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| 1 | Opioid growth factor and the treatment of human pancreatic cancer:A review显示文摘Opioid growth factor(OGF),chemically termed[Met5]-enkephalin,and its receptor,OGF receptor(OGFr),form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia.Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer,with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice.OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DNA synthesis and tumor growth.Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action.Preclinical studies have warranted PhaseⅠand PhaseⅡclinical trials using OGF infusions as a treatment for patients with advanced,unresectable pancreatic cancers.OGF,an endogenous neuropeptide,is a safe,non-toxic,and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression. | Ian S Zagon Patricia J McLaughlin | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Opioid growth factor improves clinical benefit and survival in patients with advanced pancreatic cancer显示文摘 | Ian S. Zagon | 2010 | Open Access Journal of Clinical Trials . 2010 (defa)2010，，： | 2 |
| 3 | Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture显示文摘 | Zagon IS Hytrek SD McLaughlin PJ | 1996 | Am J Physiol1996，271，32： | 1 |
| 4 | Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery 显示文摘 | Zagon IS Essis FM Jr Verderame MF | 2003 | J Vasc Surg2003，37，3： | 1 |
| 5 | Naltrexone,an opioid antagonist,facilitates reepithelialization of the cornea in diabetic rat显示文摘 | Zagon IS Jenkins JB Sassani JW | 2002 | Diabetes2002，51，： | 1 |
| 6 | Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus显示文摘 | Zagon IS Klocek MS Sassani JW | 2007 | Arch Ophthalmol2007，125，8： | 1 |
| 7 | The official method for the detection of genetically modified soybeans ( German Food Act LMBG 35 ) : a semi - quantitative study of sensitivitylimits with glyphosate - tolerant soybeans ( Roundup Ready) andinsect - resistant Bt maize(Maximizer) 显示文摘 | JANKIEWICZ A BROLL H ZAGON J | 1999 | J Eur Food Res Technol1999，209，2： | 1 |
| 8 | Opioids and differentiation in hu- man cancer cellsl显示文摘 | Zagon I S McLaughlin P J | 2005 | Neuropeptides2005，39，5： | 1 |
| 9 | Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor显示文摘 | McLaughlin PJ Zagon IS | 2006 | Int J Oncol2006，28，6： | 1 |
| 10 | Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers显示文摘 | Zagon IS McLaughlin PJ | 2006 | Int J Oncol2006，29，2： | 1 |
| 11 | Direct Projections from the Ventrolateral Medulla Oblongata to the Limbic Forebrain:Anterograde and Retrograde Tract-tracing Studies in the Rat 显示文摘 | ZAGON A TOTTERDELL S JONES R S | 1994 | Neurol1994，340，4： | 1 |
| 12 | Opioids and the apoptotic pathway in human cancer cells显示文摘 | Zagon IS McLaughlin PJ | 2003 | Neuropeptides2003，37，2： | 1 |
| 13 | Opioids and the apoptotic pathway in human cander cells 显示文摘 | Zagon IS McLaughlin PJ | 2003 | Neutopeptides2003，37，5： | 1 |
| 14 | Cellular dynics of corneal wound re-epithelialization in the rat Ⅱ DNA synthesis of the ocular surface epithelium following wounding显示文摘 | Zagon IS Sassani JW McLaughlin PJ | 1999 | Brain Res1999，839，2： | 1 |
| 15 | T lymphocyte pro- liferation is suppressed by the opioid growth factor ( - enkephalin)-opioid growth factorreceptor axis: implication for the treatment of autoimmune diseases 显示文摘 | Zagon IS Donahue RN Bonneau RH | 2011 | Immunobiology2011，216，5： | 1 |
| 16 | Immunological detection of osteocalcin in meat and bone meal:a novel heat stable marker for the investigation of illegal feed adulteration显示文摘 | Kreuz G Zagon J Broll H | 2012 | Food Additives & Contaminants : Part A2012，29，5： | 1 |
| 17 | Opioid growth factor arrests the progression of clinical disease and spinal cord pathol- ogy in established experimental autoimmune encephalomyelitis 显示文摘 | Campbell AM Zagon IS McLaughlin PJ | 2012 | Brain Res2012，，： | 1 |
| 18 | Insulin treatment amelioratesimpaired corneal reepithelialization in diabetic rats显示文摘 | ZAGON IS SASSANI JW MCLAUGHLIN PJ | | 0，，04： | 1 |
| 19 | Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells 显示文摘 | Zagon IS Verderame MF Hankins J | 2007 | Int J Oneol2007，30，4： | 1 |
| 20 | Epithelial adhesion complexes and organ culture of the human cornea显示文摘 | Zagon IS Sassani JW Ruth TB | 2001 | Brain Res2001，900，： | 1 |
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