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| 1 | Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection显示文摘It has been known that,the novel coronavirus,2019-nCoV,which is considered similar to SARS-CoV,invades human cells via the receptor angiotensin converting enzyme II(ACE2).Moreover,lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection.However,some patients also exhibit non-respiratory symptoms,such as kidney failure,implying that 2019-nCoV could also invade other organs.To construct a risk map of different human organs,we analyzed the single-cell RNA sequencing(scRNA-seq)datasets derived from major human physiological systems,including the respiratory,cardiovascular,digestive,and urinary systems.Through scRNA-seq data analyses,we identified the organs at risk,such as lung,heart,esophagus,kidney,bladder,and ileum,and located specific cell types(i.e.,type II alveolar cells(AT2),myocardial cells,proximal tubule cells of the kidney,ileum and esophagus epithelial cells,and bladder urothelial cells),which are vulnerable to 2019-nCoV infection.Based on the findings,we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection.This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection. | Xin Zou Ke Chen Jiawei Zou Peiyi Han Jie Hao Zeguang Han | 2020 | Frontiers of Medicine2020，14，2： | 193 |
| 2 | Gene editing and its applications in biomedicine显示文摘The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats(CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. The application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability. Here, we provide a general summary of emerging biomedical applications of genome editing, including open challenges. We also summarize the tools of genome editing and the insights derived from their applications, hoping to accelerate new discoveries and therapies in biomedicine. | Guanglei Li Xiangyang Li Songkuan Zhuang Liren Wang Yifan Zhu Yangcan Chen Wen Sun Zeguang Wu Zhuo Zhou Jia Chen Xingxu Huang Jin Wang Dali Li Wei Li Haoyi Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 8 |
| 3 | Recent progress in 8igenomic research of liver cancer显示文摘Along the course of occurrence and development of liver cancer,the corresponding somatic cells accumulate some important genetic variations.These variations may be divided into two categories.For the genetic changes closely related to etiology of liver cancer,the well-known cases include insertion and integration of the hepatitis B virus(HBV) DNA after infection,and mutations at site 249 of the tumor suppressor gene p53 induced by exposure to aflatoxin B1.The secondary genetic changes include amplification and deletion of certain chromosome regions,mutations in p53 at the sites other than 249,as well as the mutational activation of the Wnt/β-catenin signal pathway.The tumor cells with these genetic variations may gradually become the dominant clones under evolutionary selection.Besides,identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field. | HAN ZeGuang Shanghai-MOST Key Laboratory for Disease and Health Genomics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China | 2009 | Science China(Life Sciences)2009，52，1： | 7 |
| 4 | A transient multiphysics coupling method based on OpenFOAM for heat pipe cooled reactors显示文摘Differing from traditional pressurized water reactors(PWRs),heat pipe cooled reactors have the unique characteristics of fuel thermal expansion,expansion reactivity feedback,and thermal contact conductance.These reactors require a new multiphysics coupling method.In this paper,a transient coupling method based on OpenFOAM is proposed.The method considers power variation,thermal expansion,heat pipe operation,thermal contact conductance,and gap conductance.In particular,the reactivity feedback caused by working medium redistribution in a heat pipe is also preliminarily considered.A typical heat pipe cooled reactor KRUSTY(Kilowatt Reactor Using Stirling TechnologY)is chosen as the research object.Compared with experimental results of load following,the calculated results are in good agreement and show the validity of the proposed method.To discuss the self-adjusting capability of this type of reactor system,a hypothetical accident is simulated.It is assumed that at the beginning of this accident,loss of the heat sink occurs.After 1500 s of the transient process,the reactor system recovers immediately.During this hypothetical accident,the control rod is always out of the reactor core,and the reactor only relies on the reactivity feedback to regulate the fission power.According to the simulation,the peak temperature is only about 1112 K,which is far below the safety limit.As for system recovery,the reactor needs approximately 2500 s to return to a steady state and can realize effective power regulation by reactivity feedback.This study confirms the availability of this coupling method and that it can be an effective tool for the simulation of heat pipe cooled reactors. | GUO YuChuan LI ZeGuang WANG Kan SU ZiLin | 2022 | Science China(Technological Sciences)2022，65，1： | 4 |
| 5 | Treating acute large vessel occlusion stroke:to bridge or not to bridge?显示文摘Hot debates exist regarding whether patients who had an acute large vessel occlusion stroke(LVOS)can skip tissue plasminogen activator(tPA)and go directly to thrombectomy in comprehensive stroke centres.Three head-to-head randomised clinical trials(RCTs)of direct endovascular treatment(dEVT)versus bridge therapy(BT)with intravenous alteplase have been recently completed in the Asian population.The DIRECT-MT(Direct Intraarterial Thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals:a Multicenter Randomized Clinical Trial)Study randomly enrolled 656 patients who had an acute ischaemic stroke with anterior circulation LVOS across 41 large teaching hospitals in China to receive BT or dEVT within 4.5 hours after symptom onset. | Yunyun Xiong Yuesong Pan Raul G Nogueira Zeguang Ren Tudor G Jovin Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 6 | Demographic change, savings, investment, and economic growth显示文摘 | Xing Li Zeguang Li | 2012 | The Chinese Economy2012，，45： | 1 |
| 7 | Significant flow velocity reduction at the intracranial aneurysm neck after endovascular treatment leads to favourable angiographic outcome:a prospective study显示文摘Background With widely usage of flow diverter in intracranial aneurysm treatment,some previously used predictors may not be effective in evaluating the recurrence risk.We aimed to comprehensively re-evaluate the predictors of intracranial aneurysm outcome with various endovascular treatment methods and devices.Methods This is a prospective registered study.We analysed 6-month and 18-month follow-up angiographic data from the prospective study.Data on patient demographics,aneurysm morphology and type of treatment were recorded.Patient-specific haemodynamic simulations were performed.An unfavourable angiographic outcome was defined as recurrence of aneurysm in cases with coiling or stent-assisted coiling,patency of aneurysm in cases with flow diverters or retreatment during follow-up.Results In total,165 patients(177 intracranial aneurysms)with at least one angiographic follow-up data were analysed.For the short-term(6-month)results,after univariate analysis,the demographic,morphological and treatment-related factors did not achieve significantly statistical differences.The reduction ratio(RR)of velocity at aneurysm neck after embolisation was significantly lower in the unfavourable angiographic group than the favourable angiographic outcome group(p=0.002).After the Cox regression analysis,the RR of velocity at aneurysm neck was the only independent factor associated with favourable angiographic outcome(OR 0.028;p=0.001)and had an acceptable area under the curve(0.714)with a clear cut-off value(46.14%).Similarly,for the analysis of midterm(18-month)results,the RR of velocity at the aneurysm neck was the only independent significant factor for the unfavourable angiographic outcome(OR 0.050;p=0.017).The area under the curve was 0.754 and the cut-off value was 48.20%.Conclusions The haemodynamics showed an independent effect on angiographic follow-up results and may provide helpful suggestions for clinical practice in the future. | Zhongbin Tian Jian Liu Jay Kumar Wenqiang Li Yisen Zhang Ying Zhang Kun Wang Shengzhang Wang Zeguang Ren Xinjian Yang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 8 | Acute liver failure:mechanisms of immune-mediated liver injury 显示文摘 | Zeguang W Meifang H Tao C | 2010 | Liver interna-tional2010，30，6： | 1 |
| 9 | Prediction of the vortex yarn tenacity from some process and nozzle parameters based on numerical simulation and artificial neural network显示文摘 | Zeguang Pei Chongwen Yu | 2011 | Tex- tile Research Journal2011，0，00： | 1 |
| 10 | Numerical study on the effect of nozzle pressure and yarn delivery speed on the fiber motion in the nozzle of Murata vortex spinning显示文摘 | PEI Zeguang YU Chongwen | 2011 | Journal of Fluids and Structures2011，27，： | 1 |
| 11 | siRNA mediated the type 1 insulin-like growth factor receptor and epidermal growth factor receptor silencing induces chemosensitization of liver cancer cells显示文摘 | Jian Niu Xiang-nong Li Haixin Qian Zeguang Han | 2008 | Journal of Cancer Research and Clinical Oncology2008，，4： | 1 |
| 12 | Developmentand benchmark validation of a new MC neutron transport codeRMC for reactor analysis显示文摘 | LI Zeguang WANG Kan SHE Ding | 2010 | Transaction of AmericanNuclear Society2010，103，： | 1 |
| 13 | Major-Country Diplomacy with Chinese Characteristics in the New Era显示文摘 | Zheng Zeguang | 2018 | 国际问题研究2018，，3： | 1 |
| 14 | A study of spray granulation in vibrated fluidized bed with internal heating tubes显示文摘The granulation process in a vibratedfluidized bed with immersed horizontal heating tubes was studied in this paper,with small monoammonium phosphate particles as the initial particles and monoammonium phosphate solution sprayed on them.The concrete influences on the granulating performance of the immersed horizontal heating power,fluidizing gas velocity,vibration frequency and amplitude had been analyzed theoretically.The results show that appropriate vibration intensity is a preferred condition for the growth of partials,but thefine dust will become much more along with prolonged vibration.Increasing the heating power is beneficial to raise the growth rate.Particles will grow faster if thefluidizing gas velocity is higher,but this will cause morefine dust.The optimized condition of A=0.002 m,f=6.67 Hz,u=1.4 m/s was given after the analysis of the experimental results.In the end,a semiempirical formula was derived from the experiment data,and the calculation results show good agreement with the experimental data. | Xiaoheng PAN Shichao YE Zeguang ZHANG Li ZHANG Xuejun ZHU | 2009 | Frontiers of Chemical Science and Engineering2009，3，1： | 0 |
| 15 | Endovascular therapy in acute anterior circulation large vessel occlusive patients with a large infarct core(ANGEL-ASPECT):protocol of a multicentre randomised trial显示文摘Background The benefit of stroke thrombectomy for large infarct core still lacks robust randomised controlled studies.Aim To demonstrate the design of a clinical trial on endovascular therapy for acute anterior circulation large vessel occlusion(LVO)patients with large infarct core volume.Design ANGEL-ASPECT is a multicentre,prospective,randomised,open-label,blinded End-point trial to evaluate whether best medical management(BMM)combined with endovascular therapy improves neurological functional outcomes as compared with BMM alone in acute LVO patients with Alberta Stroke Program Early CT Score(ASPECTS)of 3-5 on non-contrast CT or infarct core volume range of 70-100 mL(defined as rCBF<30%on CT perfusion or ADC<620 on MRI)up to 24 hours from symptom onset or last seen well.Study outcomes The primary efficacy outcome is 90(±7)days modified Rankin Scale.Symptomatic intracranial haemorrhage within 48 hours from randomisation is the primary safety outcome.Discussion The ANGEL-ASPECT trial will screen patients with large infarct core(ASPECTS 3-5 or 70-100 mL)through image evaluation criteria within 24 hours and explore the efficacy and safety of endovascular therapy compared with BMM. | Xiaochuan Huo Gaoting Ma Xuelei Zhang Yuesong Pan Xu Tong Dapeng Sun Liping Liu Yilong Wang David S Liebeskind Yongjun Wang Vitor Mendes Pereira Zeguang Ren Zhongrong Miao | 2023 | Stroke & Vascular Neurology2023，8，2： | 0 |
| 16 | Seventy Years of Diplomatic Achievements Since the Founding of the People’s Republic of China显示文摘The birth of the People’s Republic of China 70 years ago set China’s foreign relations on a momentous and dauntless journey.Under the leadership of the Communist Party of China(CPC),China’s foreign policy in the past seven decades has been focused on promoting national rejuvenation,domestic development and reform and opening-up,on safeguarding China’s sovereignty,security and development interests,and on maintaining world peace and bolstering common development. | Zheng Zeguang | 2019 | China International Studies2019，64，5： | 0 |
| 17 | 靶向IGF1R的siRNA抑制人肝癌细胞SMMC7721裸鼠移植瘤的实验研究(英文)显示文摘调查像胰岛素的生长因素 1 受体(IGF1R ) 的效果的目的在裸体老鼠的人的肝癌症 SMMC7721 房间异种皮移植的生长上的小介入 RNA (siRNA ) 。指向 IGF1R 的方法 siRNA 被设计,并且原生质标志 SMMC7721-IGF1R-siRNA 被构造并且 transfected 进 SMMC7721 房间(SMMC7721-IGF1R-siRNA 房间) ;有 SMMC7721-IGF1R-mutation (SMMC7721-IGF1R-mutation 房间) 的房间 transfected 作为空控制被用作否定控制,和 untransfected 房间。稳定的房间克隆被 G418 屏蔽,并且移植了进裸体老鼠建立癌症异种皮移植。肿瘤生长被监视。肿瘤形态学被观察与他染色。在肿瘤纸巾的 IGF1R 蛋白质的表示被西方的污点检测。在肿瘤纸巾的 Microvessel 密度(MVD ) 被 SP 免疫组织化学检测。房间 apoptosis 被终端 deoxynucleotidyl 检测调停 transferase 的 dUTP 刻痕标记结束(TUNEL ) 试金。结果肿瘤体积比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更小的(P <
0.05 ) 。坏死和房间 apoptosis 在 SMMC7721-IGF1R-siRNA 组被发现。IGF1R 蛋白质的表示比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF-1R-siRNA 组是显著地更低的(P <
0.05 ) 。MVD 比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更低的(11.3 ± 4.4 对 36.7 ± 7.6 和 28.4 ± 6.5, P <
0.05 ) 。肿瘤房间的 apoptosis 率比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更高的[(50.2 ± 6.4 )% 对(5.4 ± 1.0 )% 或(6.0 ± 2.1 )% , P <
0.05 ] 。结论 IGF1R siRNA 能在裸体老鼠禁止 SMMC7721 细胞异种皮移植的生长。 | Jian Niu Haixin Qian Xiangnong Li Zeguang Han | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 18 | Review of The Theoretical and Empirical Study on the Interest Conflict Between City Groups显示文摘The Theoretical and Empirical Study on the Interest Conflict Between City Groups Author:Miao Jianjun Year:2014Publisher:Economy&Management Publishing House ISBN:9787509629482(240 pages,in Chinese)Since the application of the strategy'Rising of Central China,'provinces in China’s central region consecutively released their | Guo Zeguang Qian Fang | 2016 | China City Planning Review2016，25，2： | 0 |
| 19 | Prognostic model for prostate cancer based on glycolysis-related genes and non-negative matrix factorization analysis显示文摘Background:Establishing an appropriate prognostic model for PCa is essential for its effective treatment.Glycolysis is a vital energy-harvesting mechanism for tumors.Developing a prognostic model for PCa based on glycolysis-related genes is novel and has great potential.Methods:First,gene expression and clinical data of PCa patients were downloaded from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO),and glycolysis-related genes were obtained from the Molecular Signatures Database(MSigDB).Gene enrichment analysis was performed to verify that glycolysis functions were enriched in the genes we obtained,which were used in nonnegative matrix factorization(NMF)to identify clusters.The correlation between clusters and clinical features was discussed,and the differentially expressed genes(DEGs)between the two clusters were investigated.Based on the DEGs,we investigated the biological differences between clusters,including immune cell infiltration,mutation,tumor immune dysfunction and exclusion,immune function,and checkpoint genes.To establish the prognostic model,the genes were filtered based on univariable Cox regression,LASSO,and multivariable Cox regression.Kaplan–Meier analysis and receiver operating characteristic analysis validated the prognostic value of the model.A nomogram of the risk score calculated by the prognostic model and clinical characteristics was constructed to quantitatively estimate the survival probability for PCa patients in the clinical setting.Result:The genes obtained from MSigDB were enriched in glycolysis functions.Two clusters were identified by NMF analysis based on 272 glycolysis-related genes,and a prognostic model based on DEGs between the two clusters was finally established.The prognostic model consisted of LAMPS,SPRN,ATOH1,TANC1,ETV1,TDRD1,KLK14,MESP2,POSTN,CRIP2,NAT1,AKR7A3,PODXL,CARTPT,and PCDHGB2.All sample,training,and test cohorts from The Cancer Genome Atlas(TCGA)and the external validation cohort from GEO showed significant differences between the high-risk and low-risk groups.The area under the ROC curve showed great performance of this prognostic model.Conclusion:A prognostic model based on glycolysis-related genes was established,with great performance and potential significance to the clinical application. | ZECHAO LU FUCAI TANG HAOBIN ZHOU ZEGUANG LU WANYAN CAI JIAHAO ZHANG ZHICHENG TANG YONGCHANG LAI ZHAOHUI HE | 2023 | BIOCELL2023，47，2： | 0 |
| 20 | Major-Country Diplomacy with Chinese Characteristics in the New Era显示文摘President Xi Jinping declared in his report to the 19th National Congress of the CPC that socialism with Chinese characteristics has entered a new era.This is a new historical context set for China’s development and for its distinctive major-country diplomacy.This major-country diplomacy with Chinese characteristics in the new era is underpinned by China’s diplomatic practice since the founding of the PRC and in particular by innovations in diplomatic theory and practice after the 18th CPC National Congress. | Zheng Zeguang | 2018 | China International Studies2018，63，3： | 0 |
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