Paralog-divergent Features May Help Reduce Off-target Effects of Drugs:Hints from Glucagon Subfamily Analysis显示文摘Side effects from targeted drugs remain a serious concern. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which are highly homologous in sequences and have similar structures and drug-binding pockets. To identify targetable differences between paralogs, we analyzed two types(type-I and type-II) of functional divergence between two paralogs in the known target protein receptor family G-protein coupled receptors(GPCRs) at the amino acid level. Paralogous protein receptors in glucagon-like subfamily, glucagon receptor(GCGR) and glucagon-like peptide-1 receptor(GLP-1R), exhibit divergence in ligands and are clinically validated drug targets for type 2 diabetes. Our data showed that type-II amino acids were significantly enriched in the binding sites of antagonist MK-0893 to GCGR, which had a radical shift in physicochemical properties between GCGR and GLP-1R. We also examined the role of type-I amino acids between GCGR and GLP-1R. The divergent features between GCGR and GLP-1R paralogs may be helpful in their discrimination, thus enabling the identification of binding sites to reduce undesirable side effects and increase the target specificity of drugs. | Zhining Sa Jingqi Zhou Yangyun Zou Zhixi Su Xun Gu | 2017 | Genomics, Proteomics & Bioinformatics2017，15，4： | 0 |
| 2 | Generating Functional for Truncated Green Functions and an Application to Scattering Matrix显示文摘The generating functional for truncated Green functions which is lacking in the field theories,is introduced for the spinor electrodynamics.Such generating functional is shown to be excellent in expressing the scattering matrix and used to construct a formula for the latter.The method is also applicable in principle to other field theories. | ZHOU Zhining ZHONG Yushu LI Xianhui | 1995 | Chinese Physics Letters1995，12，1： | 0 |
| 3 | Layer by Layer Assembly of Poly(Allylamine Hydrochloride)/Phosphate Ions and Poly(Sodium 4-Styrene Sulfonate) Membrane for Forward Osmosis Application显示文摘Based on the layer by layer(Lb L)assembly technology,the nano-scale composite membrane with excellent structure can be prepared by changing the polyelectrolyte and controlling the deposition conditions.Polyamines and phosphate ions(Pi)can be self-organized to form supramolecular systems which could be exploited to stabilize the interfacial architecture.The LbL membrane was made of the positively charged poly(allylamine hydrochloride)(PAH)self-organized with Pi and the negatively charged poly(sodium 4-styrene sulfonate)(PSS)alternatively on top of a poly(acrylonitrile)(PAN)substrate.Compared to the membrane without Pi,the membrane assembled by PAH/Pi improved forward of flux and reduced flux of salt.The concentration of PAH and PSS,deposition time,pH and number of layers showed significant influences on the performance of the membrane.In this experiment,we systematically investigated the preparation conditions and under the optimized conditions the prepared membrane exhibited high water fluxes of 13.5 L m^-2 h^-1 with corresponding salt to water flux,Js/Jv,ratio of 0.07 g L^-1 tested by forward osmosis when DI water as feed solution and 2 mol L^-1 MgCl2 as draw solution. | ZHOU Wen YU Li LI Yiming GAO Baoyu WANG Zhining | 2019 | Journal of Ocean University of China2019，18，3： | 0 |
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