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| 1 | Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone显示文摘Crohn's disease(CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications.The purpose of treatment is long-term remission,reduction of complications,and improvement of patients' quality of life.In many cases,this can be quite challenging and it is necessary to have a well thought out management strategy.We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia.In addition,there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities,indicative of pyoderma gangrenosum.The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab.A positive response to adalimumab therapy was observed:after 2 mo of therapy,the ulcerative skin lesion healed completely and the enterogastric fistula was closed after 5 mo adalimumab treatment.Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD. | Eva Zold Arpad Nagy Katalin Devenyi Margit Zeher Zsolt Barta | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 2 | Microscopic colitis: A retrospective study of clinical presentation in 53 patients显示文摘AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and diarrhea.METHODS: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively analyzed.RESULTS: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation subgroup.CONCLUSION: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups. | Zsolt Barta Gabriella Mekkel István Csíp(o|') László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher | 2005 | World Journal of Gastroenterology2005，11，9： | 3 |
| 3 | Pulse cyclophosphamide therapy for inflammatory bowel disease显示文摘AIM:To assess the efficacy of intravenous cyclophos-phamide pulse therapy for refractory inflammatory boweldisease(IBD).METHODS:We included in our cohort eight patientswith(moderate/severe)steroid refractory IBD(4 withulcerative colitis and 4 with Crohn's disease).They allreceived 6 cycles of intravenous cyclophosphamide(800mg)per month.RESULTS:Patients entered into remission after the sec-ond/third cyclophosphamide pulse.Disease activity de-creased.There were no side effects and toxicity.All thepatients went into long lasting remission.All Crohn's diseasepatients and 3 of 4 ulcerative colitis patients achievedcomplete remission.One patient with ulcerative colitisshowed an impressive clinical response but did not enterinto remission.For the maintenance,patients with Crohn'sdisease were treated with methotrexate(15 mg/wk)andpatients with ulcerative colitis were treated with azathio-prine(2.5 mg/kg body weight/d).CONCLUSION:Remission was maintained in all pa-tients for 6 mo on the average.The drug was well toler-ated.These findings suggest that aggressive immuno-suppressive therapy may be useful in some refractorypatients and further controlled study should be consid-ered in order to fully evaluate this type of treatment as apotential therapy for IBD. | Zsolt Barta László Tóth Margit Zeher | 2006 | World Journal of Gastroenterology2006，12，8： | 2 |
| 4 | Bubble dissolution in viscous in simple shear flow 显示文摘 | Moshe Faveluris Zeher Tadmor Yeshayahu Talmon | 1995 | AICHE Journal1995，41，12： | 1 |
| 5 | Do autoantibodies predict autoimmune liver disease in primary Sjogren's syndrome? Data of 180 patients upon a 5 year follow-up显示文摘 | Csepregi A Szodoray P Zeher M | 2002 | Scand J Immunol2002，56，： | 1 |
| 6 | Fundic gland polyps and as- sociation with proton pump inhibitor intake: a prospective study in 1 780 endoscopies显示文摘 | Zeher A Fern6ndez JL Bilder C | 2011 | Dig Dis Sci2011，56，6： | 1 |
| 7 | Efficacy and safety of enteric-coatedmycophenolate sodium in combination with two glucocorticoid regi-mens for the treatment of active lupus nephritis显示文摘 | Zeher M Doria A Lan J | 2011 | Lupus2011，20，14： | 1 |
| 8 | Correlation of increased susceptibility to apoptosis of CD4+ T cells with lymphocyte activation and activity of disease in patients with primary Sjgren's syndrome显示文摘 | Zeher M Szodoray P Gyimesi E | 1999 | Arthritis Rheum1999，42，8： | 1 |
| 9 | Synthesen durch Michael - addition von pyridiniumsalzen 显示文摘 | KROEHNKE F ZEHER W CURTZE J | 1962 | Angew Chem1962，74，21： | 1 |
| 10 | Clinical, serologic, and genetic profiles of patients with associated SjOgrens syndrome and sys- temic lupus erythematosus显示文摘 | Szanto A Szodoray P Kiss E Kapitany A Szegedi G Zeher M | 2006 | Hum Immunol2006，67，： | 1 |
| 11 | Biomarkers in lupus nephritis显示文摘 | Brugos B Zeher M | 2010 | Orv Hetil2010，151，29： | 1 |
| 12 | Biomarkers in lupus nephritis显示文摘 | BRUGOS B ZEHER M | 2010 | Orv Hetil2010，151，29： | 1 |
| 13 | Clinical Course, Prognosis, and Cause of Death in Primary Sj?gren’s Syndrome显示文摘 | Ildiko Fanny Horvath Antonia Szanto Gabor Papp Margit Zeher Clelia M. Riera | 2014 | Journal of Immunology Research2014，，： | 1 |
| 14 | Correlation of increased susceptibility to apoptosis of CD4+T cells with lymphocyte activation and activity of disease in patients with primary Sjogren's syndrome显示文摘 | Zeher M Szodoray P Gyimesi E | 1999 | Arthritis Rheum1999，42，8： | 1 |
| 15 | Microtubule nucle- ating gamma-TuSC assembles structures with 13-fold mi- crotubule-like symmetry显示文摘 | Kollman JM Polka JK Zeher A | 2010 | Nature2010，466，7308： | 1 |
| 16 | Do qutoantibodies dredict autoimmune liver disease in primary Sjgren's syndrome Date of 180 patients upon a 5 year follow-up显示文摘 | CSEPREGI A SZODORAY P ZEHER M | 2002 | Scandinavian Journal of Immunology2002，56，6： | 1 |
| 17 | Do autoantibodies predict autoimmune liver disease in primary Sjogren's syndrome? Data of 180 patients upon a 5 year follow-up显示文摘 | Csepregi A Szodoray P Zeher M | 2002 | Scand J Immunol2002，56，6： | 1 |
| 18 | Biomarkers in lupus nephritis 显示文摘 | Brugos B Zeher M | 2010 | Orv Hetil2010，151，29： | 1 |
| 19 | Microcirculation of the fingers in Raynaud's syndrome:(99m)Tc-DTPA imaging显示文摘 | Csiki Z Garai I Varga J Szucs G Galajda Z Andras C Zeher M Galuska L | 2005 | Nuklearmedizin2005，44，1： | 1 |
| 20 | Biomarkers in lupus nephritis显示文摘 | Brugos B Zeher M | 2010 | Orv Hetil2010，151，29： | 1 |
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