|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | In situ monitoring of atmospheric nitrous acid based on multi-pumping flow system and liquid waveguide capillary cell显示文摘In the last four decades, various techniques including spectroscopic, wet chemical and mass spectrometric methods, have been developed and applied for the detection of ambient nitrous acid(HONO). We developed a HONO detection system based on long path photometry which consists of three independent modules i.e., sampling module, fluid propulsion module and detection module. In the propulsion module, solenoid pumps are applied. With solenoid pumps the pulsed flow can be computer controlled both in terms of pump stroke volume and pulse frequency, which enables the attainment of a very stable flow rate. In the detection module, a customized Liquid Waveguide Capillary Cell(LWCC) is used. The customized LWCC pre-sets the optical fiber in-coupling with the liquid wave guide, providing the option of fast startup and easy maintenance of the absorption photometry. In summer 2014, our system was deployed in a comprehensive campaign at a rural site in the North China Plain. More than one month of high quality HONO data spanning from the limit of detection to 5 ppb were collected. Intercomparison of our system with another established system from Forschungszentrum Juelich is presented and discussed. In conclusion, our instrument achieved a detection limit of 10 ppt V within2 min and a measurement uncertainty of 7%, which is well suited for investigation of the HONO budget from urban to rural conditions in China. | Yuhan Liu Keding Lu Huabin Dong Xin Li Peng Cheng Qi Zou Yusheng Wu Xingang Liu Yuanhang Zhang | 2016 | Journal of Environmental Sciences2016，28，5： | 4 |
| 3 | Com- binational numeral fingerprint spectra of Glycyrrhiza and analysis of common peak ratio invariableness in HPLC显示文摘 | ZOU Huabin YANG Guosheng DU Aiqin | 2006 | Biomed Chromatogr2006，20，64： | 1 |
| 4 | Study on the co-luminescence system Sm-Gd-BPMPHD-CTMAB and its analytical application显示文摘 | Jinghe Yang Hongmei Ge Nianqin Jie Xuozhen Ren Naixing Wang Huabin Zou | 1994 | Fresenius’ Journal of Analytical Chemistry (-)1994，，10： | 1 |
| 5 | Dual-index sequence analytical method for IR fingerprint spectra of ethanolic extract of various Gylcyrrhizae' s root species components显示文摘 | ZOU Huabin YUAN Jiurong DU Aiqin | 2005 | Analytical Letters2005，38，7： | 1 |
| 6 | Long noncoding RNAs:new insights in modulating mammalian spermatogenesis显示文摘Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes,spermatids,and finally,to mature spermatozoa.This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs(lncRNAs)and highly regulated and specific gene expression.LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored.Only a few of them have postmeiotic;however,lncRNAs are involved in many cellular biological processes.The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies.This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis. | Bahlibi Weldegebriall Sahlu Shanjiang Zhao Xiuge Wang Saqib Umer Huiying Zou Jinming Huang Huabin Zhu | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 1 |
| 7 | Progress in quality control of herbal medicine with IR fingerprint spectra显示文摘 | Zou Huabin Yang Guosheng Qin Zhengran | 2005 | Anal lett2005，38，9： | 1 |
| 8 | Dual-index sequence analytical method for IR fingerprint spectra of ethanolic extract of various Gylcyrrhizae 's root species components 显示文摘 | Zou Huabin Yuan Jiurong Du Aiqin | 2005 | Anal lett2005，38，7： | 1 |
| 9 | Dual-Index se- quence analytical method for IR fingerprint spectra of ethanolic extract of various gylcyrrhizae' s root species components 显示文摘 | Zou Huabin Yuan Jiurong Du Aiqin | 2005 | A- nal Lett2005，38，7： | 1 |
| 10 | Combinational numeral fingerprint spectra of Glycyrrhiza and analysis of common peak ratio invariableness in HPLC 显示文摘 | Zou Huabin Yang Guosheng Du Aiqin | 2006 | Biomed Chromatogr2006，20，： | 1 |
| 11 | Study on the fluorescence system Be-rutin-SDS-Triton X-100 and the determination of rutin显示文摘 | Jinghe Yang Huabin Zou Nianqin Jie Hongmei Ge Rujun Yang | 1994 | Fresenius’ Journal of Analytical Chemistry (-)1994，，5： | 1 |
| 12 | Progress in quality control of herbal medicine with IR fingerprint spectra显示文摘 | ZOU Huabin YANG Guosheng QIN Zhengran | 2005 | Analytical Letters2005，38，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员