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| 1 | Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model: In vitro and in vivo studies显示文摘Bone defects are commonly caused by severe trauma,malignant tumors,or congenital diseases and remain among the toughest clinical problems faced by orthopedic surgeons,especially when of critical size.Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility,suitable degradation rate,and favorable osteogenesis-promoting properties.The biphasic activity of Sr promotes osteogenesis and inhibits osteoclastogenesis,which imparts Zn-Sr alloys with the ideal theoretical osteogenic properties.Herein,a biodegradable Zn-Sr binary alloy system was fabricated.The cytocompatibility and osteogenesis of the Zn-Sr alloys were significantly better than those of pure Zn in MC3T3-E1 cells.RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/β-catenin,PI3K/Akt,and MAPK/Erk signaling pathways.Furthermore,rat femoral condyle defects were repaired using Zn-0.8Sr alloy scaffolds,with pure Ti as a control.The scaffold-bone integration and bone ingrowth confirmed the favorable in vivo repair properties of the Zn-Sr alloy,which was verified to offer satisfactory biosafety based on the hematoxylin-eosin(H&E)staining and ion concentration testing of important organs.The Zn-0.8Sr alloy was identified as an ideal bone repair material candidate,especially for application in critical-sized defects on load-bearing sites due to its favorable biocompatibility and osteogenic properties in vitro and in vivo. | Bo Jia Hongtao Yang Zechuan Zhang Xinhua Qu Xiufeng Jia Qiang Wu Yu Han Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，6： | 9 |
| 2 | Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites:In vitro and in vivo studies显示文摘A novel biodegradable metal system,ZnLiCa ternary alloys,were systematically investigated both in vitro and in vivo.The ultimate tensile strength(UTS)of Zn0.8Li0.1Ca alloy reached 567.60±9.56 MPa,which is comparable to pure Ti,one of the most common material used in orthopedics.The elongation of Zn0.8Li0.1Ca is 27.82±18.35%,which is the highest among the ZnLiCa alloys.The in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid(SBF)showed significant acceleration than that of pure Zn.CCK-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good biocompatibility.Real-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes(ALP,COL-1,OCN and Runx-2),especially the OCN.An in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks,aiming to treat the bone defects.The Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti scaffold.Zn0.8Li0.1Ca alloy showed great potential to be applied in orthopedics,especially in the load-bearing sites. | Zechuan Zhang Bo Jia Hongtao Yang Yu Han Qiang Wu Kerong Dai Yufeng Zheng | 2021 | Bioactive Materials2021，6，11： | 3 |
| 3 | High Efficiency and Anomalous Photoacoustic Behavior in Vertical CNTs Array显示文摘Miniaturized sound generators are attractive to realize intriguing functions.Thermoacoustic device’s application is seriously limited due to the frequency-doubling phenomenon.To address this issue,photoacoustic sound generator is considered as a promising alternative.Here,based on vertical single-wall carbon nanotubes(CNTs)array,we introduce a photoacoustic sound generator with internal nano-Helmholtz cavity.Different from traditional device that generates sound by periodically heating up the open space air around material,this sound generator produces an audio signal by forming a forced vibration of the air inside the CNTs.Interestingly,anomalous photoacoustic behavior is observed that the sound pressure level(SPL)curve has a resonance peak,the corresponding frequency of which is inversely proportional to the CNTs array’s height.Furthermore,the energy conversion efficiency of this photoacoustic device is 1.64 times as large as that of a graphene sponge-based photoacoustic device.Most importantly,this device can be employed for music playing,bringing a new clew for the development of musical instruments in the future. | Jiapu Li Ziyu Wang Laiming Jiang Zechuan Yu Xu Ge Jun Ouyang Xiaofei Yang Xiaobao Tian He Tian Benpeng Zhu | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 4 | Atomic insight into the functionalization of cellulose nanofiber on durability of epoxy nanocomposites显示文摘Chemical functionalization is an effective approach to address interfacial deterioration caused by environmental exposure in cellulose nanofiber(CNF)-epoxy nanocomposites.However,how functionalization affects interfacial deterioration and durability of nanocomposites in erosive environment is still lacked.In this work,the global mechanical properties and local interfacial intermolecular behavior of pristine and functionalized CNF-reinforced nanocomposites are investigated through molecular dynamics simulations.The results show that functionalization can enhance the interfacial energy barrier and debonding stress by 43%and 57%,respectively.Functionalized CNF inhibits the slippage of epoxy chains,ensuring better interfacial adhesion and efficient stress transfer between fiber and matrix.Functional groups promote the formation of interfacial bridging and topological structures and weaken the hydrogen bonding ability of water molecules,leading to stronger intermolecular adsorption effect and better interfacial integrity.The epoxy molecular configuration evolution and intermolecular interactions,caused by the functionalization of CNF in the interfacial region,enhance the interfacial erosion resistance,contributing to the durability of the nanocomposites.This study reveals the in-depth interfacial deterioration mechanism of functionalized nanocomposites under erosive environment,inspiring a novel strategy for the design of durable CNF-reinforced nanocomposites. | Tiejun Liu Kexuan Li Ao Zhou Zechuan Yu Renyuan Qin Dujian Zou | 2023 | Nano Research2023，16，2： | 0 |
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