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| 1 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 2 | Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control显示文摘 | Zbao B Wei X M Li W Q | 2007 | Genes Dev2007，21，21： | 1 |
| 3 | Neuroprotective properties of eatalpol on transient global cerebral ischemia in gerbils:dose-response,therapeutic time-window and long-term efficacy显示文摘 | Dan Qing Li Yong Ming Bao Jun Jun Zbao | 2004 | Brain Research2004，，1029： | 1 |
| 4 | iPS cells produce viable mice through tetraploid complementation 显示文摘 | Zbao XY Li W Lv Z | 2009 | Nature2009，461，7260： | 1 |
| 5 | 7-Difluoromethyl-5,4'-dimethoxygenistein,a novel genistein derivative,has therapeutic effects on atherosclerosis in a rabbit model显示文摘 | Zbao H Li C Cao JG Xiang HL Yang HZ You JL | 2009 | J Cardiovasc Pharmacol2009，54，5： | 1 |
| 6 | Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats 显示文摘 | Zbao Z Li L | 2015 | DrugDeliv2015，22，1： | 1 |
| 7 | Association analysis between interleu- kin-1 family polymorphisms and generalized aggressive periodontitis in s Chinese population显示文摘 | Li QY Zbao HS Meng HX | 2004 | Periodontal2004，75，12： | 1 |
| 8 | Treatment of type C pilon fractures by external fixator combined with limited open reduction and ab- sorbable internal fixation 显示文摘 | Zbao L Li Y Chen A | 2013 | Foot Ankle Int2013，34，4： | 1 |
| 9 | On-site treatment of dyeing wastewater by a bio-photoreactor system显示文摘 | Li X Z Zbao Y G | 1997 | War Sci Tech1997，36，： | 1 |
| 10 | Metal speciation measurement by diffusive gradients in thin films technique with different binding phases 显示文摘 | Li W J Zbao H J Teasdale P R | 2005 | Analytica Chimica Acta2005，533，2： | 1 |
| 11 | Efficacy and safety of pareeoxib sodium for acute postoperative pain: a meta-analysis 显示文摘 | Wei W Zbao T Li Y | 2013 | Exp Ther Med2013，6，2： | 1 |
| 12 | 17beta-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation显示文摘 | Yu J Zbao Y Li B | 2012 | J Biochem Mol Toxicol2012，26，7： | 1 |
| 13 | Structure and mechanical properties of ceramic coatings fabricated by micro-arc oxidation 显示文摘 | Li H X Song R G Zbao J | 2005 | Advanced Materials Research2005，4750，： | 1 |
| 14 | Image retrieval based on muhidensional feature properties显示文摘 | Ang Y H Zbao LI Ong SH | 1995 | In Proceedings of STIP: Storage and Retrieval for Image and Video Database1995，2420，： | 1 |
| 15 | Influence of mineral matter in coal on decomposition of NO over chars and emissions of NO during char combustion 显示文摘 | Zbao Zongbin Qiu Jieshan Wen Li | 2003 | Fuel2003，82，3： | 1 |
| 16 | The formation mechanism of non-dendritic primary α-Al phase in semi-solid AlSi7Mg Alloy显示文摘 | Mao Weimin Li Yanjun Zbao Aimin | 2001 | Science and Technology of Advanced Materials2001，，2： | 1 |
| 17 | Human Capital, Economic Growth, and Regional Inequality in China显示文摘 | Fleisher B Li Haizheng Zbao Minqiang | 2010 | Journal of Development Economics2010，92，2： | 1 |
| 18 | Study on the Total Synthesis of 3-Oxo-9β-Acetoxyilicic Acid─The Synthesis of 9β-Acetoxy-3(4),11(13)-Dien-5αH,7αH-12-Eudesmanoic Acid Methyl Ester显示文摘The synthesis of 99-acetoxy-3(4), 11(13)-dien-5αH 7αH-12-eudesmanoic acid methyl ester (2) was achieved from oxycarvone. The key step is the p-toluenesulfonhydrazide assisted reductiv rearrangement | Jiong YANG Zbao Ming XIONG Yong Gang CREN and Yu Lin LI(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,ho University, Lanzhou 730000) | 1997 | Chinese Chemical Letters1997，8，12： | 0 |
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