| 2 | Efficacy of Danggui Buxue decoction(当归补血汤)on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism显示文摘OBJECTIVE:To observe the efficacy of Danggui Buxue decoction(当归补血汤,DBD) on diabetic nephropathyinduced renal fibrosis in rats,and to study the possible mechanism.METHODS:Sixty male Goto Kakizaki(GK) rats were randomly assigned to the model group,gliquidone group,astragaloside Ⅳ group,and high-,medium-and lowdoses DBD groups.After 8 weeks,changes in body weight,blood glucose,serum creatinine,serum urea nitrogen,and total cholesterol were observed.Changes in transforming growth factor-β1(TGF-β1),Smad3,and Smad5 pathways and the expression of the fibrosisrelated proteins collagen Ⅳ(col Ⅳ),α-smooth muscle actin(α-SMA),and vimentin were assessed.The degree of renal fibrosis was observed by immunohistochemistry and Mason staining.The expression of interleukin 6(IL-6),interleukin 10(IL-10),tumor necrosis factor(TNF-α),and C-reactive protein(CRP) in the kidneys was assessed using enzyme linked immunosorbent assay.RESULTS:Our experiments showed that DBD effectively reduced blood glucose,blood urea nitrogen,and creatinine levels after 8 weeks of administration,improved renal function in diabetic rats,alleviated renal fibrosis,and reduced the renal tissue levels of IL-6,IL-10,TNF-α,and CRP.Furthermore,DBD decreased the expression of TGF-β1,Smad3,col IV,α-SMA,and vimentin in renal tissues and increased the expression of Smad5.CONCLUSIONS:DBD ameliorates diabetic renal interstitial fibrosis by modulating the TGF-β1/Smads pathway. | ZHAO Ye WANG Xian GU Ling LI Zihang ZHU Jingtian WANG Wenkai ZHANG Liang XUE Mei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 4 | Electronic Orbital Alignment and Hierarchical Phonon Scattering Enabling High Thermoelectric Performance p-Type Mg_(3)Sb_(2) Zintl Compounds显示文摘Environmentally friendly Mg_(3)Sb_(2)-based materials have drawn intensive attention owing to their promising thermoelectric performance.In this work,the electrical properties of p-type Mg_(3)Sb_(2) are dramatically optimized by the regulation of Mg deficiency.Then,we,for the first time,found that Zn substitution at the Mg2 site leads to the alignment of px,y and pz orbital,resulting in a high band degeneracy and the dramatically enhanced Seebeck coefficient,demonstrated by the DFT calculations and electronic properties measurement.Moreover,Zn alloying decreases Mg1(Zn)vacancies formation energy and in turn increases Mg(Zn)vacancies and optimizes the carrier concentration.Simultaneously,the Mg/Zn substitutions,Mg vacancies,and porosity structure suppress the phonon transport in a broader frequency range,leading to a low lattice thermal conductivity of~0.47 W m^(-1) K^(-1) at 773 K.Finally,a high ZT of~0.87 at 773 K was obtained for Mg_(1.95)Na_(0.01)Zn_(1)Sb_(2),exceeding most of the previously reported p-type Mg_(3)Sb_(2) compounds.Our results further demonstrate the promising prospects of p-type Mg_(3)Sb_(2)-based material in the field of mid-temperature heat recovery. | Jinsuo Hu Jianbo Zhu Fengkai Guo Haixu Qin Yijie Liu Qian Zhang Zihang Liu Wei Cai Jiehe Sui | 2022 | Research2022，，4： | 0 |
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