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| 1 | Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis显示文摘AIM: To study susceptibility genes which may play a potential role in the pathogenesis and etiology of inflammatory bowel disease (IBD). METHODS: To identify potential susceptibility genes we performed global gene expression profiling in patients with IBD and control specimens. For determination of an intrinsic gene expression profile in ulcerative colitis (UC) and Crohn’s disease (CD) compared to normal subjects, mucosal biopsies of non-inflamed regions of the colon and the terminal ileum were subjected to DNA microarray analysis. Real-time RT-PCR and immunohistochemistry were used for verification of selected regulated candidate genes and a genetic analysis was performed. RESULTS: We could show that aquaporin-8 (AQP8) mRNA and protein levels were significantly increased in the colon of UC patients compared to controls. Genetic analysis of the six exons and the promoter region of AQP8, however, revealed no mutations or polymorphisms in IBD patients. CONCLUSION: Our results suggest that upregulation of AQP8 in the colon of UC patients represents a secondary phenomenon which may, due to altered water exchange of the distal intestinal mucosa, disturb the physiologic colonic mucus barrier and thus lead to chronic infla- mmation and ulceration. | Alexandra Zahn Christoph Moehle Thomas Langmann Robert Ehehalt Frank Autschbach Wolfgang Stremmel Gerd Schmitz | 2007 | World Journal of Gastroenterology2007，13，11： | 13 |
| 2 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 3 | Intra-aortic balloon pump in patients with acute myocardial infarction complicated by cardiogenic shock: results of the ALKK-PCI registry显示文摘 | Uwe Zeymer Mathias Hochadel Karl-Eugen Hauptmann Klaus Wiegand Burghard Schuhmacher Johannes Brachmann Anselm Gitt Ralf Zahn | 2013 | Clinical Research in Cardiology2013，，： | 2 |
| 4 | 磷脂酰胆碱缓释剂有益于慢性活动性溃疡性结肠炎患者 | Stremmel W. Merle U. Zahn A. 赵菊辉 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，10： | 2 |
| 5 | A Clinicopathologic Analysis of 109 Cases with Emphasis on Distinguishing Pathologic Features, Site of Origin, Prognosis, and Relationship to “Pseudomyxoma Peritonei”显示文摘 | Brigite M. Ronnett Christopher M. Zahn Robert J. Kurman Mary E. Kass Paul H. Sugarbaker Barry M. Shmookler | 1995 | The American Journal of Surgical Pathology1995，，12： | 2 |
| 6 | Pseudomyxoma peritonei in women a clinicopathologic analysis of 30case with emphasis on site of origin,prognosis,and relationship to ovarian mucinous tumors of low malignant potential显示文摘 | Kurman RJ Zahn CM | 1995 | Hum Pathol1995，26，： | 1 |
| 7 | Confined reinforcement for concrete columns显示文摘 | WATSON S ZAHN F A PARK R | 1994 | Journal of Structural Engineering1994，120，6： | 1 |
| 8 | Influence of pH on NMR structure and stability of the human prion protein globular domain显示文摘 | CALZOLAI L ZAHN R | 2003 | J Biol Chem2003，278，35： | 1 |
| 9 | Development and testing ofthe Helex septal occluder, a new expanded polytetrafluoroethyleneatrial septal defect occlusion system显示文摘 | Zahn EM Wilson N Cutright W | 2001 | Circulation2001，104，6： | 1 |
| 10 | Lack of effect ofintrathecall administered NMDA receptor antagonidts in a rat model for postoperative pain 显示文摘 | PETER K ZAHN TIMOTHY J BRENNAN | 1998 | Anesthesiology1998，88，： | 1 |
| 11 | Confining Rein- forcement for Concrete Columns显示文摘 | WATSON S ZAHN F A PARK R | 1994 | Journal of Struc- tural Engineering1994，120，6： | 1 |
| 12 | Flow electrification measurements of transformer insulation using a couette flow facility显示文摘 | Washabaugh A P Zahn M | 1996 | IEEE Transac- tions on Dielectrics and Electrical Insulation1996，3，2： | 1 |
| 13 | Impulse Breakdown Delay in Liquid Dielectrics显示文摘 | Jadidian J Zahn M Lavesson N | 2012 | Applied Physics Letters2012，100，19： | 1 |
| 14 | Transcatheter aortic valve implantation: first results from a multi-centre real-world registry 显示文摘 | Zahn R Gerckens U Grube E | 2011 | Eur Heart J2011，32，2： | 1 |
| 15 | Beyond the ABC-model:regulation of floral homeotic genes显示文摘 | Zahn L M Feng B M Ma H | 2006 | Advances in Botanical Research2006，44，： | 1 |
| 16 | Sub-nanosecond pulse generator with variable pulse width using avalanche transistors显示文摘 | Rein H M Zahn M | 1975 | Electronics Letters1975，11，1： | 1 |
| 17 | Spinal Administration of MK-801 and NBQX Demonstrates NMDA-independent Dorsal Horn Sensitization in Incisional Pain显示文摘 | Zahn P K Pogatzki-Zahn E M Brennan T J | 2005 | Pain2005，114，17： | 1 |
| 18 | Safety aspects for LHe cryostats and LHe transport containers显示文摘 | Lehmann W Zahn G | 1978 | Advances in cryogenic engineering1978，23，： | 1 |
| 19 | From p reemp tive to preventive analgesia显示文摘 | Pogatzki-Zahn EM Zahn PK | 2006 | Curr Opin in Anaesthesiol2006，19，： | 1 |
| 20 | Fourier descriptors for plane closedcurves显示文摘 | C T Zahn R Z Roskies | 1972 | IEEE Trans on Computers1972，21，： | 1 |
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