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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 3 | Dual Stimuli-responsive Nano-vehicles for Controlled Drug Delivery: Mesoporous Silica Nanoparticles End- capped with Natural Chitosan显示文摘 | HAKEEM A DUAN R X ZAHID F Z etal | 2014 | Chem Commun2014，50，13： | 1 |
| 4 | Prevalence of multiple antibiotic resistant bacteria and chromosomal determinants in surface water of Bangladesh显示文摘 | Zahid H M Mahal Z Chowdhury M R | 2009 | Mrican Journal of Biotechnology2009，8，2： | 1 |
| 5 | Solid Pseudopapillary Neoplasm of the Pancreas: A Case Report with Review of the Diagnostic Dilemmas and Tumor Behavior显示文摘 | Lakhtakia R Wahaibi Zahid KF | 2013 | Oman Med J2013，28，6： | 1 |
| 6 | GhCAX3 gene,a novel Ca2+/H+ exchanger from cotton,confers regulation of cold response and ABA induced signal transduction显示文摘 | Xu L Zahid K R He L R | 2013 | PLoS ONE2013，8，66： | 1 |
| 7 | Ap-plying complementary trap characterization technique to crystallineγ-phase-Al 2 O 3 for improved understanding of nonvolatile memory operation and reliability显示文摘 | ZAHID M B AGUADO D R DEGRAEVE R | 2010 | IEEE Transactions on Electron Devices2010，57，11： | 1 |
| 8 | Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia显示文摘 | James E Cannel M Zahid R | 2007 | J Hypertens2007，25，： | 1 |
| 9 | Starch biodegradation in a lignin modified slow release fertilizer:Effect of thickness显示文摘 | ZAHID M NUR KAMILA R NURLIDIA M | 2014 | Applied Mechanics and Materials2014，，11： | 1 |
| 10 | Seroprevalence of HBV and HCV in blood donors at the blood transfusion center of mohammed V military teaching hospital in rabat morocco 显示文摘 | ZOHOUN A HADEF R ZAHID H | 2011 | MedTrop (Mars)2011，71，5： | 1 |
| 11 | Eight new diterpenoidsfrom Euphorbia decipiens显示文摘 | ZAHID M HUSANI S R ABBAS M | 2001 | Helv Chim Acta2001，84，： | 1 |
| 12 | Interaction between DNA and cationic diester - bonded Gemini surfactants 显示文摘 | ZAHID Y SAYEED U R MOHAMMAD T | 2014 | Journal of Molecular Liquids2014，197，： | 1 |
| 13 | Intubation in patients with acromegaly: experience in more than 800 patients显示文摘 | Zahid Hussain Khan Mohammad R Rasouli | 2009 | European Journal of Anaesthesiology2009，，4： | 1 |
| 14 | Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer' s disease pa- tients 显示文摘 | Zahid S Oellerich M Asif A R | 2012 | J Neurochem2012，121，6： | 1 |
| 15 | Superplasticity in an aluminum 2124/SiCp composite显示文摘 | Zahid G H Todd R I Prangnell P 13 | | 0，，09： | 1 |
| 16 | Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity 显示文摘 | Zahid N R Mitchell S A Rodney J F | 2005 | Cancer2005，5，： | 1 |
| 17 | Oil slick removal using matrices of polypropylene filaments显示文摘 | Zahid M A Halligan J E Johnson R F | 1972 | Ind Eng Chem Pro Des Dev1972，11，4： | 1 |
| 18 | Factors relating to hospitalisation and economic burden of paediatric constipation in the state of V ictoria, A ustralia, 2002–2009显示文摘 | Humaira Ansari Zahid Ansari Tracy Lim John M Hutson Bridget R Southwell | 2014 | J Paediatr Child Health2014，，12： | 1 |
| 19 | Insights into the physical properties and anisotropic nature of ErPdBi with an appearance of low minimum thermal conductivity显示文摘We theoretically study the structural, elastic and optical properties of Er Pd Bi together with its anisotropic behaviors using density functional theory. It is observed that Er Pd Bi satisfies the Born stability criteria nicely and possesses high quality of machinability. The anisotropic behavior of Er Pd Bi is reported with the help of theoretical anisotropy indices incorporating 3 D graphical presentation, which suggests that Er Pd Bi is highly anisotropic in nature. It is noticed that the minimum thermal conductivity is very low for Er Pd Bi compared to the several species. This low value of minimum thermal conductivity introduces the potentiality of Er Pd Bi in high-temperature applications such as thermal barrier coatings.In addition, deep optical insights of Er Pd Bi reveal that our material can be used in different optoelectronic and electronic device applications ranging from organic light-emitting diodes, solar panel efficiency, waveguides etc. to integration of integrated circuits. Therefore, we believe that our results will provide a new insight into high-temperature applications and will benefit for the development of promising optoelectric devices as well. | S K Mitro R Majumder K M Hossain Md Zahid Hasan Md Emran Hossain M A Hadi | 2021 | Chinese Physics B2021，30，1： | 0 |
| 20 | Therapy-related myeloid neoplasms - what have we learned so far?显示文摘Therapy-related myeloid neoplasms are neoplastic processes arising as a result of chemotherapy, radiation therapy, or a combination of these modalities given for a primary condition. The disease biology varies based on the etiology and treatment modalities patients receive for their primary condition. Topoisomerase Ⅱ inhibitor therapy results in balanced translocations. Alkylating agents, characteristically, give rise to more complex karyotypes and mutations in p53. Other etiologies include radiation therapy, high-dose chemotherapy with autologous stem cell transplantation and telomere dysfunction. Poor-risk cytogenetic abnormalities are more prevalent than they are in de novo leukemias and the prognosis of these patients is uniformly dismal. Outcome varies according to cytogenetic risk group. Treatment recommendations should be based on performance status and karyotype. An in-depth understanding of risk factors that lead to the development of therapyrelated myeloid neoplasms would help developing riskadapted treatment protocols and monitoring patients after treatment for the primary condition, translating into reduced incidence, early detection and timely treatment. | Mohammad Faizan Zahid Aric Parnes Bipin N Savani Mark R Litzow Shahrukh K Hashmi | 2016 | World Journal of Stem Cells2016，8，8： | 0 |
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