|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes显示文摘Paeoniflorin (PF ) 是从 Paeonia lactiflora 的根提取的主要有效部件之一,它临床上被使用了在未知的内在的 mechanismremain 的繁体中文药,而是细节对待肝炎。现在的学习被设计在 d-galactosamine (GalN ) 和肿瘤坏死因素上调查 PF 的保护的效果的机制 --(TNF-) 用人的 L02 hepatocytes 导致了房间 apoptosis。我们 PF 能稀释的 resultsconfirmed GalN/TNF -- 以一种剂量依赖者方式的导致的 apoptotic 房间死亡。mitochondrialmembrane 潜力和细胞内部的 Ca 2+ 集中的骚乱的混乱被 PF 也恢复。西方的污点分析表明 GalN/TNF- 导致了一个 numberof 签名 endoplasmic 蜂窝胃的激活(嗯) 压力和 mitochondrial 标记,当 PF 预告的处理在他们上有显著 dose-dependentsuppression 时。另外, PF 的 anti-apoptotic 效果被 caspase-3/9activities 的抑制进一步在 L02 房间证实。这些调查结果建议那 PF 能有效地禁止与调整调停人有关的 hepatocyte apoptosis 和内在的 mechanismis 在嗯压力和线粒体依赖者小径。 | Zequn Jiang Funding This work was supported by grants from the National Natural Science Foundation of China (81072777 and 81273638) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).Weiping Chen Xiaojing Yan Lei Bi Sheng Guo Zhen Zhan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 5 |
| 2 | Study on the diversification of origins and primary development of Chinese porcelain glazes显示文摘With the support of the Origin Exploring of Chinese Civilization Projects (II) and National Natural Science Foundation of China,the close relationship among 'pottery coat','kiln sweat' and Chinese proto-porcelain glaze were studied,the characteristics and the key foundation of the origin of porcelain glaze were also discussed based on the relevant research results by Shanghai Institute of Ceramics,Chinese Academy of Sciences and Jingdezhen Ceramics Institute. | WU Juan ZHANG MaoLin WU JunMing LI QiJiang LI JiaZhi DENG ZeQun JIANG Xia | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 3 | Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinase up-regulation via cAMP signaling pathway显示文摘在这研究,我们证实了那芝麻明,从芝麻种子和油孤立的活跃 lignan,是新奇晒黑皮的混合物。黑素内容和 tyrosinase 活动被芝麻明在 B16 黑瘤房间以一种剂量依赖者方式增加。tyrosinase 的 mRNA 和蛋白质层次也与芝麻明在处理以后被提高。西方的污点分析揭示了导致并且支撑联系 microphthalmia 的抄写因素(MITF ) 的起来规定的那芝麻明。芝麻明能激活营地反应元素(CRE ) 有约束力的蛋白质(CREB ) ,但是它没在 p38 的 phosphorylation 上有效果激活 mitogen 的蛋白质 kinase (MAPK ) 或 Akt。而且,芝麻明经由一条营地依赖者小径激活蛋白质 kinase A (PKA ) 。与这些结果一致,黑素合成的调停芝麻明的增加被 H-89 显著地减少,一个 PKA 禁止者,然而并非由 SB203580,一个 p38 MAPK 禁止者或由 LY294002,一个 phosphatidylinositol-3-kinase (PI3K ) 禁止者。CREB 的调停芝麻明的 phosphorylation 和 MITF 和 tyrosinase 表示的正式就职被 H-89 也禁止。这些调查结果显示那芝麻明能经由 MITF 和 tyrosinase 的起来规定在 B16 房间刺激 melanogenesis,接着,它由于营地发信号的激活。 | Zequn Jiang Shasha Li Yunyi Liu Pengyi Deng Jianguo Huang Guangyuan He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 4 | 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis显示文摘Previous studies have shown that 5-hydroxymethylfurfural,a compound extracted from wineprocessed Fructus corni,has a protective effect on hippocampal neurons.The present study was designed to explore the related mechanisms.Our study revealed that high and medium doses(10,1μmol/L)of 5-hydroxymethylfurfural could improve the morphology of H2O2-treated rat hippocampal neurons as revealed by inverted phase-contrast microscopy and transmission electron microscopy.MTT results showed that incubation with high and medium doses of 5-hydroxymethylfurfural caused a significant increase in the viability of neuronal cells injured by H2O2.Flow cytometry assays confirmed that H2O2could induce cell apoptosis,while high and medium doses of5-hydroxymethylfurfural had a visible protective effect on apoptotic rat hippocampal neurons.Real-time PCR and western blot analysis showed that high and medium doses of5-hydroxymethylfurfural prevented H2O2-induced up-regulation of p53,Bax and caspase-3 and antagonized the down-regulation of Bcl-2 induced by H2O2treatment.These results suggested that5-hydroxymethylfurfural could inhibit apoptosis of cultured rat hippocampal neurons injured by H2O2via increase in Bcl-2 levels and decrease in p53,Bax and caspase-3 protein expression levels. | Hai Gu Zequn Jiang Mingyan Wang Haiying Jiang Fengming Zhao Xia Ding Baochang Cai Zhen Zhan | 2013 | Neural Regeneration Research2013，8，28： | 1 |
| 5 | 2,3,5,4,-tetxahydroxystilbene-2-O-p-d-glucoside ( THSG ) inducesraelanogenesis in B16 cells by MA Pkinase activation andtyrosinase upregulation 显示文摘 | Zequn Jiang Jimin Xu Minghai Long | 2009 | Life Sciences2009，85，9： | 1 |
| 6 | Picture-Induced EEG Signal Classification Based on CVC Emotion Recognition System显示文摘Emotion recognition systems are helpful in human-machine interactions and Intelligence Medical applications.Electroencephalogram(EEG)is closely related to the central nervous system activity of the brain.Compared with other signals,EEG is more closely associated with the emotional activity.It is essential to study emotion recognition based on EEG information.In the research of emotion recognition based on EEG,it is a common problem that the results of individual emotion classification vary greatly under the same scheme of emotion recognition,which affects the engineering application of emotion recognition.In order to improve the overall emotion recognition rate of the emotion classification system,we propose the CSP_VAR_CNN(CVC)emotion recognition system,which is based on the convolutional neural network(CNN)algorithm to classify emotions of EEG signals.Firstly,the emotion recognition system using common spatial patterns(CSP)to reduce the EEG data,then the standardized variance(VAR)is selected as the parameter to form the emotion feature vectors.Lastly,a 5-layer CNN model is built to classify the EEG signal.The classification results show that this emotion recognition system can better the overall emotion recognition rate:the variance has been reduced to 0.0067,which is a decrease of 64%compared to that of the CSP_VAR_SVM(CVS)system.On the other hand,the average accuracy reaches 69.84%,which is 0.79%higher than that of the CVS system.It shows that the overall emotion recognition rate of the proposed emotion recognition system is more stable,and its emotion recognition rate is higher. | Huiping Jiang Zequn Wang Rui Jiao Shan Jiang | 2020 | Computers, Materials & Continua2020，，11： | 0 |
| 7 | Systematic analysis on expression quantitative trait loci identifies a novel regulatory variant in ring finger and WD repeat domain 3 associated with prognosis of pancreatic cancer显示文摘Background:Pancreatic adenocarcinoma(PAAD)is an extremely lethal malignancy.Identification of the functional genes and genetic variants related to PAAD prognosis is important and challenging.Previously identified prognostic genes from several expression profile analyses were inconsistent.The regulatory genetic variants that affect PAAD prognosis were largely unknown.Methods:Firstly,a meta-analysis was performed with seven published datasets to systematically explore the candidate prognostic genes for PAAD.Next,to identify the regulatory variants for those candidate genes,expression quantitative trait loci analysis was implemented with PAAD data resources from The Cancer Genome Atlas.Then,a two-stage association study in a total of 893 PAAD patients was conducted to interrogate the regulatory variants and find the prognostic locus.Finally,a series of biochemical experiments and phenotype assays were carried out to demonstrate the biological function of variation and genes in PAAD progression process.Results:A total of 128 genes were identified associated with the PAAD prognosis in the meta-analysis.Fourteen regulatory loci in 12 of the 128 genes were discovered,among which,only rs4887783,the functional variant in the promoter of Ring Finger and WD Repeat Domain 3(RFWD3),presented significant association with PAAD prognosis in both stages of the population study.Dualluciferase reporter and electrophoretic mobility shift assays demonstrated that rs4887783-G allele,which predicts the worse prognosis,enhanced the binding of transcript factor REST,thus elevating RFWD3 expression.Further phenotypic assays revealed that excess expression of RFWD3 promoted tumor cell migration without affecting their proliferation rate.RFWD3 was highly expressed in PAAD and might orchestrate the genes in the DNA repair process.Conclusions:RFWD3 and its regulatory variant are novel genetic factors for PAAD prognosis. | Ying Zhu Xiating Peng Xiaoyang Wang Pingting Ying Haoxue Wang Bin Li Yue Li Ming Zhang Yimin Cai Zequn Lu Siyuan Niu Nan Yang Rong Zhong Jianbo Tian Jiang Chang Xiaoping Miao | 2022 | Chinese Medical Journal2022，，11： | 0 |
| 8 | Emotion Recognition Using WT-SVM in Human-Computer Interaction显示文摘With the continuous development of the computer, people's requirements for computers are also getting more and more, so the brain-computer interface system (BCI) has become an essential part of computer research. Emotion recognition is an important task for the computer to understand social status in BCI. Affective computing (AC) aims to develop the model of emotions and advance the affective intelligence of computers. There are various emotion recognition approaches. The method based on electroencephalogram (EEG) is more reliable because it is higher in accuracy and more objective in evaluation than other external appearance clues such as emotion expression and gesture. In this paper, we use the wavelet transform (WT) to extract three kinds of EEG features in time, and frequency domain, which are sub-band energy, energy ratio and root mean square of wavelet coefficients. They reflect the emotion related to EEG activities well. The average classification accuracy of support vector machine (SVM) can reach 82.87%, which indicates that these three features are very effective in emotion recognition. On the other hand, compared with international affective picture system (IAPs), EEG data collected by Chinese affective picture system (CAPs) stimulation has a higher emotion recognition rate, indicating that there are cultural background differences in emotions. | Zequn Wang Rui Jiao Huiping Jiang | 2020 | Journal of New Media2020，2，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员