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| 1 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 2 | Metabonomic phenotype and identification of “heart blood stasis obstruction pattern” and “qi and yin deficiency pattern” of myocardial ischemia rat models显示文摘The traditional Chinese medicine concepts of 'Xinxueyuzuzheng (heart blood stasis obstruction pattern)' and 'Qiyinliangxuzheng (qi and yin deficiency pattern)' for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two 'pattern' rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two 'patterns' are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two 'Zhengxing (pattern types)' of myocardial ischemia, and 'Bianzheng (pattern identification)'. | YAN Bei1, A JiYe1, HAO HaiPing1, WANG GuangJi1, ZHU XuanXuan2, 3, ZHA WeiBin1, LIU LinSheng1, GUAN EnZe3, ZHANG Ying1, GU ShengHua1, HUANG Qing1 & ZHENG YuanTing1 1Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China 2Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China 3College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China | 2009 | Science China(Life Sciences)2009，52，11： | 19 |
| 3 | Developmental Genetics Analysis for Plant Height in indica Hybrid Rice Across Environments显示文摘The developmental genetics of plant height was analyzed from two groups of three-line indica hybrid rice at two environmental conditions based on the NCII design,using the additive-dominant developmental genetics models and the statistic methods.The results showed that the rice genotypes and environmental conditions could both affect plant height,and the effects of environment on plant height decreased gradually with plant development.Additive and dominant effects both governed the performance of plant height at all developmental stages.However,the degrees of effect varied among the rice genotypes.Moreover,the interaction between environments and genotypes also affected plant height.The genetic effects differed at most developmental stages.Furthermore,the expression of additive effect was more active than that of dominant effect.Conditional interaction effects with environment also influenced plant height during genetic development,especially at the early stage.Mid-parent heterosis(HMP) increased gradually with the developmental stage of plant height,and maximized at the latest stage,whereas the heterosis over the better parent(HBP) showed small differences among the genotypes,and kept stable at the later stage,with positive numeric value.At most developmental stages,conditional HMP was positively significant,while conditional HBP was negatively significant.All above results suggest that HMP and HBP have some new expressions in all developmental periods and the levels and directions are quite different. | PENG Tao ZHONG Bing-qiang LING Ying-hua YANG Zheng-lin ZHA Ren-ming XIE Rong LIU Cheng-yuan HE Guang-hua | 2009 | Rice science2009，16，2： | 14 |
| 4 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 5 | Relationship between electrochemical characteristics and SCC of X70 pipeline steel in an acidic soil simulated solution显示文摘Stress corrosion cracking (SCC) of X70 pipeline steel in simulated solution of the acidic soil in Yingtan in China was investigated using slow strain rate test (SSRT), SEM and potentiodynamic polarization technique. Experiment results indicate that X70 steel is highly susceptible to SCC as applied potential reduces, which is manifested in loss of toughness and brittle fracture. Constant polarization current can detect the occurrence of SCC. The lower the polarization current is the sooner stress corrosion cracking occurs. The SCC mechanisms are different at varying potentials. When potential is higher than open circuit potential, anodic process controls SCC, whereas when potential is far lower than open circuit potential, cathodic process controls SCC, and between these two potential regions, a combined electrochemical process controls the SCC. Stress or strain has a synergistic effect with electrochemical reactions to accelerate the cathodic hydrogen evolution process, which makes the X70 pipeline steel to be more susceptible to SCC. | Zhiyong LIU Xiaogang LI Yingrui ZHANG Cuiwei DU Guoli ZHA | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 13 |
| 6 | A review on China's constructed wetlands in recent three decades:Application and practice显示文摘Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors.Firstly,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric analysis.Secondly,the most principal components of CWs,substrates and macrophytes were summarized and analyzed.Thirdly,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were presented.In China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic conditions.It is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern development.There has been a trend of large-scale or low-cost CW application in the recent years.However,lifecycle research and management are required for better strategies in the future. | Hong Zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian Zhang Cao Liu Jinmiao Zha | 2021 | Journal of Environmental Sciences2021，33，6： | 13 |
| 7 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 8 | Radial profile of sap flow velocity in mature Xinjiang poplar(Populus alba L. var. pyramidalis) in Northwest China显示文摘Estimation of the transpiration rate for a tree is generally based on sap flow measurements within the hydro-active stem xylem. In this study, radial variation of sap flow velocity(Js) was investigated at five depths of the xylem(1, 2, 3, 5 and 8 cm under the cambium) in three mature Xinjiang poplar(Populus alba L. var. pyramidalis) trees grown at the Gansu Minqin National Studies Station for Desert Steppe Ecosystem from May to October 2011. Thermal dissipation probes of various lengths manufactured according to the Granier's design were installed into each tree for simultaneous observation of the radial patterns of Js through the xylem. The radial patterns were found to fit the four-parameter GaussAmp equation. The peak Js was about 27.02±0.95 kg/(dm2?d) at approximately 3 to 5 cm deep from the cambium of the three trees,and the lowest Js appeared at 1 cm deep in most of the time. Approximately 50% of the total sap flow in Xinjiang poplar occurred within one-third of the xylem from its outer radius, whereas 90% of the total sap flow occurred within two-fifth of the xylem. In addition, the innermost point of the xylem(at 8-cm depth), which appeared as the penultimate sap flow in most cases during the study period, was hydro-active with Js,8 of 7.55±3.83 kg/(dm2?d). The radial pattern of Js was found to be steeper in midday than in other time of the day, and steeper diurnal fluctuations were recorded in June, July and August(the mid-growing season). Maximum differences between the lowest Js(Js,1 or Js,8) and the highest Js(Js,3 or Js,5) from May through October were 12.41, 17.35, 16.30, 18.52, 12.60 and 16.04 g/(cm2?h), respectively. The time-dependent changes of Js along the radial profile(except at 1-cm depth) were strongly related to the reference evapotranspiration(ET0). Due to significant radial variability of Js, the mean daily sap flow at the whole-tree level could be over-estimated by up to 29.69% when only a single probe at depth of 2 cm was used. However, the accuracy of the estimation of sap flow in Xinjiang poplar could be significantly improved using a correction coefficient of 0.885. | HongZhong DANG TianShan ZHA JinSong ZHANG Wei LI ShiZeng LIU | 2014 | Journal of Arid Land2014，6，5： | 11 |
| 9 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 10 | Effects of Heat Treatment and Nitrogen on Microstructure and Mechanical Properties of 1Cr12NiMo Martensitic Stainless Steel显示文摘A series of heat treatments using the orthogonal experiment method were performed to study the microstructure and mechanical properties of 1Cr12NiMo martensitic stainless steel containing various nitrogen content addition. The results indicate that the optimal heat treatment is annealing at 830℃ for 1 h, austenitizing at 985℃ for 1 h followed by oil quenching, and tempering at 630℃ for 4 h followed by air cooling. Nitrogen addition to 1Cr12NiMo steel can effectively hinder the austenite grain growth, refine the martensite lath, and increase the strength and hardness. The impact toughness of this steel only shows a minor decrease as the nitrogen content increases. | Ruicheng Fan Ming Gao Yingche Ma Xiangdong Zha Xianchao Hao Kui Liu | 2012 | Journal of Materials Science & Technology2012，28，11： | 10 |
| 11 | Self-assembled core-shell polydopamine@MXene with synergistic solar absorption capability for highly efficient solar-to-vapor generation显示文摘As a renewable and environment-friendly technology for seawater desalination and wastewater purification,solar energy triggered steam generation is attractive to address the long-standing global water scarcity issues.However,practical utilization of solar energy for steam generation is severely restricted by the complex synthesis,low energy conversion efficiency,insufficient solar spectrum absorption and water extraction capability of state-of-the-art technologies.Here,for the first time,we report a facile strategy to realize hydrogen bond induced self-assembly of a polydopamine(PDA)@MXene microsphere photothermal layer for synergistically achieving wide-spectrum and highly efficient solar absorption capability(≈96%in a wide solar spectrum range of 250–1,500 nm wavelength).Moreover,such a system renders fast water transport and vapor escaping due to the intrinsically hydrophilic nature of both MXene and PDA,as well as the interspacing between core-shell microspheres.The solar-to-vapor conversion efficiencies under the solar illumination of 1 sun and 4 sun are as high as 85.2%and 93.6%,respectively.Besides,the PDA@MXene photothermal layer renders the system durable mechanical properties,allowing producing clean water from seawater with the salt rejection rate beyond 99%.Furthermore,stable light absorption performance can be achieved and well maintained due to the formation of ternary TiO2/C/MXene complex caused by oxidative degradation of MXene.Therefore,this work proposes an attractive MXene-assisted strategy for fabricating high performance photothermal composites for advanced solar-driven seawater desalination applications. | Xing Zhao Xiang-Jun Zha Li-Sheng Tang Jun-Hong Pu Kai Ke Rui-Ying Bao Zheng-ying Liu Ming-Bo Yang Wei Yang | 2020 | Nano Research2020，13，1： | 10 |
| 12 | Sedimentary fill history of the Huicheng Basin in the West Qinling Mountains and associated constraints on Mesozoic intracontinental tectonic evolution显示文摘The Qinling Orogenic Belt is divided commonly by the Fengxian-Taibai strike-slip shear zone and the Huicheng Basin into the East and West Qinling mountains,which show significant geological differences after the Indosinian orogeny.The Fengxian-Taibai fault zone and the Meso-Cenozoic Huicheng Basin,situated at the boundary of the East and West Qinling,provide a natural laboratory for tectonic analysis and sedimentological study of intracontinental tectonic evolution of the Qinling Orogenic Belt.In order to explain the dynamic development of the Huicheng Basin and elucidate its post-orogenic tectonic evolution at the junction of the East and West Qinling,we studied the geometry and kinematics of fault zones between the blocks of West Qinling,as well as the sedimentary fill history of the Huicheng Basin.First,we found that after the collisional orogeny in the Late Triassic,post-orogenic extensional collapse occurred in the Early and Middle Jurassic within the Qinling Orogenic Belt,resulting in a series of rift basins.Second,in the Late Jurassic and Early Cretaceous,a NE-SW compressive stress field caused large-scale sinistral strike-slip faults in the Qinling Orogenic Belt,causing intracontinental escape tectonics at the junction of the East and West Qinling,including eastward finite escape of the East Qinling micro-plate and southwest lateral escape of the Bikou Terrane.Meanwhile,the strike-slip-related Early Cretaceous sedimentary basin was formed with a right-order echelon arrangement in sinistral shear zones along the southern margin of the Huicheng fault.Overall during the Mesozoic,the Huicheng Basin and surrounding areas experienced four tectonic evolutionary stages,including extensional rift basin development in the Early and Middle Jurassic,intense compressive uplift in the Late Jurassic,formation of a strike-slip extensional basin in the Early Cretaceous,and compressive uplift in the Late Cretaceous. | LI Wei DONG YunPeng GUO AnLin LIU XiaoMing LIU YiQun ZHA XianFeng ZHANG KuaiLe | 2013 | Science China Earth Sciences2013，56，10： | 7 |
| 13 | Novel Recombinant Seneca Valley Virus Isolated from Slaughtered Pigs in Guangdong Province显示文摘Dear Editor,Since the first outbreak in Brazil in 2015,Seneca Valley virus(SVV)associated with porcine idiopathic vesicular disease,has shown increasing geographic distribution.Cases of SVV have been reported from several countries including the United States(US),Colombia,Thailand,Canada,and China(Pasma et al.2008;Zhang et al.2015;Sun et al.2017;Wu et al.2017;Liu et al.2018;Saeng-Chuto et al.2018).SVV was first identified in the US in 2002 and is the only member of the genus Senecavirus in the family Picomaviridae(Hales et al.2008;Leme et al.2017).The SVV genome contains a large open reading frame(ORF)encoding a polyprotein,which is cleaved into various mature viral proteins including the leader protein(L),structural proteins(VP1,VP2,VP3,and VP4),and non-structural proteins(2A,2B,2C,3A,3B,3C,and 3D)(Hales et al 2008).Structural proteins bind to their receptor,anthrax toxin receptor 1,to mediate viral invasion and stimulate specific immunity of the host(Jayawardena et al.2018).Non-structural proteins such as 3C suppress innate immune responses by degrading interferon regulatory factor 3(IRF 3)and IRF7 and inhibit the activation of RIG-1,TBK1,and TRAF3 through deubiquitination(Xue et al 2018). | Jianxin Liu Yunfeng Zha Huizi Li Yanwei Sun Fuguang Wang Rong Lu Zhangyong Ning | 2019 | Virologica Sinica2019，34，6： | 7 |
| 14 | Cathepsin B protease is required for metamorphism in silkworm, Bombyx moil显示文摘 | Gen-Hong Wang Chun Liu Qing-You Xia Xing-Fu Zha Jie Chen Liang Jiang | 2008 | Insect Science2008，15，3： | 6 |
| 15 | Mitochondrial aldehyde dehydrogenase(ALDH2)rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis显示文摘Alzheimer’s disease(AD)is associated with high incidence of cardiovascular events but the mechanism remains elusive.Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase(ALDH2)activity in elderly AD patients.In the present study we investigated the effect of ALDH2 overexpression on cardiac function in APP/PS1 mouse model of AD.Global ALDH2 transgenic mice were crossed with APP/PS1 mutant mice to generate the ALDH2-APP/PS1 mutant mice.Cognitive function,cardiac contractile,and morphological properties were assessed.We showed that APP/PS1 mice displayed significant cognitive deficit in Morris water maze test,myocardial ultrastructural,geometric(cardiac atrophy,interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies along with oxidative stress,apoptosis,and inflammation in myocardium.ALDH2 transgene significantly attenuated or mitigated these anomalies.We also noted the markedly elevated levels of lipid peroxidation,the essential lipid peroxidation enzyme acyl-CoA synthetase long-chain family member 4(ACSL4),the transcriptional regulator for ACLS4 special protein 1(SP1)and ferroptosis,evidenced by elevated NCOA4,decreased GPx4,and SLC7A11 in myocardium of APP/PS1 mutant mice;these effects were nullified by ALDH2 transgene.In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro,application of Aβ(20μM)decreased cell survival,compromised cardiomyocyte contractile function,and induced lipid peroxidation;ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects.ALDH2-induced protection against Aβ-induced lipid peroxidation was mimicked by the SP1 inhibitor tolfenamic acid(TA)or the ACSL4 inhibitor triacsin C(TC),and mitigated by the lipid peroxidation inducer 5-hydroxyeicosatetraenoic acid(5-HETE)or the ferroptosis inducer erastin.These results demonstrate an essential role for ALDH2 in AD-induced cardiac anomalies through regulation of lipid peroxidation and ferroptosis. | Zhi-yun Zhu Yan-dong Liu Yan Gong Wei Jin Elena Topchiy Subat Turdi Yue-feng Gao Bruce Culver Shu-yi Wang Wei Ge Wen-liang Zha Jun Ren Zhao-hui Pei Xing Qin | 2022 | Acta Pharmacologica Sinica2022，43，1： | 6 |
| 16 | Thrombin-like enzymes from venom gland of Deinagkistrodon acutus:cDNA cloning,mechanism of diversity and phylogenetic tree construc-tion显示文摘瞄准:从 Deinagkistrodon acutus 的毒液腺克隆像凝血酵素的酶(TLE ) 的 cDNAs 并且分析他们的结构的差异由产生了的机制。方法:克隆技术的反向的抄写聚合酶链反应和基因被使用,并且克隆的序列被使用生物信息学工具分析。结果:蛇毒 TLE 的新奇 cDNAs 被克隆。post-transcriptional 再结合和水平基因转移的可能性被讨论。一棵种系发生的树被构造。结论:蛇毒 TLE 的 cDNAs 展出大多样化。有结构的变化的几种类型。这些变化可能对包括再结合的某些机制可归因。 | Xiang-dong ZHA He-sheng HUANG Li-zhi ZHOU Jing LIU Kang-sen XU | 2006 | Acta Pharmacologica Sinica2006，27，2： | 6 |
| 17 | Surrounding rock control of gob-side entry driving with narrow coal pillar and roadway side sealing technology in Yangliu Coal Mine显示文摘Gob-side entry driving can increase coal recovery ratio, and it is implied in many coal mines. Based on geological condition of 10416 working face tailentry in Yangliu Coal Mine, the surrounding rock deformation characteristics of gob-side entry driving with narrow coal pillar is analysed, reasonable size of coal pillar and reasonable roadway excavation time after mining are achieved. Surrounding rock control technology and effective roadway side sealing technology are proposed and are taken into field practice. The results showed that a safer and more efficient mining of working face can be achieved. In addition, results of this paper also have important theoretical significance and valuable reference for surrounding rock control technology of gob-side entry driving with narrow coal pillar under special geological condition. | Zha Wenhua Shi Hao Liu San Kang Changhao | 2017 | International Journal of Mining Science and Technology2017，27，5： | 6 |
| 18 | Subsidence control and farmland conservation by solid backfilling mining technology显示文摘Solid backfilling mining technology, which decreases the height of fissure zone and caving zone, and alleviates the subsidence, is a new technology for farmland conservation. Based on the situation analysis of farmland destruction in mining area, three ways for farmland protection were proposed. In order to improve the feasibility of this technology, the limited filling materials should be used to increase resources recovery ratio, and then the surplus materials could be backfilled into goaf. An index, namely farmland conservation ability, was put forward to optimize the ways for farmland conservation. At last, the Wanbei coal mine was taken as a case for farmland conservation. It was shown that 3240 t dull coal was substituted and 52 hm2 farmland was conserved by solid backfilling mining in this coal mine. | GUO Guang-li1, 2, FENG Wen-kai3, ZHA Jian-feng1, 2, 3, LIU Yuan-xu1, 2, WANG Qiang1, 2 1. Key Laboratory for Land Environment and Disaster Monitoring of the State Bureau of Surveying and Mapping, China University of Mining and Technology, Xuzhou 221116, China 2. Jiangsu Key Laboratory of Resources and Environmental Information Engineering, China University of Mining and Technology, Xuzhou 221116, China 3. State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu 610059, China | 2011 | 中国有色金属学会会刊:英文版2011，21，S3： | 6 |
| 19 | Stability Analysis of PLL Influenced by Control Loops in Grid-connected Converters Under Fault Disturbance显示文摘When the power grid suffers from grid faults that cause phase disturbances,the grid-connected converter becomes destabilized by the interaction between the phase-locked loop(PLL)and the control loop.In this paper,the stability of the PLL affected by the control loop under transient grid faults is studied.First,the equivalent model of the PLL under the influence of the control loop is established.Then,different response processes of PLLs under the ground fault with various control parameters are qualitatively analyzed.Furthermore,a small-signal model is proposed to assess the stability of the PLL under different control loop parameters.The system poles can be calculated to show the physical origin of the instability.Finally,simulations of a three-phase 21-level modular multilevel converter(MMC)built in PSCAD and a down-scale experiment is performed to verify the parameter influence of the control loop on the PLL. | Yushuang Liu Meng Huang Xiaoming Zha Herbert Ho-Ching Iu | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 6 |
| 20 | Identification of maca(Lepidium meyenii Walp.) and its adulterants by a DNA-barcoding approach based on the ITS sequence显示文摘Maca(Lepidium meyenii) is an herbaceous plant that grows in high plateaus and has been used as both food and folk medicine for centuries because of its benefits to human health. In the present study, ITS(internal transcribed spacer) sequences of forty-three maca samples, collected from different regions or vendors, were amplified and analyzed. The ITS sequences of nineteen potential adulterants of maca were also collected and analyzed. The results indicated that the ITS sequence of maca was consistent in all samples and unique when compared with its adulterants. Therefore, this DNA-barcoding approach based on the ITS sequence can be used for the molecular identification of maca and its adulterants. | CHEN Jin-Jin ZHAO Qing-Sheng LIU Yi-Lan ZHA Sheng-Hua ZHAO Bing | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 6 |
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