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| 1 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 2 | A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells显示文摘Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC). | Liheng Yang Yan Zhang Lipeng Hu Ying Zhu Man-Sun Sy Chaoyang Li | 2014 | Virologica Sinica2014，29，4： | 3 |
| 3 | Effect of disodium fumarate on in vitro rumen fermentation of different substrates and rumen bacterial communities as revealed by denaturing gradient gel electrophoresis analysis of 16S ribosomal DNA显示文摘 | Mao SY Zhang G Zhu WY | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 4 | A Study on the Reaction Mechanism of Bromocresol Green with Bovine Serum Albumin显示文摘AStudyontheReactionMechanismofBromocresolGreenwithBovineSerumAlbuminKenZhu;KeAnLI;ShenYangTONG(ChemistryDepartment,PekingUniv... | Zhu, K Li, KA Tong, SY | 1996 | Chinese Chemical Letters1996，7，11： | 2 |
| 5 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 6 | Case-deletion measures for models with incomplete data显示文摘 | Zhu HT Lee SY Wei BC Zhu J | 2001 | Biometrika2001，88，： | 1 |
| 7 | Local influence for generalized linear mixed models显示文摘 | Zhu HT Lee SY | 2003 | The Canadian Journal of statistics2003，31，： | 1 |
| 8 | SYBR Green-based real-time PCR assay for detection of VKORC1 and CYP2C9 polyrnor phisms that modulate warfarin dose requirement显示文摘 | Huang SW Li Q Zhu SY | 2009 | Clin Chem Lab Med2009，47，1： | 1 |
| 9 | Coincident wire and powder deposition by laser to form compositionally graded material 显示文摘 | Waheed UI Haq Syed Andrew J Pinkerton Zhu Liu | 2007 | Surface and Coating Technology2007，201，16： | 1 |
| 10 | A homogenous nature of n- ative Chinese duck matrilineal pool 显示文摘 | He DQ Zhu Q Chen SY | 2008 | BMC Evolutionary Biology2008，8，1： | 1 |
| 11 | Orally administered den- drobium officinale and its polysaccharides enhance immune functions in BALB/c mice显示文摘 | Liu XF Zhu J 6e SY | 2011 | Nat Prod Commun2011，6，6： | 1 |
| 12 | Development of a monoclonal antibody-based broad-specificity ELISA for fluoro- quinolone antibiotics in foods and molecular modeling studies of cross-reactive compounds显示文摘 | Wang ZH Zhu Y Ding SY | 2007 | Anal Chem2007，79，12： | 1 |
| 13 | Establishment of a human acute promyelocytic leukemia-ascites model in SCID mice显示文摘 | Zhang SY Zhu J Chen GQ | 1996 | Blood1996，87，8： | 1 |
| 14 | Prevalence of amblyopia and strabismus in a population of 7th-grade junior high school students in Central China: the Anyang Childhood Eye Study ( ACES)显示文摘 | Fu J u SM Liu LR u JL Li SY Zhu BD | 2014 | Ophthalmic Epidemiol2014，21，3： | 1 |
| 15 | Solid-state anaerobic digestion for methane production from organic waste显示文摘 | Li Y Park SY Zhu J | 2011 | Renewable and Sustainable Energy Reviews2011，15，： | 1 |
| 16 | Effects of 17β-estradiol and phytoestrogen α-zearalanol on tissue factor in ovariectomized rats and endothelial cells显示文摘 | Wang W Zhu GJ Zu SY | 2004 | Chinese J Physiol2004，47，2： | 1 |
| 17 | Mutational spectrum of phenylketonuria in the Chinese Han population:a novel insight into the geographic distribution of the common mutations显示文摘 | Zhu TW Qin SY Ye J | | 0，，： | 1 |
| 18 | High-frequency sonographic meas- urements of true and false vocal cords 显示文摘 | Hu Q Zhu SY Luo F | 2010 | J Ultrasound Med2010，29，7： | 1 |
| 19 | Nausea and vomiting after transcatheter arterial chemoembolization for hepatocellular carci- noma:incidence and risk {actor analysis显示文摘 | Wang SY Zhu WH Vargulick S | 2013 | Asian Pae J Cancer Prey2013，14，10： | 1 |
| 20 | Mutational spectrum of phenylketorLuria in the Chinese Han population: a novel insight into the geographic distribution of the common mutations显示文摘 | Zhu TW Qin SY Ye J | 2010 | Pediatr Res2010，67，3： | 1 |
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