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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | 全球本科医学教育认证概览显示文摘全球范围内本科医学教育的架构及质量差异很大,认证过程有助于医学院校改进教学、提高质量。本文对世界各国医学教育认证体系进行了全面概述,重点阐述了其区域差异性。了解当前全球医学教育认证现状,对于深入开展认证过程与教育结果之间的相关性研究极为重要。 | Marta van Zanten 汪青 | 2009 | 复旦教育论坛2009，7，2： | 9 |
| 3 | Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants显示文摘 | Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters | 2012 | Molecular Plant2012，5，4： | 3 |
| 4 | Shedding Light on Large-Scale Chromatin Reorganization in Arabidopsis thaliana显示文摘植物需要从环境对轻信号的各种各样的类型快速并且适当地作出回应优化生长和开发。对 shading,减少的光子流动(低光) ,和变化在的立即的反应光谱质量在基因规定包含变化。在更坚持的色泽的情况中,植物在染色质的组织显示出一个戏剧的变化。两植物反应经由表明蛋白质的光敏电阻器被控制。最近,几研究响应各种各样的不能生活、关於生命的信号揭示了染色质重组的类似的特征,当其它揭开了向基因规定的轻发信号的复杂分子的网络时。这份意见报纸简短描述染色质(de ) 对的从一个轻发信号的观点的压缩反应提供在染色质和光敏电阻器和 E3 ubiquitin ligase 建筑群的分子的网络之间的一个连接。 | Martijn van Zanten Federico Tessadori Anton J.M. Peeters Paul Fransz | 2012 | Molecular Plant2012，5，3： | 3 |
| 5 | Die Montreal-Definition und -Klassifikation der gastro?sophagealen Refluxkrankheit: Ein globales evidenzbasiertes Konsensus-Papier显示文摘 | N Vakil S van Zanten P Kahrilas J Dent R Jones | 2007 | Z Gastroenterol2007，，11： | 3 |
| 6 | Overview of accreditation of undergraduate medical education programmes worldwide显示文摘 | MartaVan Zanten John JNorcini John RBoulet FrankSimon | 2008 | Medical Education2008，，9： | 2 |
| 7 | The montreal definition and classification of gastroesophageal reflux disease:a global evidence-based consensus显示文摘 | Vakil N Van Zanten SV Kahrilas P | 2006 | Am I Gastroenterol2006，101，： | 1 |
| 8 | Efficacy of cisapride and domperidone in functional (nonulcer) dyspepsia : a recta-analysis 显示文摘 | Veldhuyzen van Zanten SJ Jones MJ Verlinden M Talley NJ | 2001 | Am J Gastroenterol2001，96，： | 1 |
| 9 | The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus 显示文摘 | Vakil N van Zanten S V Kahrilas P | 2006 | Am J Ga- stroenterol2006，101，8： | 1 |
| 10 | Clinical validation of the non-invasive cardiac outputmonitor USC0M-1A in critically ill patients 显示文摘 | van Lelyvele-Haas LE van Zanten AR Bonn GF | 2008 | Eur JAnaesthesiol2008，25，11： | 1 |
| 11 | The Montrealdefinition and classification of gastroesophageal reflux disease: a global evidence-based consensus显示文摘 | Vakil N van Zanten SV Kahrilas P | 2006 | Am J Gastroenterol2006，101，19： | 1 |
| 12 | Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia cmpiric treatment Helicobacter pylori positive (CADET-HP) randomized controlled trial显示文摘 | CHIBA N VELDHUYZEN VAN ZANTEN SJ SINCLAIR P | 2002 | BMJ2002，324，： | 1 |
| 13 | Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: an updated meta-analysis 显示文摘 | Teshima CW Kuipers EJ van Zanten SV | 2011 | J Gastroenterol Hepatol2011，26，5： | 1 |
| 14 | Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled 'ENTER' trial 显示文摘 | van Zanten S V Armstrong D Chiba N | 2006 | Am J Gastroenterol2006，101，9： | 1 |
| 15 | The Montreal definition and classification of gastroesophageal reflux disease:a global evidence-based consensus显示文摘 | Vakil N van Zanten S V Kahrilas P | 2006 | Am J Gastroenterol2006，101，8： | 1 |
| 16 | Prospective study on the dose relationship of mitomycin C -induce interstitial pneumonitis显示文摘 | Verweij J van Zanten T Souren T | 1987 | Cancer1987，60，4： | 1 |
| 17 | Officially realeased mutant varieties in China显示文摘 | Liu L Van Zanten L Shu Q Y | 2004 | Mutation Breeding Review2004，14，： | 1 |
| 18 | The Montreal definition and classification of gastroesophageal reflux disease:A global evidence-based consensus显示文摘 | Vakil N van Zanten SV Kahrilas P | | 0，，08： | 1 |
| 19 | Efficacy of cisapride and domperidone in functional (nonul-cer) dyspepsia:a meta-analysis显示文摘 | Veldhuyzen van Zanten SJ Jones M J Verlinden M Talley NJ | | 0，，96： | 1 |
| 20 | Recurrent massive haematemesis from Dieulafoy vascular malformations--a review of 101 cases显示文摘 | Veldhuyzen van Zanten SJ Bartelsman JF Schipper ME | | 0，，： | 1 |
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