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| 1 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | The NL- RP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis 显示文摘 | Zaki M H KelliL Boyd PeterVogel | 2010 | Immunity2010，221，3： | 1 |
| 3 | Short-term effects of ivabradine in patients with chronic stable ischemic heart disease 显示文摘 | Zaky H Elzein H Alsheikh-Ali AA | 2013 | Heart Views2013，14，2： | 1 |
| 4 | Subungual exostosis of the big toe: case reports 显示文摘 | Suresh SS Zaki H | 2009 | J Plast Reconstr Aesthet Surg2009，62，12： | 1 |
| 5 | Myeotoxins in an- imals: Occurrence, effects, prevention and management 显示文摘 | Zaki M M E1-Midany S A Shaheen H M | 2012 | Journal of Toxicology and Environmental Health Sciences2012，4，1： | 1 |
| 6 | Recent approach for diagnosis of early HCV infection 显示文摘 | El-Sayed Zaki M el-Adrosy H | 2004 | Egypt J Immunol2004，11，1： | 1 |
| 7 | Greenhouse evaluation of Rhizobia as biocontrol agent of root-infecting fungi in okra 显示文摘 | Siddiqui I A Ehteshamul H S Zaki M J | 2000 | Acta Agrobotanica2000，53，1： | 1 |
| 8 | Role of apoptosis controlled by cvtochrome(released from mitochondria for luteal function in human granulosa cells显示文摘 | M AKINO A ZAKI Y MATSUHARA H | 2005 | Am T Reprocl Immunol2005，53，3： | 1 |
| 9 | Relevance of parvovirus B19, herpes simplex virus,and cytomegalovirus virologic markers in maternal serum for diagnosis of unexplained recurrent abortions 显示文摘 | El-Sayed Zaki M Goda H | 2007 | Arch Pathol Lab Med2007，131，6： | 1 |
| 10 | Synthesis of coupled-resonators group-delay equalizers 显示文摘 | Hsu H T Yao H W Zaki K A | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，8： | 1 |
| 11 | Modification of cell development in vitro:the effect of colchicines on anther and isolated microspore culture in Brassica napus显示文摘 | Zaki M Dickinson H | 1995 | Plant Cell Tissue and Organ Culture1995，40，： | 1 |
| 12 | Relevance of parvovirus B19,herpes simplex virus 2 and cytomegalovirus virologic markers in maternal serum for diagnosis of unexplained recurrent abortions显示文摘 | el-Sayed Zaki M Goda H | 2007 | Arch Pathol Lab Med2007，131，6： | 1 |
| 13 | Computer-aided diagnosis and tuning of cascaded coupled resonators filters显示文摘 | H T Hsu H W Yao K A Zaki | 2002 | IEEE Transactions on Microwave Theoty and Technique2002，50，4： | 1 |
| 14 | Hindbrain decompression for Chiari-synngomyelia complex:an outcome analysis comparing surgical techniques显示文摘 | Hayhurst C Richards O Zaki H | 2008 | Br J Neurosurg2008，22，1： | 1 |
| 15 | Calcium movements,distribution,and functions in smooth muscle显示文摘 | ZAKI H HOR M | 1997 | Pharm Rev1997，49，2： | 1 |
| 16 | Radioactive Gold grain implants in recurrent and locally advanced head and neck cancers显示文摘 | Ashamalla H Rafla S Zaki B | 2002 | Brachytherapy2002，1，： | 1 |
| 17 | Poly(glycerol sebacate)elastomer:A novel material for mechanically loaded bone regeneration显示文摘 | Zaky S H Lee K W Gao J | 2014 | Tissue Eng Part A2014，20，12： | 1 |
| 18 | Computer-aided Diagnosis and Tuning of Cascaded Coupled Resonators Filters显示文摘 | Hsu H T Yao H W Zaki K A | 2002 | IEEE Trans on Microwave Theory Tech2002，50，4： | 1 |
| 19 | Hindbrain decompression for Chiari-syringomyelia complex: an outcome analysis comparing surgical techniques 显示文摘 | Hayhurst C Richards O Zaki H | 2008 | Br J Neurosurg2008，22，1： | 1 |
| 20 | GRAIL: scalable reachabili- ty index for large graphs 显示文摘 | YILDIRIM H CHAOJI V ZAKI M J | 2010 | PVLDB Journal2010，3，1： | 1 |
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